Nanotechnology: an effective tool for enhancing bioavailability and bioactivity of phytomedicine
To achieve the desired therapeutic objective, the drug product must deliver the active drug at an optimal rate and amount. By proper biopharmaceutic design, the rate and extent of drug absorption (also called as bioavailability) or the systemic delivery of drugs to the body can be varied from rapid...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-05-01
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| Series: | Asian Pacific Journal of Tropical Biomedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2221169115302306 |
| _version_ | 1818198179470901248 |
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| author | Thirumurugan Gunasekaran Tedesse Haile Tedele Nigusse Magharla Dasaratha Dhanaraju |
| author_facet | Thirumurugan Gunasekaran Tedesse Haile Tedele Nigusse Magharla Dasaratha Dhanaraju |
| author_sort | Thirumurugan Gunasekaran |
| collection | DOAJ |
| description | To achieve the desired therapeutic objective, the drug product must deliver the active drug at an optimal rate and amount. By proper biopharmaceutic design, the rate and extent of drug absorption (also called as bioavailability) or the systemic delivery of drugs to the body can be varied from rapid and complete absorption to slow and sustained absorption depending upon the desired therapeutic objective. Phytomedicine have served as the foundation for a larger fraction of the current pharmacopeia. But the delivery of phytomedicine is always problematic due to poor aqueous solubility, poor permeation, low systemic availability, instability and extensive first pass metabolism. Current review will discuss in detail about how nanotechnology can enhance the bioavilability and bioactivity of the phytomedicine. |
| first_indexed | 2024-12-12T02:01:45Z |
| format | Article |
| id | doaj.art-b136077891004deb8ff48f508bf2333e |
| institution | Directory Open Access Journal |
| issn | 2221-1691 |
| language | English |
| last_indexed | 2024-12-12T02:01:45Z |
| publishDate | 2014-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Biomedicine |
| spelling | doaj.art-b136077891004deb8ff48f508bf2333e2022-12-22T00:42:08ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912014-05-014S1S1S710.12980/APJTB.4.2014C980Nanotechnology: an effective tool for enhancing bioavailability and bioactivity of phytomedicineThirumurugan Gunasekaran0Tedesse Haile1Tedele Nigusse2Magharla Dasaratha Dhanaraju3Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, EthiopiaDepartment of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, EthiopiaDepartment of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, EthiopiaResearch Lab, GIET School of Pharmacy, NH-5, Chaitanya Nagar, Rajahmundry-533294, IndiaTo achieve the desired therapeutic objective, the drug product must deliver the active drug at an optimal rate and amount. By proper biopharmaceutic design, the rate and extent of drug absorption (also called as bioavailability) or the systemic delivery of drugs to the body can be varied from rapid and complete absorption to slow and sustained absorption depending upon the desired therapeutic objective. Phytomedicine have served as the foundation for a larger fraction of the current pharmacopeia. But the delivery of phytomedicine is always problematic due to poor aqueous solubility, poor permeation, low systemic availability, instability and extensive first pass metabolism. Current review will discuss in detail about how nanotechnology can enhance the bioavilability and bioactivity of the phytomedicine.http://www.sciencedirect.com/science/article/pii/S2221169115302306BioavailabilityBioactivityNanotechnologyPhytomedicine |
| spellingShingle | Thirumurugan Gunasekaran Tedesse Haile Tedele Nigusse Magharla Dasaratha Dhanaraju Nanotechnology: an effective tool for enhancing bioavailability and bioactivity of phytomedicine Asian Pacific Journal of Tropical Biomedicine Bioavailability Bioactivity Nanotechnology Phytomedicine |
| title | Nanotechnology: an effective tool for enhancing bioavailability and bioactivity of phytomedicine |
| title_full | Nanotechnology: an effective tool for enhancing bioavailability and bioactivity of phytomedicine |
| title_fullStr | Nanotechnology: an effective tool for enhancing bioavailability and bioactivity of phytomedicine |
| title_full_unstemmed | Nanotechnology: an effective tool for enhancing bioavailability and bioactivity of phytomedicine |
| title_short | Nanotechnology: an effective tool for enhancing bioavailability and bioactivity of phytomedicine |
| title_sort | nanotechnology an effective tool for enhancing bioavailability and bioactivity of phytomedicine |
| topic | Bioavailability Bioactivity Nanotechnology Phytomedicine |
| url | http://www.sciencedirect.com/science/article/pii/S2221169115302306 |
| work_keys_str_mv | AT thirumurugangunasekaran nanotechnologyaneffectivetoolforenhancingbioavailabilityandbioactivityofphytomedicine AT tedessehaile nanotechnologyaneffectivetoolforenhancingbioavailabilityandbioactivityofphytomedicine AT tedelenigusse nanotechnologyaneffectivetoolforenhancingbioavailabilityandbioactivityofphytomedicine AT magharladasarathadhanaraju nanotechnologyaneffectivetoolforenhancingbioavailabilityandbioactivityofphytomedicine |