The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus
Abstract Dioxins are highly toxic to foetuses and prenatal exposure leads to adverse health effects; however, the metabolic pathways involved in dioxin excretion are poorly understood. We determined the dynamics of maternal-to-foetal dioxin transfer during normal pregnancy and how foetuses eliminate...
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| Format: | Article |
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Nature Portfolio
2017-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-00863-9 |
| _version_ | 1828970447067152384 |
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| author | Seiichi Morokuma Kiyomi Tsukimori Tsuguhide Hori Kiyoko Kato Masutaka Furue |
| author_facet | Seiichi Morokuma Kiyomi Tsukimori Tsuguhide Hori Kiyoko Kato Masutaka Furue |
| author_sort | Seiichi Morokuma |
| collection | DOAJ |
| description | Abstract Dioxins are highly toxic to foetuses and prenatal exposure leads to adverse health effects; however, the metabolic pathways involved in dioxin excretion are poorly understood. We determined the dynamics of maternal-to-foetal dioxin transfer during normal pregnancy and how foetuses eliminate polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and non-ortho polychlorinated biphenyls. Dioxin levels in maternal blood, cord blood, placenta, vernix caseosa, meconium, and amniotic fluid were analysed by high-resolution gas chromatography/mass spectrometry. The average levels of total dioxins, expressed as picograms of toxic equivalency quantity per gram of lipid and in parentheses, dioxin fraction, with maternal blood levels arbitrarily set as 100%, were as follows: maternal blood, 15.8 (100%); placenta, 12.9 (81.5%); cord blood, 5.9 (37.2%); vernix caseosa, 8.4 (53.2%); meconium, 2.9 (18.2%); and amniotic fluid, 1.5 (9.2%). Similar proportions were observed for each dioxin congener. Thus, the highest content of foetal dioxins was observed in the vernix caseosa, indicating that this is the major site of dioxin excretion in human foetuses. |
| first_indexed | 2024-12-14T12:50:10Z |
| format | Article |
| id | doaj.art-b11edf4da90046c483fca726bf0fe530 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T12:50:10Z |
| publishDate | 2017-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b11edf4da90046c483fca726bf0fe5302022-12-21T23:00:41ZengNature PortfolioScientific Reports2045-23222017-04-01711410.1038/s41598-017-00863-9The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human FoetusSeiichi Morokuma0Kiyomi Tsukimori1Tsuguhide Hori2Kiyoko Kato3Masutaka Furue4Department of Obstetrics and Gynecology, Kyushu University HospitalDepartment of Obstetrics, Fukuoka Children’s HospitalFukuoka Institute of Health and Environmental ScienceDepartment of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu UniversityResearch and Clinical Center for Yusho and Dioxin, Kyushu University HospitalAbstract Dioxins are highly toxic to foetuses and prenatal exposure leads to adverse health effects; however, the metabolic pathways involved in dioxin excretion are poorly understood. We determined the dynamics of maternal-to-foetal dioxin transfer during normal pregnancy and how foetuses eliminate polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and non-ortho polychlorinated biphenyls. Dioxin levels in maternal blood, cord blood, placenta, vernix caseosa, meconium, and amniotic fluid were analysed by high-resolution gas chromatography/mass spectrometry. The average levels of total dioxins, expressed as picograms of toxic equivalency quantity per gram of lipid and in parentheses, dioxin fraction, with maternal blood levels arbitrarily set as 100%, were as follows: maternal blood, 15.8 (100%); placenta, 12.9 (81.5%); cord blood, 5.9 (37.2%); vernix caseosa, 8.4 (53.2%); meconium, 2.9 (18.2%); and amniotic fluid, 1.5 (9.2%). Similar proportions were observed for each dioxin congener. Thus, the highest content of foetal dioxins was observed in the vernix caseosa, indicating that this is the major site of dioxin excretion in human foetuses.https://doi.org/10.1038/s41598-017-00863-9 |
| spellingShingle | Seiichi Morokuma Kiyomi Tsukimori Tsuguhide Hori Kiyoko Kato Masutaka Furue The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus Scientific Reports |
| title | The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus |
| title_full | The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus |
| title_fullStr | The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus |
| title_full_unstemmed | The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus |
| title_short | The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus |
| title_sort | vernix caseosa is the main site of dioxin excretion in the human foetus |
| url | https://doi.org/10.1038/s41598-017-00863-9 |
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