Methyl Aminolaevulinic Acid versus Aminolaevulinic Acid Photodynamic Therapy of Actinic Keratosis with Low Doses of Red-Light LED Illumination: Results of Long-Term Follow-Up
Photodynamic therapy (PDT) treatment for multiple actinic keratosis (AK) has been found effective when lower doses of red light were used with methyl aminolaevulinic acid (MAL). The aim of this study was to compare the results of lower doses of red light conventional PDT (h-PDT, 16 J/cm<sup>2&...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/12/3218 |
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| author | Montserrat Fernández Guarino Diego Fernández-Nieto Laura Vila Montes Dario de Perosanz Lobo |
| author_facet | Montserrat Fernández Guarino Diego Fernández-Nieto Laura Vila Montes Dario de Perosanz Lobo |
| author_sort | Montserrat Fernández Guarino |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) treatment for multiple actinic keratosis (AK) has been found effective when lower doses of red light were used with methyl aminolaevulinic acid (MAL). The aim of this study was to compare the results of lower doses of red light conventional PDT (h-PDT, 16 J/cm<sup>2</sup>) with MAL and aminolaevulinic acid (ALA) in a long-term follow-up. Patients with more than five symmetrical AK on the scalp who were candidates for PDT were selected and divided randomly between MAL and ALA treatment and patients were followed at 3 and 12 months. The responses were assessed by counting the total AK and the AK per patient. Pain and adverse events were also compiled. A total of 46 patients were treated, 24 with MAL, and 22 with ALA. The two groups were comparable at baseline (<i>p</i> > 0.005). No significant differences were found in the results of both treatments at 12 months, despite ALA exhibiting slightly better results at 3 months. No differences in pain and adverse events were assessed. Both ALA and MAL were effective when lower doses of red light were used in c-PDT. Long term efficacy was also documented. Further studies are necessary to determine the inferior point of red-light illumination without losing efficacy. |
| first_indexed | 2024-03-09T17:17:34Z |
| format | Article |
| id | doaj.art-b1184e2098c64ce7873c2c4bceeb841d |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T17:17:34Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-b1184e2098c64ce7873c2c4bceeb841d2023-11-24T13:28:53ZengMDPI AGBiomedicines2227-90592022-12-011012321810.3390/biomedicines10123218Methyl Aminolaevulinic Acid versus Aminolaevulinic Acid Photodynamic Therapy of Actinic Keratosis with Low Doses of Red-Light LED Illumination: Results of Long-Term Follow-UpMontserrat Fernández Guarino0Diego Fernández-Nieto1Laura Vila Montes2Dario de Perosanz Lobo3Hospital Universitario Ramón y Cajal, Instituto de Investigación Sanitaria Irycis, 28034 Madrid, SpainHospital Universitario Ramón y Cajal, Instituto de Investigación Sanitaria Irycis, 28034 Madrid, SpainHospital Universitario Ramón y Cajal, Instituto de Investigación Sanitaria Irycis, 28034 Madrid, SpainHospital Universitario Ramón y Cajal, Instituto de Investigación Sanitaria Irycis, 28034 Madrid, SpainPhotodynamic therapy (PDT) treatment for multiple actinic keratosis (AK) has been found effective when lower doses of red light were used with methyl aminolaevulinic acid (MAL). The aim of this study was to compare the results of lower doses of red light conventional PDT (h-PDT, 16 J/cm<sup>2</sup>) with MAL and aminolaevulinic acid (ALA) in a long-term follow-up. Patients with more than five symmetrical AK on the scalp who were candidates for PDT were selected and divided randomly between MAL and ALA treatment and patients were followed at 3 and 12 months. The responses were assessed by counting the total AK and the AK per patient. Pain and adverse events were also compiled. A total of 46 patients were treated, 24 with MAL, and 22 with ALA. The two groups were comparable at baseline (<i>p</i> > 0.005). No significant differences were found in the results of both treatments at 12 months, despite ALA exhibiting slightly better results at 3 months. No differences in pain and adverse events were assessed. Both ALA and MAL were effective when lower doses of red light were used in c-PDT. Long term efficacy was also documented. Further studies are necessary to determine the inferior point of red-light illumination without losing efficacy.https://www.mdpi.com/2227-9059/10/12/3218photodynamic therapyred lightshort illumination |
| spellingShingle | Montserrat Fernández Guarino Diego Fernández-Nieto Laura Vila Montes Dario de Perosanz Lobo Methyl Aminolaevulinic Acid versus Aminolaevulinic Acid Photodynamic Therapy of Actinic Keratosis with Low Doses of Red-Light LED Illumination: Results of Long-Term Follow-Up Biomedicines photodynamic therapy red light short illumination |
| title | Methyl Aminolaevulinic Acid versus Aminolaevulinic Acid Photodynamic Therapy of Actinic Keratosis with Low Doses of Red-Light LED Illumination: Results of Long-Term Follow-Up |
| title_full | Methyl Aminolaevulinic Acid versus Aminolaevulinic Acid Photodynamic Therapy of Actinic Keratosis with Low Doses of Red-Light LED Illumination: Results of Long-Term Follow-Up |
| title_fullStr | Methyl Aminolaevulinic Acid versus Aminolaevulinic Acid Photodynamic Therapy of Actinic Keratosis with Low Doses of Red-Light LED Illumination: Results of Long-Term Follow-Up |
| title_full_unstemmed | Methyl Aminolaevulinic Acid versus Aminolaevulinic Acid Photodynamic Therapy of Actinic Keratosis with Low Doses of Red-Light LED Illumination: Results of Long-Term Follow-Up |
| title_short | Methyl Aminolaevulinic Acid versus Aminolaevulinic Acid Photodynamic Therapy of Actinic Keratosis with Low Doses of Red-Light LED Illumination: Results of Long-Term Follow-Up |
| title_sort | methyl aminolaevulinic acid versus aminolaevulinic acid photodynamic therapy of actinic keratosis with low doses of red light led illumination results of long term follow up |
| topic | photodynamic therapy red light short illumination |
| url | https://www.mdpi.com/2227-9059/10/12/3218 |
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