MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
Not all mutated cells become malignant, suggesting additional requirements for transformation. Here, the authors track blood progenitors from normal to malignancy driven by MLL-AF9, revealing a subset of myeloid progenitors predisposed to transformation dependent on their normal cycling state.
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-12-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13666-5 |
| _version_ | 1818749181417750528 |
|---|---|
| author | Xinyue Chen Daniel B. Burkhardt Amaleah A. Hartman Xiao Hu Anna E. Eastman Chao Sun Xujun Wang Mei Zhong Smita Krishnaswamy Shangqin Guo |
| author_facet | Xinyue Chen Daniel B. Burkhardt Amaleah A. Hartman Xiao Hu Anna E. Eastman Chao Sun Xujun Wang Mei Zhong Smita Krishnaswamy Shangqin Guo |
| author_sort | Xinyue Chen |
| collection | DOAJ |
| description | Not all mutated cells become malignant, suggesting additional requirements for transformation. Here, the authors track blood progenitors from normal to malignancy driven by MLL-AF9, revealing a subset of myeloid progenitors predisposed to transformation dependent on their normal cycling state. |
| first_indexed | 2024-12-18T03:59:42Z |
| format | Article |
| id | doaj.art-b111a4d94fc0407fb663f8993929840c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T03:59:42Z |
| publishDate | 2019-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b111a4d94fc0407fb663f8993929840c2022-12-21T21:21:43ZengNature PortfolioNature Communications2041-17232019-12-0110111510.1038/s41467-019-13666-5MLL-AF9 initiates transformation from fast-proliferating myeloid progenitorsXinyue Chen0Daniel B. Burkhardt1Amaleah A. Hartman2Xiao Hu3Anna E. Eastman4Chao Sun5Xujun Wang6Mei Zhong7Smita Krishnaswamy8Shangqin Guo9Department of Cell Biology, Yale UniversityDepartment of Genetics, Yale UniversityDepartment of Cell Biology, Yale UniversityDepartment of Cell Biology, Yale UniversityDepartment of Cell Biology, Yale UniversityDepartment of Cell Biology, Yale UniversitySJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong UniversityDepartment of Cell Biology, Yale UniversityDepartment of Genetics, Yale UniversityDepartment of Cell Biology, Yale UniversityNot all mutated cells become malignant, suggesting additional requirements for transformation. Here, the authors track blood progenitors from normal to malignancy driven by MLL-AF9, revealing a subset of myeloid progenitors predisposed to transformation dependent on their normal cycling state.https://doi.org/10.1038/s41467-019-13666-5 |
| spellingShingle | Xinyue Chen Daniel B. Burkhardt Amaleah A. Hartman Xiao Hu Anna E. Eastman Chao Sun Xujun Wang Mei Zhong Smita Krishnaswamy Shangqin Guo MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors Nature Communications |
| title | MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors |
| title_full | MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors |
| title_fullStr | MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors |
| title_full_unstemmed | MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors |
| title_short | MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors |
| title_sort | mll af9 initiates transformation from fast proliferating myeloid progenitors |
| url | https://doi.org/10.1038/s41467-019-13666-5 |
| work_keys_str_mv | AT xinyuechen mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors AT danielbburkhardt mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors AT amaleahahartman mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors AT xiaohu mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors AT annaeeastman mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors AT chaosun mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors AT xujunwang mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors AT meizhong mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors AT smitakrishnaswamy mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors AT shangqinguo mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors |