Severely atrophic human muscle fibers with nuclear misplacement survive many years of permanent denervation
Likewise in rodents, after complete spinal cord injury (SCI) the lower motor neuron (LMN) denervated human muscle fibers lose completely the myofibrillar apparatus and the coil distribution of myonuclei that are relocated in groups (nuclear clumps) in the center of severely atrophic muscle fibers. U...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2016-06-01
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| Series: | European Journal of Translational Myology |
| Subjects: | |
| Online Access: | http://www.pagepressjournals.org/index.php/bam/article/view/5894 |
| _version_ | 1819063367250214912 |
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| author | Ugo Carraro Helmut Kern |
| author_facet | Ugo Carraro Helmut Kern |
| author_sort | Ugo Carraro |
| collection | DOAJ |
| description | Likewise in rodents, after complete spinal cord injury (SCI) the lower motor neuron (LMN) denervated human muscle fibers lose completely the myofibrillar apparatus and the coil distribution of myonuclei that are relocated in groups (nuclear clumps) in the center of severely atrophic muscle fibers. Up to two years of LMN denervation the muscle fibers with nuclear clumps are very seldom, but in this cohort of patients the severely atrophic muscle fibers are frequent in muscle biopsies harvested three to six years after SCI. Indeed, the percentage increased to 27 ± 9% (p< 0.001), and then abruptly decreased from the 6th year onward, when fibrosis takes over to neurogenic muscle atrophy. Immunohistochemical analyses shown that nuclear misplacements occurred in both fast and slow muscle fibers. In conclusion, human muscle fibers survive permanent denervation much longer than generally accepted and relocation of nuclei is a general behavior in long term denervated muscle fibers. |
| first_indexed | 2024-12-21T15:13:33Z |
| format | Article |
| id | doaj.art-b11231b335e64656b174829713e6e956 |
| institution | Directory Open Access Journal |
| issn | 2037-7452 2037-7460 |
| language | English |
| last_indexed | 2024-12-21T15:13:33Z |
| publishDate | 2016-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Translational Myology |
| spelling | doaj.art-b11231b335e64656b174829713e6e9562022-12-21T18:59:13ZengPAGEPress PublicationsEuropean Journal of Translational Myology2037-74522037-74602016-06-0126210.4081/ejtm.2016.58944761Severely atrophic human muscle fibers with nuclear misplacement survive many years of permanent denervationUgo Carraro0Helmut Kern1IRCCS, Fondazione Ospedale San Camillo, VeniceInstitute of Physical Medicine and Rehabilitation, Wilhelminenspital, Vienna; Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation, ViennaLikewise in rodents, after complete spinal cord injury (SCI) the lower motor neuron (LMN) denervated human muscle fibers lose completely the myofibrillar apparatus and the coil distribution of myonuclei that are relocated in groups (nuclear clumps) in the center of severely atrophic muscle fibers. Up to two years of LMN denervation the muscle fibers with nuclear clumps are very seldom, but in this cohort of patients the severely atrophic muscle fibers are frequent in muscle biopsies harvested three to six years after SCI. Indeed, the percentage increased to 27 ± 9% (p< 0.001), and then abruptly decreased from the 6th year onward, when fibrosis takes over to neurogenic muscle atrophy. Immunohistochemical analyses shown that nuclear misplacements occurred in both fast and slow muscle fibers. In conclusion, human muscle fibers survive permanent denervation much longer than generally accepted and relocation of nuclei is a general behavior in long term denervated muscle fibers.http://www.pagepressjournals.org/index.php/bam/article/view/5894Human muscleLong-standing denervationNuclear clumps |
| spellingShingle | Ugo Carraro Helmut Kern Severely atrophic human muscle fibers with nuclear misplacement survive many years of permanent denervation European Journal of Translational Myology Human muscle Long-standing denervation Nuclear clumps |
| title | Severely atrophic human muscle fibers with nuclear misplacement survive many years of permanent denervation |
| title_full | Severely atrophic human muscle fibers with nuclear misplacement survive many years of permanent denervation |
| title_fullStr | Severely atrophic human muscle fibers with nuclear misplacement survive many years of permanent denervation |
| title_full_unstemmed | Severely atrophic human muscle fibers with nuclear misplacement survive many years of permanent denervation |
| title_short | Severely atrophic human muscle fibers with nuclear misplacement survive many years of permanent denervation |
| title_sort | severely atrophic human muscle fibers with nuclear misplacement survive many years of permanent denervation |
| topic | Human muscle Long-standing denervation Nuclear clumps |
| url | http://www.pagepressjournals.org/index.php/bam/article/view/5894 |
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