Assessment of ploidy status in oral potentially malignant disorders – A systematic review
Malignant and potentially malignant epithelial lesions are often associated with various abnormalities such as epithelial dysplasia, abnormal DNA content, loss of heterozygosity, and chromosomal number aberrations. Screening and early detection of such abnormalities facilitates proper care and also...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2023;volume=15;issue=5;spage=86;epage=92;aulast=Annapoorani |
| _version_ | 1797645514766811136 |
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| author | S Annapoorani N Gururaj V Abiraami Balambigai Nilima Prakash P Hasinidevi V Janani |
| author_facet | S Annapoorani N Gururaj V Abiraami Balambigai Nilima Prakash P Hasinidevi V Janani |
| author_sort | S Annapoorani |
| collection | DOAJ |
| description | Malignant and potentially malignant epithelial lesions are often associated with various abnormalities such as epithelial dysplasia, abnormal DNA content, loss of heterozygosity, and chromosomal number aberrations. Screening and early detection of such abnormalities facilitates proper care and also helps to prevent further progression of potentially malignant lesions to malignancy. In such way, the presence of DNA aneuploidy in oral potentially malignant disorders (OPMDs) may serve as an indicator for the malignant transforming potential. Various assessment methods have been proposed to find the DNA ploidy status of cells. This current systematic review is mainly designed to assess the importance of ploidy status in OPMD while measuring the feasibility of using this biomarker for evaluating the hazard of malignant transformation. As an upshot of this systematic review, we can conclude that use of DNA ploidy status can serve as an independent bio-marker for predicting the malignant transformation of lesions. Furthermore, as a future scope the use of DNA ploidy analysis in normal mucosa of smokers will help to assess the malignancy risk and this technique might also help to predict the genetic predisposition of patients with malignancy. |
| first_indexed | 2024-03-11T14:49:01Z |
| format | Article |
| id | doaj.art-b11842016c6243b3b63315ac06fe7d08 |
| institution | Directory Open Access Journal |
| issn | 0975-7406 |
| language | English |
| last_indexed | 2024-03-11T14:49:01Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-b11842016c6243b3b63315ac06fe7d082023-10-30T10:31:53ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74062023-01-01155869210.4103/jpbs.jpbs_547_22Assessment of ploidy status in oral potentially malignant disorders – A systematic reviewS AnnapooraniN GururajV Abiraami BalambigaiNilima PrakashP HasinideviV JananiMalignant and potentially malignant epithelial lesions are often associated with various abnormalities such as epithelial dysplasia, abnormal DNA content, loss of heterozygosity, and chromosomal number aberrations. Screening and early detection of such abnormalities facilitates proper care and also helps to prevent further progression of potentially malignant lesions to malignancy. In such way, the presence of DNA aneuploidy in oral potentially malignant disorders (OPMDs) may serve as an indicator for the malignant transforming potential. Various assessment methods have been proposed to find the DNA ploidy status of cells. This current systematic review is mainly designed to assess the importance of ploidy status in OPMD while measuring the feasibility of using this biomarker for evaluating the hazard of malignant transformation. As an upshot of this systematic review, we can conclude that use of DNA ploidy status can serve as an independent bio-marker for predicting the malignant transformation of lesions. Furthermore, as a future scope the use of DNA ploidy analysis in normal mucosa of smokers will help to assess the malignancy risk and this technique might also help to predict the genetic predisposition of patients with malignancy.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2023;volume=15;issue=5;spage=86;epage=92;aulast=Annapooranibio-markerbrush biopsydna ploidyimage cytometrymalignancyopmd |
| spellingShingle | S Annapoorani N Gururaj V Abiraami Balambigai Nilima Prakash P Hasinidevi V Janani Assessment of ploidy status in oral potentially malignant disorders – A systematic review Journal of Pharmacy and Bioallied Sciences bio-marker brush biopsy dna ploidy image cytometry malignancy opmd |
| title | Assessment of ploidy status in oral potentially malignant disorders – A systematic review |
| title_full | Assessment of ploidy status in oral potentially malignant disorders – A systematic review |
| title_fullStr | Assessment of ploidy status in oral potentially malignant disorders – A systematic review |
| title_full_unstemmed | Assessment of ploidy status in oral potentially malignant disorders – A systematic review |
| title_short | Assessment of ploidy status in oral potentially malignant disorders – A systematic review |
| title_sort | assessment of ploidy status in oral potentially malignant disorders a systematic review |
| topic | bio-marker brush biopsy dna ploidy image cytometry malignancy opmd |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2023;volume=15;issue=5;spage=86;epage=92;aulast=Annapoorani |
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