Motor Neuron Gene Therapy: Lessons from Spinal Muscular Atrophy for Amyotrophic Lateral Sclerosis

Motor Neuron Gene Therapy: Lessons from Spinal Muscular Atrophy for Amyotrophic Lateral Sclerosis

Spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) are severe nervous system diseases characterized by the degeneration of lower motor neurons. They share a number of additional pathological, cellular, and genetic parallels suggesting that mechanistic and clinical insights into on...

書誌詳細
主要な著者:	Andrew P. Tosolini, James N. Sleigh
フォーマット:	論文
言語:	English
出版事項:	Frontiers Media S.A. 2017-12-01
シリーズ:	Frontiers in Molecular Neuroscience
主題:	adeno-associated virus (AAV) ALS antisense oligonucleotide (ASO) motor neuron disease (MND) neurodegeneration neurotrophic factor
オンライン･アクセス:	http://journal.frontiersin.org/article/10.3389/fnmol.2017.00405/full

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