Role of pyroptosis in hemostasis activation in sepsis
Sepsis is frequently associated with hemostasis activation and thrombus formation, and systematic hemostatic changes are associated with a higher risk of mortality. The key events underlying hemostasis activation during sepsis are the strong activation of innate immune pathways and the excessive inf...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1114917/full |
| _version_ | 1797945488978214912 |
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| author | Chengrui Zhu Yingjian Liang Yangtuo Luo Xiaochun Ma |
| author_facet | Chengrui Zhu Yingjian Liang Yangtuo Luo Xiaochun Ma |
| author_sort | Chengrui Zhu |
| collection | DOAJ |
| description | Sepsis is frequently associated with hemostasis activation and thrombus formation, and systematic hemostatic changes are associated with a higher risk of mortality. The key events underlying hemostasis activation during sepsis are the strong activation of innate immune pathways and the excessive inflammatory response triggered by invading pathogens. Pyroptosis is a proinflammatory form of programmed cell death, that defends against pathogens during sepsis. However, excessive pyroptosis can lead to a dysregulation of host immune responses and organ dysfunction. Recently, pyroptosis has been demonstrated to play a prominent role in hemostasis activation in sepsis. Several studies have demonstrated that pyroptosis participates in the release and coagulation activity of tissue factors. In addition, pyroptosis activates leukocytes, endothelial cells, platelets, which cooperate with the coagulation cascade, leading to hemostasis activation in sepsis. This review article attempts to interpret the molecular and cellular mechanisms of the hemostatic imbalance induced by pyroptosis during sepsis and discusses potential therapeutic strategies. |
| first_indexed | 2024-04-10T20:55:55Z |
| format | Article |
| id | doaj.art-b12301f7ccc2411d84676087640e7854 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T20:55:55Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b12301f7ccc2411d84676087640e78542023-01-23T04:59:08ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-01-011410.3389/fimmu.2023.11149171114917Role of pyroptosis in hemostasis activation in sepsisChengrui Zhu0Yingjian Liang1Yangtuo Luo2Xiaochun Ma3Department of Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Otolaryngology, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaSepsis is frequently associated with hemostasis activation and thrombus formation, and systematic hemostatic changes are associated with a higher risk of mortality. The key events underlying hemostasis activation during sepsis are the strong activation of innate immune pathways and the excessive inflammatory response triggered by invading pathogens. Pyroptosis is a proinflammatory form of programmed cell death, that defends against pathogens during sepsis. However, excessive pyroptosis can lead to a dysregulation of host immune responses and organ dysfunction. Recently, pyroptosis has been demonstrated to play a prominent role in hemostasis activation in sepsis. Several studies have demonstrated that pyroptosis participates in the release and coagulation activity of tissue factors. In addition, pyroptosis activates leukocytes, endothelial cells, platelets, which cooperate with the coagulation cascade, leading to hemostasis activation in sepsis. This review article attempts to interpret the molecular and cellular mechanisms of the hemostatic imbalance induced by pyroptosis during sepsis and discusses potential therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1114917/fullpyroptosisinflammasomecoagulationhemostasissepsistissue factor |
| spellingShingle | Chengrui Zhu Yingjian Liang Yangtuo Luo Xiaochun Ma Role of pyroptosis in hemostasis activation in sepsis Frontiers in Immunology pyroptosis inflammasome coagulation hemostasis sepsis tissue factor |
| title | Role of pyroptosis in hemostasis activation in sepsis |
| title_full | Role of pyroptosis in hemostasis activation in sepsis |
| title_fullStr | Role of pyroptosis in hemostasis activation in sepsis |
| title_full_unstemmed | Role of pyroptosis in hemostasis activation in sepsis |
| title_short | Role of pyroptosis in hemostasis activation in sepsis |
| title_sort | role of pyroptosis in hemostasis activation in sepsis |
| topic | pyroptosis inflammasome coagulation hemostasis sepsis tissue factor |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1114917/full |
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