An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans.
To examine the association between the 5-HTTLPR polymorphism of the serotonin transporter (SLC6A4) gene, combat exposure, and posttraumatic stress disorder (PTSD) diagnosis and among two samples of combat-exposed veterans.The first sample included 550 non-Hispanic Black (NHB) combat-exposed veterans...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4368771?pdf=render |
| _version_ | 1818290047810535424 |
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| author | Yutao Liu Melanie E Garrett Michelle F Dennis Kimberly T Green VA Mid-Atlantic MIRECC Registry Workgroup Allison E Ashley-Koch Michael A Hauser Jean C Beckham Nathan A Kimbrel |
| author_facet | Yutao Liu Melanie E Garrett Michelle F Dennis Kimberly T Green VA Mid-Atlantic MIRECC Registry Workgroup Allison E Ashley-Koch Michael A Hauser Jean C Beckham Nathan A Kimbrel |
| author_sort | Yutao Liu |
| collection | DOAJ |
| description | To examine the association between the 5-HTTLPR polymorphism of the serotonin transporter (SLC6A4) gene, combat exposure, and posttraumatic stress disorder (PTSD) diagnosis and among two samples of combat-exposed veterans.The first sample included 550 non-Hispanic Black (NHB) combat-exposed veterans. The second sample included 555 non-Hispanic White (NHW) combat-exposed veterans. Participants were genotyped for the 5-HTTLPR/rs25531 variants of the SLC6A4 gene. A structured clinical interview was used to diagnose PTSD. Combat and civilian trauma exposure were assessed with validated self-report instruments. Logistic regression was used to test for main effects of 5-HTTLPR on PTSD diagnosis as well as gene x environment (GxE) interactions after adjusting for sex, ancestry proportion scores, civilian trauma exposure, and combat exposure.Within the NHB sample, a significant additive effect was observed for 5-HTTLPR (OR = 1.502, p = .0025), such that the odds of having a current diagnosis of PTSD increased by 1.502 for each additional S' allele. No evidence for an association between 5-HTTLPR and PTSD was observed in the NHW sample. In addition, no evidence for combat x 5-HTTLPR effects were observed in either sample.The present study suggests that there may be an association between 5-HTTLPR genotype and PTSD diagnosis among NHB veterans; however, no evidence for the hypothesized 5-HTTLPR x combat interaction was found. |
| first_indexed | 2024-12-13T02:21:58Z |
| format | Article |
| id | doaj.art-b131ec5cd3fb43dc89f489030b33a28b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T02:21:58Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b131ec5cd3fb43dc89f489030b33a28b2022-12-22T00:02:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e011999810.1371/journal.pone.0119998An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans.Yutao LiuMelanie E GarrettMichelle F DennisKimberly T GreenVA Mid-Atlantic MIRECC Registry WorkgroupAllison E Ashley-KochMichael A HauserJean C BeckhamNathan A KimbrelTo examine the association between the 5-HTTLPR polymorphism of the serotonin transporter (SLC6A4) gene, combat exposure, and posttraumatic stress disorder (PTSD) diagnosis and among two samples of combat-exposed veterans.The first sample included 550 non-Hispanic Black (NHB) combat-exposed veterans. The second sample included 555 non-Hispanic White (NHW) combat-exposed veterans. Participants were genotyped for the 5-HTTLPR/rs25531 variants of the SLC6A4 gene. A structured clinical interview was used to diagnose PTSD. Combat and civilian trauma exposure were assessed with validated self-report instruments. Logistic regression was used to test for main effects of 5-HTTLPR on PTSD diagnosis as well as gene x environment (GxE) interactions after adjusting for sex, ancestry proportion scores, civilian trauma exposure, and combat exposure.Within the NHB sample, a significant additive effect was observed for 5-HTTLPR (OR = 1.502, p = .0025), such that the odds of having a current diagnosis of PTSD increased by 1.502 for each additional S' allele. No evidence for an association between 5-HTTLPR and PTSD was observed in the NHW sample. In addition, no evidence for combat x 5-HTTLPR effects were observed in either sample.The present study suggests that there may be an association between 5-HTTLPR genotype and PTSD diagnosis among NHB veterans; however, no evidence for the hypothesized 5-HTTLPR x combat interaction was found.http://europepmc.org/articles/PMC4368771?pdf=render |
| spellingShingle | Yutao Liu Melanie E Garrett Michelle F Dennis Kimberly T Green VA Mid-Atlantic MIRECC Registry Workgroup Allison E Ashley-Koch Michael A Hauser Jean C Beckham Nathan A Kimbrel An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans. PLoS ONE |
| title | An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans. |
| title_full | An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans. |
| title_fullStr | An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans. |
| title_full_unstemmed | An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans. |
| title_short | An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans. |
| title_sort | examination of the association between 5 httlpr combat exposure and ptsd diagnosis among u s veterans |
| url | http://europepmc.org/articles/PMC4368771?pdf=render |
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