Impaired Barrier Function and Immunity in the Colon of Aldo-Keto Reductase 1B8 Deficient Mice

Impaired Barrier Function and Immunity in the Colon of Aldo-Keto Reductase 1B8 Deficient Mice

Aldo-keto reductase 1B10 (AKR1B10) is downregulated in human ulcerative colitis (UC) and colorectal cancer, being a potential pathogenic factor of these diseases. Aldo-keto reductase 1B8 (AKR1B8) is the ortholog in mice of human AKR1B10. Targeted AKR1B8 deficiency disrupts homeostasis of epithelial...

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Bibliographic Details
Main Authors: Xin Wang, Ramina Khoshaba, Yi Shen, Yu Cao, Minglin Lin, Yun Zhu, Zhe Cao, Duan-Fang Liao, Deliang Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
aldo-keto reductase 1B8
intestinal epithelial cells
intestinal immunity
cytokines
AKT and ERK signaling pathways
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.632805/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.632805/full

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