Prognostic significance of tumor markers in T4a gastric cancer
<p>Abstract</p> <p>Background</p> <p>The clinical importance of preoperative tumor markers remain elusive in gastric cancer. The aim of this study was to evaluate the prognostic value of AFP, CEA, CA19-9, and CA50 in T4a stage gastric cancer.</p> <p>Methods&...
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| Format: | Article |
| Language: | English |
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BMC
2012-04-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://www.wjso.com/content/10/1/68 |
| _version_ | 1828358972246065152 |
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| author | Liu Xiaowen Cai Hong Wang Yanong |
| author_facet | Liu Xiaowen Cai Hong Wang Yanong |
| author_sort | Liu Xiaowen |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The clinical importance of preoperative tumor markers remain elusive in gastric cancer. The aim of this study was to evaluate the prognostic value of AFP, CEA, CA19-9, and CA50 in T4a stage gastric cancer.</p> <p>Methods</p> <p>Two hundred and seventy-three T4a gastric cancer patients who underwent curative D2 gastrectomy between 1996 and 2005 were evaluated. The correlation between tumor markers and clinicopathologic characteristics and prognostic value of preoperative tumor markers were investigated.</p> <p>Results</p> <p>Correlation analysis showed that AFP was associated with Borrmann type (<it>P</it> = 0.010); CEA with sex (<it>P</it> = 0.029), tumors site (<it>P</it> = 0.014), and N stage (<it>P</it> = 0.001); CA19-9 with age (<it>P</it> = 0.047), tumor site (<it>P</it> = 0.011), lymphovascular invasion (<it>P</it> = 0.004), and N stage (<it>P</it> = 0.000); CA50 with age (<it>P</it> = 0.017), tumor site (<it>P</it> = 0.004), tumor size (<it>P</it> = 0.014), and N stage (<it>P</it> = 0.000). Multivariate analysis showed that the positivity of preoperative CEA, CA19-9, and CA50 were major independent poor prognostic factors of patients with T4a stage gastric cancer.</p> <p>Conclusions</p> <p>Preoperative serum tumor marker might be a candidate for the staging system in addition to conventional factors.</p> |
| first_indexed | 2024-04-14T03:36:10Z |
| format | Article |
| id | doaj.art-b134522d25324a3baac30ffaaa5c25b1 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-14T03:36:10Z |
| publishDate | 2012-04-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-b134522d25324a3baac30ffaaa5c25b12022-12-22T02:14:46ZengBMCWorld Journal of Surgical Oncology1477-78192012-04-011016810.1186/1477-7819-10-68Prognostic significance of tumor markers in T4a gastric cancerLiu XiaowenCai HongWang Yanong<p>Abstract</p> <p>Background</p> <p>The clinical importance of preoperative tumor markers remain elusive in gastric cancer. The aim of this study was to evaluate the prognostic value of AFP, CEA, CA19-9, and CA50 in T4a stage gastric cancer.</p> <p>Methods</p> <p>Two hundred and seventy-three T4a gastric cancer patients who underwent curative D2 gastrectomy between 1996 and 2005 were evaluated. The correlation between tumor markers and clinicopathologic characteristics and prognostic value of preoperative tumor markers were investigated.</p> <p>Results</p> <p>Correlation analysis showed that AFP was associated with Borrmann type (<it>P</it> = 0.010); CEA with sex (<it>P</it> = 0.029), tumors site (<it>P</it> = 0.014), and N stage (<it>P</it> = 0.001); CA19-9 with age (<it>P</it> = 0.047), tumor site (<it>P</it> = 0.011), lymphovascular invasion (<it>P</it> = 0.004), and N stage (<it>P</it> = 0.000); CA50 with age (<it>P</it> = 0.017), tumor site (<it>P</it> = 0.004), tumor size (<it>P</it> = 0.014), and N stage (<it>P</it> = 0.000). Multivariate analysis showed that the positivity of preoperative CEA, CA19-9, and CA50 were major independent poor prognostic factors of patients with T4a stage gastric cancer.</p> <p>Conclusions</p> <p>Preoperative serum tumor marker might be a candidate for the staging system in addition to conventional factors.</p>http://www.wjso.com/content/10/1/68Tumor markersGastric cancerPrognosis |
| spellingShingle | Liu Xiaowen Cai Hong Wang Yanong Prognostic significance of tumor markers in T4a gastric cancer World Journal of Surgical Oncology Tumor markers Gastric cancer Prognosis |
| title | Prognostic significance of tumor markers in T4a gastric cancer |
| title_full | Prognostic significance of tumor markers in T4a gastric cancer |
| title_fullStr | Prognostic significance of tumor markers in T4a gastric cancer |
| title_full_unstemmed | Prognostic significance of tumor markers in T4a gastric cancer |
| title_short | Prognostic significance of tumor markers in T4a gastric cancer |
| title_sort | prognostic significance of tumor markers in t4a gastric cancer |
| topic | Tumor markers Gastric cancer Prognosis |
| url | http://www.wjso.com/content/10/1/68 |
| work_keys_str_mv | AT liuxiaowen prognosticsignificanceoftumormarkersint4agastriccancer AT caihong prognosticsignificanceoftumormarkersint4agastriccancer AT wangyanong prognosticsignificanceoftumormarkersint4agastriccancer |