Engineering of Doxorubicin-Encapsulating and TRAIL-Conjugated Poly(RGD) Proteinoid Nanocapsules for Drug Delivery Applications

Engineering of Doxorubicin-Encapsulating and TRAIL-Conjugated Poly(RGD) Proteinoid Nanocapsules for Drug Delivery Applications

Proteinoids are non-toxic biodegradable polymers prepared by thermal step-growth polymerization of amino acids. Here, P(RGD) proteinoids and proteinoid nanocapsules (NCs) based on D-arginine, glycine, and L-aspartic acid were synthesized and characterized for targeted tumor therapy. Doxorubicin (Dox...

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Bibliographic Details
Main Authors: Elad Hadad, Safra Rudnick-Glick, Ella Itzhaki, Matan Y. Avivi, Igor Grinberg, Yuval Elias, Shlomo Margel
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Polymers
Subjects:
RGD
proteinoid
doxorubicin
TRAIL
Online Access:https://www.mdpi.com/2073-4360/12/12/2996

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