Motor Neuron Gene Therapy: Lessons from Spinal Muscular Atrophy for Amyotrophic Lateral Sclerosis

Motor Neuron Gene Therapy: Lessons from Spinal Muscular Atrophy for Amyotrophic Lateral Sclerosis

Spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) are severe nervous system diseases characterized by the degeneration of lower motor neurons. They share a number of additional pathological, cellular, and genetic parallels suggesting that mechanistic and clinical insights into on...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Andrew P. Tosolini, James N. Sleigh
Format: Artykuł
Język:English
Wydane: Frontiers Media S.A. 2017-12-01
Seria:Frontiers in Molecular Neuroscience
Hasła przedmiotowe:
adeno-associated virus (AAV)
ALS
antisense oligonucleotide (ASO)
motor neuron disease (MND)
neurodegeneration
neurotrophic factor
Dostęp online:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00405/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00405/full

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