Evolutionary engineering and characterization of Sendai virus mutants capable of persistent infection and autonomous production

Evolutionary engineering and characterization of Sendai virus mutants capable of persistent infection and autonomous production

Persistent virus infection involves modifying the host immune response and maintaining viral infection. Acute infection with Mononegavirales, such as Sendai viruses (SeVs), can give rise to viruses capable of persistent infection. SeVs establish persistent infection through generating copyback-type...

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Bibliographic Details
Main Authors: Moe Iwata, Ryoko Kawabata, Nao Morimoto, Ryosuke F. Takeuchi, Takemasa Sakaguchi, Takashi Irie, Fumitaka Osakada
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Virology
Subjects:
Sendai virus
persistent infection
defective interfering genome
temperature sensitive mutation
Mononegavirales
viral vector
Online Access:https://www.frontiersin.org/articles/10.3389/fviro.2024.1363092/full

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