Mogroside derivatives exert hypoglycemics effects by decreasing blood glucose level in HepG2 cells and alleviates insulin resistance in T2DM rats

Mogroside derivatives exert hypoglycemics effects by decreasing blood glucose level in HepG2 cells and alleviates insulin resistance in T2DM rats

Mogroside, a triterpenoid of Siraitia grosvenorii, has been reported to play an important role in glycometabolism processes. In this study, the mechanism of mogroside was evaluated through in vitro experiments using Mogroside III (MO3), IV (MO4), V (MO5), Siamenoside I (SO1) at 1, 5, 10 μM, and in v...

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Bibliographic Details
Main Authors: Xuan Liu, Jingjing Zhang, Yumeng Li, Liyang Sun, Yao Xiao, Wenge Gao, Zesheng Zhang
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Journal of Functional Foods
Subjects:
Mogroside
Insulin resistance
HepG2 cells
T2DM rats
PI3K/Akt signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464619304906

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