Recent progress and perspectives on the relationship between hyperuricemia and periodontitis
Periodontitis is one of the most prevalent diseases in oral cavity, which could not merely lead to the destruction of supporting or surrounding tooth structures but also affect the whole-body health such as the digestive and nervous systems. Epidemiological investigations suggested that in some deve...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.995582/full |
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| author | Wenxue Hou Wenxue Hou Wenxue Hou Wenxue Hou Xiaomin Xia Xiaomin Xia Xiaomin Xia Xiaomin Xia Ying Li Ying Li Ying Li Ying Li Hanlin Lv Hanlin Lv Hanlin Lv Hanlin Lv Jie Liu Jie Liu Jie Liu Jie Liu Xue Li Xue Li Xue Li Xue Li |
| author_facet | Wenxue Hou Wenxue Hou Wenxue Hou Wenxue Hou Xiaomin Xia Xiaomin Xia Xiaomin Xia Xiaomin Xia Ying Li Ying Li Ying Li Ying Li Hanlin Lv Hanlin Lv Hanlin Lv Hanlin Lv Jie Liu Jie Liu Jie Liu Jie Liu Xue Li Xue Li Xue Li Xue Li |
| author_sort | Wenxue Hou |
| collection | DOAJ |
| description | Periodontitis is one of the most prevalent diseases in oral cavity, which could not merely lead to the destruction of supporting or surrounding tooth structures but also affect the whole-body health such as the digestive and nervous systems. Epidemiological investigations suggested that in some developed countries, more than 45% or even 50% population were suffering from periodontitis. However, the prevalence increases with age remarkably and it is investigated that a high prevalence (>50%) is affecting the elderly who is over 65 years old. There is an increasing interest in the direct and indirect relationships between periodontitis and hyperuricemia. Currently, hyperuricemia has become the second major metabolic disease in modern society and the prevalence of hyperuricemia among adult males and females was 21.7% and 14.4% respectively. As an inflammatory disease associated with various systemic diseases, periodontitis may have certain connections with hyperuricemia. Partial existing research announced that hyperuricemia could act as an inhibitory factor for periodontitis, while other scholars presented that a high uric acid (UA) level was more likely to aggravate inflammatory immune response and lead to more serious tissue destruction. This article provides a detailed and comprehensive overview of the relationship underlying hyperuricemia and periodontitis in the molecular mechanisms. Given the impact of hyperuricemia, this review could provide insight into its comorbidities. |
| first_indexed | 2024-04-13T10:46:01Z |
| format | Article |
| id | doaj.art-b10d3fdc875346c3a1f421ec7de6cc70 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T10:46:01Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b10d3fdc875346c3a1f421ec7de6cc702022-12-22T02:49:48ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.995582995582Recent progress and perspectives on the relationship between hyperuricemia and periodontitisWenxue Hou0Wenxue Hou1Wenxue Hou2Wenxue Hou3Xiaomin Xia4Xiaomin Xia5Xiaomin Xia6Xiaomin Xia7Ying Li8Ying Li9Ying Li10Ying Li11Hanlin Lv12Hanlin Lv13Hanlin Lv14Hanlin Lv15Jie Liu16Jie Liu17Jie Liu18Jie Liu19Xue Li20Xue Li21Xue Li22Xue Li23Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaDental Digital Medicine & 3D Printing Engineering Laboratory of Qingdao, Qingdao, ChinaDental Biomaterials Technology Innovation Center of Qingdao, Qingdao, ChinaDepartment of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaDental Digital Medicine & 3D Printing Engineering Laboratory of Qingdao, Qingdao, ChinaDental Biomaterials Technology Innovation Center of Qingdao, Qingdao, ChinaDepartment of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaDental Digital Medicine & 3D Printing Engineering Laboratory of Qingdao, Qingdao, ChinaDental Biomaterials Technology Innovation Center of Qingdao, Qingdao, ChinaDepartment of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaDental Digital Medicine & 3D Printing Engineering Laboratory of Qingdao, Qingdao, ChinaDental Biomaterials Technology Innovation Center of Qingdao, Qingdao, ChinaDepartment of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaDental Digital Medicine & 3D Printing Engineering Laboratory of Qingdao, Qingdao, ChinaDental Biomaterials Technology Innovation Center of Qingdao, Qingdao, ChinaDepartment of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaDental Digital Medicine & 3D Printing Engineering Laboratory of Qingdao, Qingdao, ChinaDental Biomaterials Technology Innovation Center of Qingdao, Qingdao, ChinaPeriodontitis is one of the most prevalent diseases in oral cavity, which could not merely lead to the destruction of supporting or surrounding tooth structures but also affect the whole-body health such as the digestive and nervous systems. Epidemiological investigations suggested that in some developed countries, more than 45% or even 50% population were suffering from periodontitis. However, the prevalence increases with age remarkably and it is investigated that a high prevalence (>50%) is affecting the elderly who is over 65 years old. There is an increasing interest in the direct and indirect relationships between periodontitis and hyperuricemia. Currently, hyperuricemia has become the second major metabolic disease in modern society and the prevalence of hyperuricemia among adult males and females was 21.7% and 14.4% respectively. As an inflammatory disease associated with various systemic diseases, periodontitis may have certain connections with hyperuricemia. Partial existing research announced that hyperuricemia could act as an inhibitory factor for periodontitis, while other scholars presented that a high uric acid (UA) level was more likely to aggravate inflammatory immune response and lead to more serious tissue destruction. This article provides a detailed and comprehensive overview of the relationship underlying hyperuricemia and periodontitis in the molecular mechanisms. Given the impact of hyperuricemia, this review could provide insight into its comorbidities.https://www.frontiersin.org/articles/10.3389/fimmu.2022.995582/fullperiodontitishyperuricemiauric acidinflammationtoll-like receptorsmonosodium urate |
| spellingShingle | Wenxue Hou Wenxue Hou Wenxue Hou Wenxue Hou Xiaomin Xia Xiaomin Xia Xiaomin Xia Xiaomin Xia Ying Li Ying Li Ying Li Ying Li Hanlin Lv Hanlin Lv Hanlin Lv Hanlin Lv Jie Liu Jie Liu Jie Liu Jie Liu Xue Li Xue Li Xue Li Xue Li Recent progress and perspectives on the relationship between hyperuricemia and periodontitis Frontiers in Immunology periodontitis hyperuricemia uric acid inflammation toll-like receptors monosodium urate |
| title | Recent progress and perspectives on the relationship between hyperuricemia and periodontitis |
| title_full | Recent progress and perspectives on the relationship between hyperuricemia and periodontitis |
| title_fullStr | Recent progress and perspectives on the relationship between hyperuricemia and periodontitis |
| title_full_unstemmed | Recent progress and perspectives on the relationship between hyperuricemia and periodontitis |
| title_short | Recent progress and perspectives on the relationship between hyperuricemia and periodontitis |
| title_sort | recent progress and perspectives on the relationship between hyperuricemia and periodontitis |
| topic | periodontitis hyperuricemia uric acid inflammation toll-like receptors monosodium urate |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.995582/full |
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