The N‐Acetylgalactosamine‐conjugated small interfering RNA inclisiran can be coadministered safely with atorvastatin in cynomolgus monkeys resulting in additive low‐density lipoprotein cholesterol reductions

The N‐Acetylgalactosamine‐conjugated small interfering RNA inclisiran can be coadministered safely with atorvastatin in cynomolgus monkeys resulting in additive low‐density lipoprotein cholesterol reductions

Abstract Inclisiran, a small interfering RNA, selectively inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) synthesis in the liver and has been shown to reduce low‐density lipoprotein cholesterol (LDL‐C) by ≥50% in patients with hypercholesterolemia receiving maximally tolerated statins...

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Bibliographic Details
Main Authors: Dario Lehoux, David Kallend, Peter L. J. Wijngaard, Alan P. Brown, Brad Zerler
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Pharmacology Research & Perspectives
Subjects:
hydroxymethylglutaryl‐coenzyme a reductase inhibitors
hypercholesterolemia
LDL cholesterol
PCSK9 inhibitors
Online Access:https://doi.org/10.1002/prp2.1080

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