Efficiency of Platelet Transfusion in Patients with Moderate-to-Severe Chronic Kidney Disease and Thrombocytopenia
There have been relatively few studies revealing a decreased platelet count in chronic kidney disease (CKD). Although this hematological abnormality is not as well documented as renal anemia, platelet functions are altered in the uremic environment and there is an increased risk of bleeding. The aim...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-11-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/24/21/15895 |
_version_ | 1797631813835816960 |
---|---|
author | Sevigean Ali Mihaela Botnarciuc Lavinia Carmen Daba Sorina Ispas Alina Mihaela Stanigut Camelia Pana Marian-Catalin Burcila Liliana-Ana Tuta |
author_facet | Sevigean Ali Mihaela Botnarciuc Lavinia Carmen Daba Sorina Ispas Alina Mihaela Stanigut Camelia Pana Marian-Catalin Burcila Liliana-Ana Tuta |
author_sort | Sevigean Ali |
collection | DOAJ |
description | There have been relatively few studies revealing a decreased platelet count in chronic kidney disease (CKD). Although this hematological abnormality is not as well documented as renal anemia, platelet functions are altered in the uremic environment and there is an increased risk of bleeding. The aim of this study was to assess the effectiveness of the administration of platelet concentrate in CKD based on how patient prognosis was influenced by platelet transfusion therapy. The study monitored 104 patients with CKD and thrombocytopenia who received platelet transfusion during their hospitalization in the period from 2015 to 2021. The complete blood cell count, serum urea and creatinine, and inflammatory status were tested upon admission. The number of transfused platelet units were considered for each patient. A Kruskal–Wallis H test showed that for one transfused platelet unit, the distribution of the number of platelets (×10<sup>3</sup>/µL) was the same across the categories of associated diagnoses, which was seen as possible risk factors for thrombocytopenia, including liver cirrhosis and urosepsis. With a single exception, all patients exceeded the critical threshold of 20 × 10<sup>3</sup>/µL and 14 patients remained under 50 × 10<sup>3</sup>/µL. Even though our patients exceeded the critical threshold of platelet numbers, in patients with multiple comorbidities, severe, uncontrolled hemorrhages could not be prevented in 4.83% of cases. |
first_indexed | 2024-03-11T11:27:40Z |
format | Article |
id | doaj.art-b12f82c03d86464d972ab25da0ba919a |
institution | Directory Open Access Journal |
issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-11T11:27:40Z |
publishDate | 2023-11-01 |
publisher | MDPI AG |
record_format | Article |
series | International Journal of Molecular Sciences |
spelling | doaj.art-b12f82c03d86464d972ab25da0ba919a2023-11-10T15:05:42ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-11-0124211589510.3390/ijms242115895Efficiency of Platelet Transfusion in Patients with Moderate-to-Severe Chronic Kidney Disease and ThrombocytopeniaSevigean Ali0Mihaela Botnarciuc1Lavinia Carmen Daba2Sorina Ispas3Alina Mihaela Stanigut4Camelia Pana5Marian-Catalin Burcila6Liliana-Ana Tuta7Preclinical Disciplines Department, Faculty of Medicine, Campus B, Ovidius University of Constanta, Aleea Universitatii nr. 1, 900470 Constanta, RomaniaPreclinical Disciplines Department, Faculty of Medicine, Campus B, Ovidius University of Constanta, Aleea Universitatii nr. 1, 900470 Constanta, RomaniaPreclinical Disciplines Department, Faculty of Medicine, Campus B, Ovidius University of Constanta, Aleea Universitatii nr. 1, 900470 Constanta, RomaniaPreclinical Disciplines Department, Faculty of Medicine, Campus B, Ovidius University of Constanta, Aleea Universitatii nr. 1, 900470 Constanta, RomaniaClinical Medical Disciplines Department, Faculty of Medicine, Campus B, Ovidius University of Constanta, Aleea Universitatii nr. 1, 900470 Constanta, RomaniaClinical Medical Disciplines Department, Faculty of Medicine, Campus B, Ovidius University of Constanta, Aleea Universitatii nr. 1, 900470 Constanta, RomaniaClinical Medical Disciplines Department, Faculty of Medicine, Campus B, Ovidius University of Constanta, Aleea Universitatii nr. 1, 900470 Constanta, RomaniaClinical Medical Disciplines Department, Faculty of Medicine, Campus B, Ovidius University of Constanta, Aleea Universitatii nr. 1, 900470 Constanta, RomaniaThere have been relatively few studies revealing a decreased platelet count in chronic kidney disease (CKD). Although this hematological abnormality is not as well documented as renal anemia, platelet functions are altered in the uremic environment and there is an increased risk of bleeding. The aim of this study was to assess the effectiveness of the administration of platelet concentrate in CKD based on how patient prognosis was influenced by platelet transfusion therapy. The study monitored 104 patients with CKD and thrombocytopenia who received platelet transfusion during their hospitalization in the period from 2015 to 2021. The complete blood cell count, serum urea and creatinine, and inflammatory status were tested upon admission. The number of transfused platelet units were considered for each patient. A Kruskal–Wallis H test showed that for one transfused platelet unit, the distribution of the number of platelets (×10<sup>3</sup>/µL) was the same across the categories of associated diagnoses, which was seen as possible risk factors for thrombocytopenia, including liver cirrhosis and urosepsis. With a single exception, all patients exceeded the critical threshold of 20 × 10<sup>3</sup>/µL and 14 patients remained under 50 × 10<sup>3</sup>/µL. Even though our patients exceeded the critical threshold of platelet numbers, in patients with multiple comorbidities, severe, uncontrolled hemorrhages could not be prevented in 4.83% of cases.https://www.mdpi.com/1422-0067/24/21/15895plateletstransfusionchronic kidney diseaseuremic toxins |
spellingShingle | Sevigean Ali Mihaela Botnarciuc Lavinia Carmen Daba Sorina Ispas Alina Mihaela Stanigut Camelia Pana Marian-Catalin Burcila Liliana-Ana Tuta Efficiency of Platelet Transfusion in Patients with Moderate-to-Severe Chronic Kidney Disease and Thrombocytopenia International Journal of Molecular Sciences platelets transfusion chronic kidney disease uremic toxins |
title | Efficiency of Platelet Transfusion in Patients with Moderate-to-Severe Chronic Kidney Disease and Thrombocytopenia |
title_full | Efficiency of Platelet Transfusion in Patients with Moderate-to-Severe Chronic Kidney Disease and Thrombocytopenia |
title_fullStr | Efficiency of Platelet Transfusion in Patients with Moderate-to-Severe Chronic Kidney Disease and Thrombocytopenia |
title_full_unstemmed | Efficiency of Platelet Transfusion in Patients with Moderate-to-Severe Chronic Kidney Disease and Thrombocytopenia |
title_short | Efficiency of Platelet Transfusion in Patients with Moderate-to-Severe Chronic Kidney Disease and Thrombocytopenia |
title_sort | efficiency of platelet transfusion in patients with moderate to severe chronic kidney disease and thrombocytopenia |
topic | platelets transfusion chronic kidney disease uremic toxins |
url | https://www.mdpi.com/1422-0067/24/21/15895 |
work_keys_str_mv | AT sevigeanali efficiencyofplatelettransfusioninpatientswithmoderatetoseverechronickidneydiseaseandthrombocytopenia AT mihaelabotnarciuc efficiencyofplatelettransfusioninpatientswithmoderatetoseverechronickidneydiseaseandthrombocytopenia AT laviniacarmendaba efficiencyofplatelettransfusioninpatientswithmoderatetoseverechronickidneydiseaseandthrombocytopenia AT sorinaispas efficiencyofplatelettransfusioninpatientswithmoderatetoseverechronickidneydiseaseandthrombocytopenia AT alinamihaelastanigut efficiencyofplatelettransfusioninpatientswithmoderatetoseverechronickidneydiseaseandthrombocytopenia AT cameliapana efficiencyofplatelettransfusioninpatientswithmoderatetoseverechronickidneydiseaseandthrombocytopenia AT mariancatalinburcila efficiencyofplatelettransfusioninpatientswithmoderatetoseverechronickidneydiseaseandthrombocytopenia AT lilianaanatuta efficiencyofplatelettransfusioninpatientswithmoderatetoseverechronickidneydiseaseandthrombocytopenia |