A proof of principle study using radiopharmaceuticals to quantify and localize container-content interactions in medical syringes
Abstract The sorption of drugs onto their contents is a known phenomenon that is difficult to analyse precisely. The purpose of this study was to present a non-invasive method for locating and quantifying sorption phenomena using radiopharmaceuticals. Radiopharmaceutical are medicines armed with a r...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-29923-z |
| _version_ | 1797865002862903296 |
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| author | C. Dupire P. Chennell B. Pereira N. Courtiol S. Buj R. Cueff S. Crauste-Manciet V. Sautou C. Morgat |
| author_facet | C. Dupire P. Chennell B. Pereira N. Courtiol S. Buj R. Cueff S. Crauste-Manciet V. Sautou C. Morgat |
| author_sort | C. Dupire |
| collection | DOAJ |
| description | Abstract The sorption of drugs onto their contents is a known phenomenon that is difficult to analyse precisely. The purpose of this study was to present a non-invasive method for locating and quantifying sorption phenomena using radiopharmaceuticals. Radiopharmaceutical are medicines armed with a radionuclide enabling quantification and imaging using dedicated scanners. The sorption of nine different radiopharmaceuticals on 2- and 3-part syringes was investigated. These syringes were filled with the studied radiopharmaceutical solutions and stored immobile for 3 h. At different times ranging from 0 to 180 min, 10 µL were taken from the syringes and the radioactivity of these samples was determined by a gamma counter. 5 radiopharmaceuticals exhibited no significant sorption at any time point in both 2 and 3-parts syringes, but 4 radiopharmaceuticals exhibited sorption losses varying from 20 to 33% after 3 h contact with 3-part-syringes, but no sorption on 2-part syringes at any time point. [99mTc]Tc-tetrofosmine Single Photon Emission Computed Tomography/Computed Tomography imaging indicated clearly that the interactions were located on the rubber plunger of the 3-part-syringes. The specific nature of radiopharmaceuticals allowed their use as an innovative method to quantify and localize drug sorption phenomena. |
| first_indexed | 2024-04-09T23:02:02Z |
| format | Article |
| id | doaj.art-b12d3cdfaa7247a6bc961423b24fdadc |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T23:02:02Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b12d3cdfaa7247a6bc961423b24fdadc2023-03-22T10:57:05ZengNature PortfolioScientific Reports2045-23222023-02-011311910.1038/s41598-023-29923-zA proof of principle study using radiopharmaceuticals to quantify and localize container-content interactions in medical syringesC. Dupire0P. Chennell1B. Pereira2N. Courtiol3S. Buj4R. Cueff5S. Crauste-Manciet6V. Sautou7C. Morgat8Pharmaceutical Technology Department, Bordeaux University HospitalUniversité Clermont Auvergne, CHU Clermont Ferrand, Clermont Auvergne INP, CNRS, ICCFDepartment of Clinical Research and Innovation, Clermont-Ferrand University HospitalPharmaceutical Technology Department, Bordeaux University HospitalNuclear Medicine Department, Bordeaux University HospitalUniversité Clermont Auvergne, Clermont Auvergne INP, CNRS, ICCFMINT Laboratory UMR INSERM 1066/CNRS 6021, IBS CHUUniversité Clermont Auvergne, CHU Clermont Ferrand, Clermont Auvergne INP, CNRS, ICCFNuclear Medicine Department, Bordeaux University HospitalAbstract The sorption of drugs onto their contents is a known phenomenon that is difficult to analyse precisely. The purpose of this study was to present a non-invasive method for locating and quantifying sorption phenomena using radiopharmaceuticals. Radiopharmaceutical are medicines armed with a radionuclide enabling quantification and imaging using dedicated scanners. The sorption of nine different radiopharmaceuticals on 2- and 3-part syringes was investigated. These syringes were filled with the studied radiopharmaceutical solutions and stored immobile for 3 h. At different times ranging from 0 to 180 min, 10 µL were taken from the syringes and the radioactivity of these samples was determined by a gamma counter. 5 radiopharmaceuticals exhibited no significant sorption at any time point in both 2 and 3-parts syringes, but 4 radiopharmaceuticals exhibited sorption losses varying from 20 to 33% after 3 h contact with 3-part-syringes, but no sorption on 2-part syringes at any time point. [99mTc]Tc-tetrofosmine Single Photon Emission Computed Tomography/Computed Tomography imaging indicated clearly that the interactions were located on the rubber plunger of the 3-part-syringes. The specific nature of radiopharmaceuticals allowed their use as an innovative method to quantify and localize drug sorption phenomena.https://doi.org/10.1038/s41598-023-29923-z |
| spellingShingle | C. Dupire P. Chennell B. Pereira N. Courtiol S. Buj R. Cueff S. Crauste-Manciet V. Sautou C. Morgat A proof of principle study using radiopharmaceuticals to quantify and localize container-content interactions in medical syringes Scientific Reports |
| title | A proof of principle study using radiopharmaceuticals to quantify and localize container-content interactions in medical syringes |
| title_full | A proof of principle study using radiopharmaceuticals to quantify and localize container-content interactions in medical syringes |
| title_fullStr | A proof of principle study using radiopharmaceuticals to quantify and localize container-content interactions in medical syringes |
| title_full_unstemmed | A proof of principle study using radiopharmaceuticals to quantify and localize container-content interactions in medical syringes |
| title_short | A proof of principle study using radiopharmaceuticals to quantify and localize container-content interactions in medical syringes |
| title_sort | proof of principle study using radiopharmaceuticals to quantify and localize container content interactions in medical syringes |
| url | https://doi.org/10.1038/s41598-023-29923-z |
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