Intracellular glycogen accumulation by human gut commensals as a niche adaptation trait
ABSTRACTThe human gut microbiota is a key contributor to host metabolism and physiology, thereby impacting in various ways on host health. This complex microbial community has developed many metabolic strategies to colonize, persist and survive in the gastrointestinal environment. In this regard, in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2235067 |
| _version_ | 1797236674872213504 |
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| author | Maria Esteban-Torres Lorena Ruiz Valerio Rossini Ken Nally Douwe van Sinderen |
| author_facet | Maria Esteban-Torres Lorena Ruiz Valerio Rossini Ken Nally Douwe van Sinderen |
| author_sort | Maria Esteban-Torres |
| collection | DOAJ |
| description | ABSTRACTThe human gut microbiota is a key contributor to host metabolism and physiology, thereby impacting in various ways on host health. This complex microbial community has developed many metabolic strategies to colonize, persist and survive in the gastrointestinal environment. In this regard, intracellular glycogen accumulation has been associated with important physiological functions in several bacterial species, including gut commensals. However, the role of glycogen storage in shaping the composition and functionality of the gut microbiota offers a novel perspective in gut microbiome research. Here, we review what is known about the enzymatic machinery and regulation of glycogen metabolism in selected enteric bacteria, while we also discuss its potential impact on colonization and adaptation to the gastrointestinal tract. Furthermore, we survey the presence of such glycogen biosynthesis pathways in gut metagenomic data to highlight the relevance of this metabolic trait in enhancing survival in the highly competitive and dynamic gut ecosystem. |
| first_indexed | 2024-03-11T14:20:39Z |
| format | Article |
| id | doaj.art-b1246933598342d18fe7611905aa3a9b |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-24T17:07:37Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-b1246933598342d18fe7611905aa3a9b2024-03-28T22:38:20ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115110.1080/19490976.2023.2235067Intracellular glycogen accumulation by human gut commensals as a niche adaptation traitMaria Esteban-Torres0Lorena Ruiz1Valerio Rossini2Ken Nally3Douwe van Sinderen4APC Microbiome Ireland, University College Cork, Cork, IrelandDepartment of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias, IPLA-CSIC, Villaviciosa, SpainAPC Microbiome Ireland, University College Cork, Cork, IrelandAPC Microbiome Ireland, University College Cork, Cork, IrelandAPC Microbiome Ireland, University College Cork, Cork, IrelandABSTRACTThe human gut microbiota is a key contributor to host metabolism and physiology, thereby impacting in various ways on host health. This complex microbial community has developed many metabolic strategies to colonize, persist and survive in the gastrointestinal environment. In this regard, intracellular glycogen accumulation has been associated with important physiological functions in several bacterial species, including gut commensals. However, the role of glycogen storage in shaping the composition and functionality of the gut microbiota offers a novel perspective in gut microbiome research. Here, we review what is known about the enzymatic machinery and regulation of glycogen metabolism in selected enteric bacteria, while we also discuss its potential impact on colonization and adaptation to the gastrointestinal tract. Furthermore, we survey the presence of such glycogen biosynthesis pathways in gut metagenomic data to highlight the relevance of this metabolic trait in enhancing survival in the highly competitive and dynamic gut ecosystem.https://www.tandfonline.com/doi/10.1080/19490976.2023.2235067glycogen metabolismcommensal bacteriagut microbiotacolonization factorsbacteria-host interactionsmicrobiome |
| spellingShingle | Maria Esteban-Torres Lorena Ruiz Valerio Rossini Ken Nally Douwe van Sinderen Intracellular glycogen accumulation by human gut commensals as a niche adaptation trait Gut Microbes glycogen metabolism commensal bacteria gut microbiota colonization factors bacteria-host interactions microbiome |
| title | Intracellular glycogen accumulation by human gut commensals as a niche adaptation trait |
| title_full | Intracellular glycogen accumulation by human gut commensals as a niche adaptation trait |
| title_fullStr | Intracellular glycogen accumulation by human gut commensals as a niche adaptation trait |
| title_full_unstemmed | Intracellular glycogen accumulation by human gut commensals as a niche adaptation trait |
| title_short | Intracellular glycogen accumulation by human gut commensals as a niche adaptation trait |
| title_sort | intracellular glycogen accumulation by human gut commensals as a niche adaptation trait |
| topic | glycogen metabolism commensal bacteria gut microbiota colonization factors bacteria-host interactions microbiome |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2235067 |
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