Oral Microbiota—A New Frontier in the Pathogenesis and Management of Head and Neck Cancers
Head and neck squamous cell carcinoma (HNSCC) comprises the majority of tumors in head and neck tissues. The prognosis of HNSCC has not significantly improved for decades, signifying the need for new diagnostic and therapeutic targets. Recent evidence suggests that oral microbiota is associated with...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/1/46 |
| _version_ | 1797499451323973632 |
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| author | Marjut Metsäniitty Shrabon Hasnat Tuula Salo Abdelhakim Salem |
| author_facet | Marjut Metsäniitty Shrabon Hasnat Tuula Salo Abdelhakim Salem |
| author_sort | Marjut Metsäniitty |
| collection | DOAJ |
| description | Head and neck squamous cell carcinoma (HNSCC) comprises the majority of tumors in head and neck tissues. The prognosis of HNSCC has not significantly improved for decades, signifying the need for new diagnostic and therapeutic targets. Recent evidence suggests that oral microbiota is associated with carcinogenesis. Thus, we conducted a comprehensive systematic review to evaluate the current evidence regarding the role of oral microbiota in HNSCC and whether their targeting may confer diagnostic, prognostic or therapeutic utility. Following the screening of 233 publications retrieved from multiple databases, 34 eligible studies comprising 2469 patients were compiled and critically appraised. Importantly, many oral pathogens, such as <i>Porphyromonas gingivalis</i> and <i>Fusobacterium nucleatum</i> were linked to certain oral potentially malignant lesions and various types of HNSCC. Furthermore, we summarized the association between the expression profiles of different oral bacterial species and their tumorigenic and prognostic effects in cancer patients. We also discussed the current limitations of this newly emerging area and the potential microbiota-related strategies for preventing and treating HNSCC. Whilst many clinical studies are underway to unravel the role of oral microbiota in cancer, the limited available data and experimental approaches reflect the newness of this promising yet challenging field. |
| first_indexed | 2024-03-10T03:47:33Z |
| format | Article |
| id | doaj.art-b11d6ebbf55045328991a3c8d823ba5d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T03:47:33Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b11d6ebbf55045328991a3c8d823ba5d2023-11-23T11:15:14ZengMDPI AGCancers2072-66942021-12-011414610.3390/cancers14010046Oral Microbiota—A New Frontier in the Pathogenesis and Management of Head and Neck CancersMarjut Metsäniitty0Shrabon Hasnat1Tuula Salo2Abdelhakim Salem3Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, 00014 Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, 00014 Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, 00014 Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, 00014 Helsinki, FinlandHead and neck squamous cell carcinoma (HNSCC) comprises the majority of tumors in head and neck tissues. The prognosis of HNSCC has not significantly improved for decades, signifying the need for new diagnostic and therapeutic targets. Recent evidence suggests that oral microbiota is associated with carcinogenesis. Thus, we conducted a comprehensive systematic review to evaluate the current evidence regarding the role of oral microbiota in HNSCC and whether their targeting may confer diagnostic, prognostic or therapeutic utility. Following the screening of 233 publications retrieved from multiple databases, 34 eligible studies comprising 2469 patients were compiled and critically appraised. Importantly, many oral pathogens, such as <i>Porphyromonas gingivalis</i> and <i>Fusobacterium nucleatum</i> were linked to certain oral potentially malignant lesions and various types of HNSCC. Furthermore, we summarized the association between the expression profiles of different oral bacterial species and their tumorigenic and prognostic effects in cancer patients. We also discussed the current limitations of this newly emerging area and the potential microbiota-related strategies for preventing and treating HNSCC. Whilst many clinical studies are underway to unravel the role of oral microbiota in cancer, the limited available data and experimental approaches reflect the newness of this promising yet challenging field.https://www.mdpi.com/2072-6694/14/1/46microbiomeDNA/RNA sequencingcancerhead and neck squamous cell carcinomametastasisbiomarker |
| spellingShingle | Marjut Metsäniitty Shrabon Hasnat Tuula Salo Abdelhakim Salem Oral Microbiota—A New Frontier in the Pathogenesis and Management of Head and Neck Cancers Cancers microbiome DNA/RNA sequencing cancer head and neck squamous cell carcinoma metastasis biomarker |
| title | Oral Microbiota—A New Frontier in the Pathogenesis and Management of Head and Neck Cancers |
| title_full | Oral Microbiota—A New Frontier in the Pathogenesis and Management of Head and Neck Cancers |
| title_fullStr | Oral Microbiota—A New Frontier in the Pathogenesis and Management of Head and Neck Cancers |
| title_full_unstemmed | Oral Microbiota—A New Frontier in the Pathogenesis and Management of Head and Neck Cancers |
| title_short | Oral Microbiota—A New Frontier in the Pathogenesis and Management of Head and Neck Cancers |
| title_sort | oral microbiota a new frontier in the pathogenesis and management of head and neck cancers |
| topic | microbiome DNA/RNA sequencing cancer head and neck squamous cell carcinoma metastasis biomarker |
| url | https://www.mdpi.com/2072-6694/14/1/46 |
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