Analysis of mobility level of COVID-19 patients undergoing mechanical ventilation support: A single center, retrospective cohort study
<h4>Background</h4> Severe coronavirus disease 2019 (COVID-19) patients frequently require mechanical ventilation (MV) and undergo prolonged periods of bed rest with restriction of activities during the intensive care unit (ICU) stay. Our aim was to address the degree of mobilization in...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342786/?tool=EBI |
| _version_ | 1811221425189552128 |
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| author | Ricardo Kenji Nawa Ary Serpa Neto Ana Carolina Lazarin Ana Kelen da Silva Camila Nascimento Thais Dias Midega Raquel Afonso Caserta Eid Thiago Domingos Corrêa Karina Tavares Timenetsky |
| author_facet | Ricardo Kenji Nawa Ary Serpa Neto Ana Carolina Lazarin Ana Kelen da Silva Camila Nascimento Thais Dias Midega Raquel Afonso Caserta Eid Thiago Domingos Corrêa Karina Tavares Timenetsky |
| author_sort | Ricardo Kenji Nawa |
| collection | DOAJ |
| description | <h4>Background</h4> Severe coronavirus disease 2019 (COVID-19) patients frequently require mechanical ventilation (MV) and undergo prolonged periods of bed rest with restriction of activities during the intensive care unit (ICU) stay. Our aim was to address the degree of mobilization in critically ill patients with COVID-19 undergoing to MV support. <h4>Methods</h4> Retrospective single-center cohort study. We analyzed patients’ mobility level, through the Perme ICU Mobility Score (Perme Score) of COVID-19 patients admitted to the ICU. The Perme Mobility Index (PMI) was calculated [PMI = ΔPerme Score (ICU discharge–ICU admission)/ICU length of stay], and patients were categorized as “improved” (PMI > 0) or “not improved” (PMI ≤ 0). Comparisons were performed with stratification according to the use of MV support. <h4>Results</h4> From February 2020, to February 2021, 1,297 patients with COVID-19 were admitted to the ICU and assessed for eligibility. Out of those, 949 patients were included in the study [524 (55.2%) were classified as “improved” and 425 (44.8%) as “not improved”], and 396 (41.7%) received MV during ICU stay. The overall rate of patients out of bed and able to walk ≥ 30 meters at ICU discharge were, respectively, 526 (63.3%) and 170 (20.5%). After adjusting for confounders, independent predictors of improvement of mobility level were frailty (OR: 0.52; 95% CI: 0.29–0.94; p = 0.03); SAPS III Score (OR: 0.75; 95% CI: 0.57–0.99; p = 0.04); SOFA Score (OR: 0.58; 95% CI: 0.43–0.78; p < 0.001); use of MV after the first hour of ICU admission (OR: 0.41; 95% CI: 0.17–0.99; p = 0.04); tracheostomy (OR: 0.54; 95% CI: 0.30–0.95; p = 0.03); use of extracorporeal membrane oxygenation (OR: 0.21; 95% CI: 0.05–0.8; p = 0.03); neuromuscular blockade (OR: 0.53; 95% CI: 0.3–0.95; p = 0.03); a higher Perme Score at admission (OR: 0.35; 95% CI: 0.28–0.43; p < 0.001); palliative care (OR: 0.05; 95% CI: 0.01–0.16; p < 0.001); and a longer ICU stay (OR: 0.79; 95% CI: 0.61–0.97; p = 0.04) were associated with a lower chance of mobility improvement, while non-invasive ventilation within the first hour of ICU admission and after the first hour of ICU admission (OR: 2.45; 95% CI: 1.59–3.81; p < 0.001) and (OR: 2.25; 95% CI: 1.56–3.26; p < 0.001), respectively; and vasopressor use (OR: 2.39; 95% CI: 1.07–5.5; p = 0.03) were associated with a higher chance of mobility improvement. <h4>Conclusion</h4> The use of MV reduced mobility status in less than half of critically ill COVID-19 patients. |
| first_indexed | 2024-04-12T07:59:06Z |
| format | Article |
| id | doaj.art-b10d3a94463a4d0b98d04325629b1761 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T07:59:06Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b10d3a94463a4d0b98d04325629b17612022-12-22T03:41:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01178Analysis of mobility level of COVID-19 patients undergoing mechanical ventilation support: A single center, retrospective cohort studyRicardo Kenji NawaAry Serpa NetoAna Carolina LazarinAna Kelen da SilvaCamila NascimentoThais Dias MidegaRaquel Afonso Caserta EidThiago Domingos CorrêaKarina Tavares Timenetsky<h4>Background</h4> Severe coronavirus disease 2019 (COVID-19) patients frequently require mechanical ventilation (MV) and undergo prolonged periods of bed rest with restriction of activities during the intensive care unit (ICU) stay. Our aim was to address the degree of mobilization in critically ill patients with COVID-19 undergoing to MV support. <h4>Methods</h4> Retrospective single-center cohort study. We analyzed patients’ mobility level, through the Perme ICU Mobility Score (Perme Score) of COVID-19 patients admitted to the ICU. The Perme Mobility Index (PMI) was calculated [PMI = ΔPerme Score (ICU discharge–ICU admission)/ICU length of stay], and patients were categorized as “improved” (PMI > 0) or “not improved” (PMI ≤ 0). Comparisons were performed with stratification according to the use of MV support. <h4>Results</h4> From February 2020, to February 2021, 1,297 patients with COVID-19 were admitted to the ICU and assessed for eligibility. Out of those, 949 patients were included in the study [524 (55.2%) were classified as “improved” and 425 (44.8%) as “not improved”], and 396 (41.7%) received MV during ICU stay. The overall rate of patients out of bed and able to walk ≥ 30 meters at ICU discharge were, respectively, 526 (63.3%) and 170 (20.5%). After adjusting for confounders, independent predictors of improvement of mobility level were frailty (OR: 0.52; 95% CI: 0.29–0.94; p = 0.03); SAPS III Score (OR: 0.75; 95% CI: 0.57–0.99; p = 0.04); SOFA Score (OR: 0.58; 95% CI: 0.43–0.78; p < 0.001); use of MV after the first hour of ICU admission (OR: 0.41; 95% CI: 0.17–0.99; p = 0.04); tracheostomy (OR: 0.54; 95% CI: 0.30–0.95; p = 0.03); use of extracorporeal membrane oxygenation (OR: 0.21; 95% CI: 0.05–0.8; p = 0.03); neuromuscular blockade (OR: 0.53; 95% CI: 0.3–0.95; p = 0.03); a higher Perme Score at admission (OR: 0.35; 95% CI: 0.28–0.43; p < 0.001); palliative care (OR: 0.05; 95% CI: 0.01–0.16; p < 0.001); and a longer ICU stay (OR: 0.79; 95% CI: 0.61–0.97; p = 0.04) were associated with a lower chance of mobility improvement, while non-invasive ventilation within the first hour of ICU admission and after the first hour of ICU admission (OR: 2.45; 95% CI: 1.59–3.81; p < 0.001) and (OR: 2.25; 95% CI: 1.56–3.26; p < 0.001), respectively; and vasopressor use (OR: 2.39; 95% CI: 1.07–5.5; p = 0.03) were associated with a higher chance of mobility improvement. <h4>Conclusion</h4> The use of MV reduced mobility status in less than half of critically ill COVID-19 patients.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342786/?tool=EBI |
| spellingShingle | Ricardo Kenji Nawa Ary Serpa Neto Ana Carolina Lazarin Ana Kelen da Silva Camila Nascimento Thais Dias Midega Raquel Afonso Caserta Eid Thiago Domingos Corrêa Karina Tavares Timenetsky Analysis of mobility level of COVID-19 patients undergoing mechanical ventilation support: A single center, retrospective cohort study PLoS ONE |
| title | Analysis of mobility level of COVID-19 patients undergoing mechanical ventilation support: A single center, retrospective cohort study |
| title_full | Analysis of mobility level of COVID-19 patients undergoing mechanical ventilation support: A single center, retrospective cohort study |
| title_fullStr | Analysis of mobility level of COVID-19 patients undergoing mechanical ventilation support: A single center, retrospective cohort study |
| title_full_unstemmed | Analysis of mobility level of COVID-19 patients undergoing mechanical ventilation support: A single center, retrospective cohort study |
| title_short | Analysis of mobility level of COVID-19 patients undergoing mechanical ventilation support: A single center, retrospective cohort study |
| title_sort | analysis of mobility level of covid 19 patients undergoing mechanical ventilation support a single center retrospective cohort study |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342786/?tool=EBI |
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