NO-dependent protective effect of VEGF against excitotoxicity on layer VI of the developing cerebral cortex

NO-dependent protective effect of VEGF against excitotoxicity on layer VI of the developing cerebral cortex

In industrialized countries, cerebral palsy affects 2.5‰ of preterm and term infants. At a neurochemical level, the massive release of glutamate constitutes a major process leading to excitotoxicity and neonatal brain lesions. Previous studies, conducted in the laboratory, revealed that, in δ/δVEGFA...

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Main Authors: Faiza El Ghazi, Arnaud Desfeux, Carole Brasse-Lagnel, Christian Roux, Celine Lesueur, Danielle Mazur, Isabelle Remy-Jouet, Vincent Richard, Sylvie Jégou, Vincent Laudenbach, Stephane Marret, Soumeya Bekri, Vincent Prevot, Bruno J. Gonzalez
Format: Article
Language:English
Published: Elsevier 2012-03-01
Series:Neurobiology of Disease
Subjects:
Necrosis
Glutamate
Nitric oxide synthase
VEGFA
Neuroprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111003780

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