Pharmacokinetic Variability of Amikacin After Once-Daily and Twice-Daily Dosing Regimen in Full-Term Neonates
The purpose of the study was to compare peak (Cpeak) and trough (Ctrough) amikacin levels after twice-daily (TD) or once-daily dosing (OD) in full-term neonates. Additionally, the study aimed to address amikacin pharmacokinetics and its variability. Data included 31 patients born on term. Amikacin d...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319301963 |
| _version_ | 1819112398604206080 |
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| author | Katarina Vučićević Zorica Rakonjac Branislava Miljković Borisav Janković Milica Prostran |
| author_facet | Katarina Vučićević Zorica Rakonjac Branislava Miljković Borisav Janković Milica Prostran |
| author_sort | Katarina Vučićević |
| collection | DOAJ |
| description | The purpose of the study was to compare peak (Cpeak) and trough (Ctrough) amikacin levels after twice-daily (TD) or once-daily dosing (OD) in full-term neonates. Additionally, the study aimed to address amikacin pharmacokinetics and its variability. Data included 31 patients born on term. Amikacin daily dose was 15 or 20 mg/kg depending on the neonate’s age. Patients randomly received amikacin every 12 or 24 h. In all patients corresponding Cpeak and Ctrough were taken. Volume of distribution (Vd), clearance (CL) and half-life (t1/2) were calculated. Mean Cpeak of 21.79 μg/ml in the TD group was statistically different from Cpeak of 36.39 μg/ml in the OD group. Average Ctrough in TD (5.67 μg/ml) was statistically different from the corresponding 3.99 μg/ml in the OD group. Mean amikacin Vd, CL, and t1/2 were 0.78 ± 0.38 l/kg, 86.99 ± 48.22 ml/h∙kg, and 6.81 ± 2.51 h, respectively. High interindividual pharmacokinetic variability was observed. Further analysis showed that neonatal age contributed to the pharmacokinetic parameters’ values. Statistically significant difference in CL and t1/2 was observed between patients age ≤ 2 and > 2 days on therapy initiation. As expected, amikacin given OD achieved higher Cpeak and lower Ctrough than TD. Based on the results, observed variability in amikacin pharmacokinetics was possibly due to the renal maturation process. Keywords:: amikacin, pharmacokinetics, full-term neonate, dosing regimen |
| first_indexed | 2024-12-22T04:12:53Z |
| format | Article |
| id | doaj.art-b130f2b365654f24b96b47943a6a62e1 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-22T04:12:53Z |
| publishDate | 2014-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-b130f2b365654f24b96b47943a6a62e12022-12-21T18:39:28ZengElsevierJournal of Pharmacological Sciences1347-86132014-01-011242138143Pharmacokinetic Variability of Amikacin After Once-Daily and Twice-Daily Dosing Regimen in Full-Term NeonatesKatarina Vučićević0Zorica Rakonjac1Branislava Miljković2Borisav Janković3Milica Prostran4Department of Pharmacokinetics and Clinical Pharmacy, University of Belgrade-Faculty of Pharmacy, 11000 Belgrade, Serbia; Corresponding author. kacav@pharmacy.bg.ac.rsInstitute for Mother and Child Care of Serbia “Dr. Vukan Čupić”, 11000 Belgrade, SerbiaDepartment of Pharmacokinetics and Clinical Pharmacy, University of Belgrade-Faculty of Pharmacy, 11000 Belgrade, SerbiaInstitute for Mother and Child Care of Serbia “Dr. Vukan Čupić”, 11000 Belgrade, Serbia; Department of Pediatrics, University of Belgrade-School of Medicine, 11000 Belgrade, SerbiaDepartment of Pharmacology, Clinical Pharmacology and Toxicology, University of Belgrade-School of Medicine, 11000 Belgrade, SerbiaThe purpose of the study was to compare peak (Cpeak) and trough (Ctrough) amikacin levels after twice-daily (TD) or once-daily dosing (OD) in full-term neonates. Additionally, the study aimed to address amikacin pharmacokinetics and its variability. Data included 31 patients born on term. Amikacin daily dose was 15 or 20 mg/kg depending on the neonate’s age. Patients randomly received amikacin every 12 or 24 h. In all patients corresponding Cpeak and Ctrough were taken. Volume of distribution (Vd), clearance (CL) and half-life (t1/2) were calculated. Mean Cpeak of 21.79 μg/ml in the TD group was statistically different from Cpeak of 36.39 μg/ml in the OD group. Average Ctrough in TD (5.67 μg/ml) was statistically different from the corresponding 3.99 μg/ml in the OD group. Mean amikacin Vd, CL, and t1/2 were 0.78 ± 0.38 l/kg, 86.99 ± 48.22 ml/h∙kg, and 6.81 ± 2.51 h, respectively. High interindividual pharmacokinetic variability was observed. Further analysis showed that neonatal age contributed to the pharmacokinetic parameters’ values. Statistically significant difference in CL and t1/2 was observed between patients age ≤ 2 and > 2 days on therapy initiation. As expected, amikacin given OD achieved higher Cpeak and lower Ctrough than TD. Based on the results, observed variability in amikacin pharmacokinetics was possibly due to the renal maturation process. Keywords:: amikacin, pharmacokinetics, full-term neonate, dosing regimenhttp://www.sciencedirect.com/science/article/pii/S1347861319301963 |
| spellingShingle | Katarina Vučićević Zorica Rakonjac Branislava Miljković Borisav Janković Milica Prostran Pharmacokinetic Variability of Amikacin After Once-Daily and Twice-Daily Dosing Regimen in Full-Term Neonates Journal of Pharmacological Sciences |
| title | Pharmacokinetic Variability of Amikacin After Once-Daily and Twice-Daily Dosing Regimen in Full-Term Neonates |
| title_full | Pharmacokinetic Variability of Amikacin After Once-Daily and Twice-Daily Dosing Regimen in Full-Term Neonates |
| title_fullStr | Pharmacokinetic Variability of Amikacin After Once-Daily and Twice-Daily Dosing Regimen in Full-Term Neonates |
| title_full_unstemmed | Pharmacokinetic Variability of Amikacin After Once-Daily and Twice-Daily Dosing Regimen in Full-Term Neonates |
| title_short | Pharmacokinetic Variability of Amikacin After Once-Daily and Twice-Daily Dosing Regimen in Full-Term Neonates |
| title_sort | pharmacokinetic variability of amikacin after once daily and twice daily dosing regimen in full term neonates |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319301963 |
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