Hormonal-metabolic patterns disorders of bone tissue mineralization in children with celiac disease
The review presents information about the pathophysiological mechanisms underlying disorders of the processes of mineralization of bone tissue in patients with celiac disease. The attention is focused on the role of vitamin D and its active metabolite calcitriol, and also parathyroid hormone in regu...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Remedium Group LLC
2017-12-01
|
| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/1694 |
| _version_ | 1827962089936781312 |
|---|---|
| author | L. Ya. Klimov L. M. Abramskaya M. V. Stoyan V. A. Кuryaninova S. V. Dolbnya A. N. Каsyanova R. A. Atanesyan E. S. Gerasimenko A. V. Yagupovа D. V. Bobryshev |
| author_facet | L. Ya. Klimov L. M. Abramskaya M. V. Stoyan V. A. Кuryaninova S. V. Dolbnya A. N. Каsyanova R. A. Atanesyan E. S. Gerasimenko A. V. Yagupovа D. V. Bobryshev |
| author_sort | L. Ya. Klimov |
| collection | DOAJ |
| description | The review presents information about the pathophysiological mechanisms underlying disorders of the processes of mineralization of bone tissue in patients with celiac disease. The attention is focused on the role of vitamin D and its active metabolite calcitriol, and also parathyroid hormone in regulating calcium-phosphorus metabolism, which is carried out in target organs – small intestine, kidney, bone tissue. Atrophy of the intestinal mucosa in celiac disease is accompanied not only by malabsorption of calcium, and increased resorption of bone due to increased concentration of PTG. According to various studies on the background of developing the osteoporosis in celiac disease, the risk of bone fractures is significantly increased in patients. Strict adherence to a gluten-free diet allows to normalize both the absorption of calcium, and impaired hormonal mechanisms in bone remodeling in the acute phase, and can reduce the risks of osteoporosis and pathological fractures in patients with celiac disease. |
| first_indexed | 2024-04-09T16:37:01Z |
| format | Article |
| id | doaj.art-b12323fd6f424145944190a122fe28e6 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:37:01Z |
| publishDate | 2017-12-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-b12323fd6f424145944190a122fe28e62023-04-23T06:56:52ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902017-12-010114915410.21518/2079-701X-2017-1-149-1541681Hormonal-metabolic patterns disorders of bone tissue mineralization in children with celiac diseaseL. Ya. Klimov0L. M. Abramskaya1M. V. Stoyan2V. A. Кuryaninova3S. V. Dolbnya4A. N. Каsyanova5R. A. Atanesyan6E. S. Gerasimenko7A. V. Yagupovа8D. V. Bobryshev9Stavropol State Medical UniversityStavropol State Medical UniversityStavropol State Medical University; Children Clinical Hospital by named G.К. Philippsky, StavropolStavropol State Medical University; Children Clinical Hospital by named G.К. Philippsky, StavropolStavropol State Medical UniversityStavropol State Medical UniversityStavropol State Medical UniversityStavropol State Medical UniversityStavropol State Medical UniversityStavropol State Medical UniversityThe review presents information about the pathophysiological mechanisms underlying disorders of the processes of mineralization of bone tissue in patients with celiac disease. The attention is focused on the role of vitamin D and its active metabolite calcitriol, and also parathyroid hormone in regulating calcium-phosphorus metabolism, which is carried out in target organs – small intestine, kidney, bone tissue. Atrophy of the intestinal mucosa in celiac disease is accompanied not only by malabsorption of calcium, and increased resorption of bone due to increased concentration of PTG. According to various studies on the background of developing the osteoporosis in celiac disease, the risk of bone fractures is significantly increased in patients. Strict adherence to a gluten-free diet allows to normalize both the absorption of calcium, and impaired hormonal mechanisms in bone remodeling in the acute phase, and can reduce the risks of osteoporosis and pathological fractures in patients with celiac disease.https://www.med-sovet.pro/jour/article/view/1694bone tissuedisorders of mineralizationvitamin dcalcitriolceliac disease |
| spellingShingle | L. Ya. Klimov L. M. Abramskaya M. V. Stoyan V. A. Кuryaninova S. V. Dolbnya A. N. Каsyanova R. A. Atanesyan E. S. Gerasimenko A. V. Yagupovа D. V. Bobryshev Hormonal-metabolic patterns disorders of bone tissue mineralization in children with celiac disease Медицинский совет bone tissue disorders of mineralization vitamin d calcitriol celiac disease |
| title | Hormonal-metabolic patterns disorders of bone tissue mineralization in children with celiac disease |
| title_full | Hormonal-metabolic patterns disorders of bone tissue mineralization in children with celiac disease |
| title_fullStr | Hormonal-metabolic patterns disorders of bone tissue mineralization in children with celiac disease |
| title_full_unstemmed | Hormonal-metabolic patterns disorders of bone tissue mineralization in children with celiac disease |
| title_short | Hormonal-metabolic patterns disorders of bone tissue mineralization in children with celiac disease |
| title_sort | hormonal metabolic patterns disorders of bone tissue mineralization in children with celiac disease |
| topic | bone tissue disorders of mineralization vitamin d calcitriol celiac disease |
| url | https://www.med-sovet.pro/jour/article/view/1694 |
| work_keys_str_mv | AT lyaklimov hormonalmetabolicpatternsdisordersofbonetissuemineralizationinchildrenwithceliacdisease AT lmabramskaya hormonalmetabolicpatternsdisordersofbonetissuemineralizationinchildrenwithceliacdisease AT mvstoyan hormonalmetabolicpatternsdisordersofbonetissuemineralizationinchildrenwithceliacdisease AT vakuryaninova hormonalmetabolicpatternsdisordersofbonetissuemineralizationinchildrenwithceliacdisease AT svdolbnya hormonalmetabolicpatternsdisordersofbonetissuemineralizationinchildrenwithceliacdisease AT ankasyanova hormonalmetabolicpatternsdisordersofbonetissuemineralizationinchildrenwithceliacdisease AT raatanesyan hormonalmetabolicpatternsdisordersofbonetissuemineralizationinchildrenwithceliacdisease AT esgerasimenko hormonalmetabolicpatternsdisordersofbonetissuemineralizationinchildrenwithceliacdisease AT avyagupova hormonalmetabolicpatternsdisordersofbonetissuemineralizationinchildrenwithceliacdisease AT dvbobryshev hormonalmetabolicpatternsdisordersofbonetissuemineralizationinchildrenwithceliacdisease |