ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation

ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation

Women have increased prevalence of Th17-mediated autoimmune diseases, including lupus and multiple sclerosis, and severe asthma. While estradiol and progesterone increased IL-17A production in Th17 cells by inhibiting Let7f miRNA expression and increasing IL-23 receptor (IL-23R) expression, it remai...

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Bibliographic Details
Main Authors: Hubaida Fuseini, Jacqueline-Yvonne Cephus, Pingsheng Wu, J. Brooke Davis, Diana C. Contreras, Vivek D. Gandhi, Jeffrey C. Rathmell, Dawn C. Newcomb
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
Th17
estrogen receptor alpha
IL-23R
IL-17A
cytochrome c oxidase
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02740/full

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