Obesity-Related Atrial Fibrillation: Cardiac Manifestation of a Systemic Disease
Atrial fibrillation (AF) is the most common arrhythmia worldwide and is associated with increased morbidity and mortality. The mechanisms underlying AF are complex and multifactorial. Although it is well known that obesity is a strong risk factor for AF, the mechanisms underlying obesity-related AF...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/10/8/323 |
| _version_ | 1827729582610972672 |
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| author | Worawan B. Limpitikul Saumya Das |
| author_facet | Worawan B. Limpitikul Saumya Das |
| author_sort | Worawan B. Limpitikul |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is the most common arrhythmia worldwide and is associated with increased morbidity and mortality. The mechanisms underlying AF are complex and multifactorial. Although it is well known that obesity is a strong risk factor for AF, the mechanisms underlying obesity-related AF are not completely understood. Current evidence proposes that in addition to overall hemodynamic changes due to increased body weight, excess adiposity raises systemic inflammation and oxidative stress, which lead to adverse atrial remodeling. This remodeling includes atrial fibrosis, atrial dilation, decreased electrical conduction between atrial myocytes, and altered ionic currents, making atrial tissue more vulnerable to both the initiation and maintenance of AF. However, much remains to be learned about the mechanistic links between obesity and AF. This knowledge will power the development of novel diagnostic tools and treatment options that will help combat the rise of the global AF burden among the obesity epidemic. |
| first_indexed | 2024-03-10T23:51:43Z |
| format | Article |
| id | doaj.art-b10fa19c6abf42fa9c3453caced9e062 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T23:51:43Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-b10fa19c6abf42fa9c3453caced9e0622023-11-19T01:37:57ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252023-07-0110832310.3390/jcdd10080323Obesity-Related Atrial Fibrillation: Cardiac Manifestation of a Systemic DiseaseWorawan B. Limpitikul0Saumya Das1Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USACardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USAAtrial fibrillation (AF) is the most common arrhythmia worldwide and is associated with increased morbidity and mortality. The mechanisms underlying AF are complex and multifactorial. Although it is well known that obesity is a strong risk factor for AF, the mechanisms underlying obesity-related AF are not completely understood. Current evidence proposes that in addition to overall hemodynamic changes due to increased body weight, excess adiposity raises systemic inflammation and oxidative stress, which lead to adverse atrial remodeling. This remodeling includes atrial fibrosis, atrial dilation, decreased electrical conduction between atrial myocytes, and altered ionic currents, making atrial tissue more vulnerable to both the initiation and maintenance of AF. However, much remains to be learned about the mechanistic links between obesity and AF. This knowledge will power the development of novel diagnostic tools and treatment options that will help combat the rise of the global AF burden among the obesity epidemic.https://www.mdpi.com/2308-3425/10/8/323atrial fibrillationobesitymetabolic syndromeadiposityatrial myopathyatrial remodeling |
| spellingShingle | Worawan B. Limpitikul Saumya Das Obesity-Related Atrial Fibrillation: Cardiac Manifestation of a Systemic Disease Journal of Cardiovascular Development and Disease atrial fibrillation obesity metabolic syndrome adiposity atrial myopathy atrial remodeling |
| title | Obesity-Related Atrial Fibrillation: Cardiac Manifestation of a Systemic Disease |
| title_full | Obesity-Related Atrial Fibrillation: Cardiac Manifestation of a Systemic Disease |
| title_fullStr | Obesity-Related Atrial Fibrillation: Cardiac Manifestation of a Systemic Disease |
| title_full_unstemmed | Obesity-Related Atrial Fibrillation: Cardiac Manifestation of a Systemic Disease |
| title_short | Obesity-Related Atrial Fibrillation: Cardiac Manifestation of a Systemic Disease |
| title_sort | obesity related atrial fibrillation cardiac manifestation of a systemic disease |
| topic | atrial fibrillation obesity metabolic syndrome adiposity atrial myopathy atrial remodeling |
| url | https://www.mdpi.com/2308-3425/10/8/323 |
| work_keys_str_mv | AT worawanblimpitikul obesityrelatedatrialfibrillationcardiacmanifestationofasystemicdisease AT saumyadas obesityrelatedatrialfibrillationcardiacmanifestationofasystemicdisease |