<i>Clostridioides difficile</i> Infection in Patients after Organ Transplantation—A Narrative Overview
<i>Clostridioides difficile</i> infection (CDI) is one of the most common causes of antibiotic-associated diarrhea. The pathogenesis of this infection participates in the unstable colonization of the intestines with the physiological microbiota. Solid-organ-transplant (SOT) patients and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/15/4365 |
| _version_ | 1797413473031815168 |
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| author | Sylwia Dudzicz-Gojowy Andrzej Więcek Marcin Adamczak |
| author_facet | Sylwia Dudzicz-Gojowy Andrzej Więcek Marcin Adamczak |
| author_sort | Sylwia Dudzicz-Gojowy |
| collection | DOAJ |
| description | <i>Clostridioides difficile</i> infection (CDI) is one of the most common causes of antibiotic-associated diarrhea. The pathogenesis of this infection participates in the unstable colonization of the intestines with the physiological microbiota. Solid-organ-transplant (SOT) patients and patients after hematopoietic stem cell transplantation are more prone to CDI compared to the general population. The main CDI risk factors in these patients are immunosuppressive therapy and frequent antibiotic use leading to dysbiosis. The current review article provides information about the risk factors, incidence and course of CDI in patients after liver, kidney, heart and lung transplantation and hematopoietic stem cell transplantation. |
| first_indexed | 2024-03-09T05:19:30Z |
| format | Article |
| id | doaj.art-b1259d014a1a4f509538fedd4432745a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T05:19:30Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b1259d014a1a4f509538fedd4432745a2023-12-03T12:42:46ZengMDPI AGJournal of Clinical Medicine2077-03832022-07-011115436510.3390/jcm11154365<i>Clostridioides difficile</i> Infection in Patients after Organ Transplantation—A Narrative OverviewSylwia Dudzicz-Gojowy0Andrzej Więcek1Marcin Adamczak2Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20-24, 40-027 Katowice, PolandDepartment of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20-24, 40-027 Katowice, PolandDepartment of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20-24, 40-027 Katowice, Poland<i>Clostridioides difficile</i> infection (CDI) is one of the most common causes of antibiotic-associated diarrhea. The pathogenesis of this infection participates in the unstable colonization of the intestines with the physiological microbiota. Solid-organ-transplant (SOT) patients and patients after hematopoietic stem cell transplantation are more prone to CDI compared to the general population. The main CDI risk factors in these patients are immunosuppressive therapy and frequent antibiotic use leading to dysbiosis. The current review article provides information about the risk factors, incidence and course of CDI in patients after liver, kidney, heart and lung transplantation and hematopoietic stem cell transplantation.https://www.mdpi.com/2077-0383/11/15/4365<i>Clostridioides difficile</i> infectionsolid-organ transplantationhematopoietic stem cell transplantation |
| spellingShingle | Sylwia Dudzicz-Gojowy Andrzej Więcek Marcin Adamczak <i>Clostridioides difficile</i> Infection in Patients after Organ Transplantation—A Narrative Overview Journal of Clinical Medicine <i>Clostridioides difficile</i> infection solid-organ transplantation hematopoietic stem cell transplantation |
| title | <i>Clostridioides difficile</i> Infection in Patients after Organ Transplantation—A Narrative Overview |
| title_full | <i>Clostridioides difficile</i> Infection in Patients after Organ Transplantation—A Narrative Overview |
| title_fullStr | <i>Clostridioides difficile</i> Infection in Patients after Organ Transplantation—A Narrative Overview |
| title_full_unstemmed | <i>Clostridioides difficile</i> Infection in Patients after Organ Transplantation—A Narrative Overview |
| title_short | <i>Clostridioides difficile</i> Infection in Patients after Organ Transplantation—A Narrative Overview |
| title_sort | i clostridioides difficile i infection in patients after organ transplantation a narrative overview |
| topic | <i>Clostridioides difficile</i> infection solid-organ transplantation hematopoietic stem cell transplantation |
| url | https://www.mdpi.com/2077-0383/11/15/4365 |
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