Transmission-selective muscle pathology induced by the active propagation of mutant huntingtin across the human neuromuscular synapse

Transmission-selective muscle pathology induced by the active propagation of mutant huntingtin across the human neuromuscular synapse

Neuron-to-neuron transmission of aggregation-prone, misfolded proteins may potentially explain the spatiotemporal accumulation of pathological lesions in the brains of patients with neurodegenerative protein-misfolding diseases (PMDs). However, little is known about protein transmission from the cen...

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Bibliographic Details
Main Authors: Margarita C. Dinamarca, Laura Colombo, Urszula Brykczynska, Amandine Grimm, Isabelle Fruh, Imtiaz Hossain, Daniela Gabriel, Anne Eckert, Matthias Müller, Eline Pecho-Vrieseling
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
hiPSC
neuromuscular system
synaptic
protein transmission
neurodegeneration
mutant huntingtin
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1287510/full

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