Improved methods for fluorescence microscopy detection of macromolecules at the axon initial segment

Improved methods for fluorescence microscopy detection of macromolecules at the axon initial segment

The axonal initial segment (AIS) is the subcellular compartment required for initiation of the action potential in neurons. Scaffolding and regulatory proteins at the AIS cluster with ion channels ensuring the integrity of electrical signaling. Interference with the configuration of this protein net...

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Bibliographic Details
Main Authors: Musaad A Alshammari, Tahani K Alshammari, Fernanda eLaezza
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Immunohistochemistry
Sodium channel
axon initial segment
fixation
Nodes of Ranvier
FGF14
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00005/full

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