Prevalence of Retinal Vein Occlusions and Estimated Cerebrospinal Fluid Pressure: The Kailuan Eye Study

Qian Wang,1,* Jingyan Yang,1,* Jost B Jonas,2 Xuehui Shi,1 Shouling Wu,3 Shuohua Chen,4 Yanni Yan,1 Wenjia Zhou,1 Li Dong,1 Wenbin Wei,1 Ya Xing Wang5 1Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key...

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Main Authors: Wang Q, Yang J, Jonas JB, Shi X, Wu S, Chen S, Yan Y, Zhou W, Dong L, Wei W, Wang YX
Format: Article
Language:English
Published: Dove Medical Press 2021-05-01
Series:Eye and Brain
Subjects:
Online Access:https://www.dovepress.com/prevalence-of-retinal-vein-occlusions-and-estimated-cerebrospinal-flui-peer-reviewed-fulltext-article-EB
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author Wang Q
Yang J
Jonas JB
Shi X
Wu S
Chen S
Yan Y
Zhou W
Dong L
Wei W
Wang YX
author_facet Wang Q
Yang J
Jonas JB
Shi X
Wu S
Chen S
Yan Y
Zhou W
Dong L
Wei W
Wang YX
author_sort Wang Q
collection DOAJ
description Qian Wang,1,* Jingyan Yang,1,* Jost B Jonas,2 Xuehui Shi,1 Shouling Wu,3 Shuohua Chen,4 Yanni Yan,1 Wenjia Zhou,1 Li Dong,1 Wenbin Wei,1 Ya Xing Wang5 1Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karis-University, Mannheim, Germany; 3Cardiology Department, Kailuan General Hospital, Tangshan, People’s Republic of China; 4Health Care Center, Kailuan Group, Tangshan, People’s Republic of China; 5Beijing Institute of Ophthalmology and Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenbin WeiBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Dong Cheng District, Beijing, 100730, People’s Republic of ChinaTel +86-10-58269516Fax +86-10-6512 5617Email weiwenbintr@163.comPurpose: To investigate the prevalence of retinal vein occlusions (RVOs) and associated factors in a Chinese population.Patients and Methods: The cross-sectional community-based Kailuan Eye Study included individuals who participated in the Kailuan Study. RVOs were diagnosed on the fundus photographs. Estimated cerebrospinal fluid pressure (eCSFP) was calculated as “eCSFP=0.44*Body Mass Index+0.16*Diastolic Blood Pressure-0.18*Age”.Results: The study included 12,499 participants with a mean age of 52.9± 13.1 years. The overall prevalence of RVO was 120/12,499 or 0.96%, with branch RVOs observed in 116/12,499 individuals and central RVOs in 4/12,499 individuals. RVOs started at the optic disc in 19 participants (15.8% of all RVOs), and in 101 (84.2%) individuals arterio-venous crossings outside the optic disc. In multivariable analysis, a higher RVO prevalence was associated with older age (P< 0.001), higher eCSFP (P< 0.001), and higher fasting serum glucose concentration (P< 0.001). Differentiating between RVOs at arterio-venous crossings and RVOs at the optic disc revealed that the prevalence of both RVO types was associated with higher eCSFP (P< 0.001 and P=0.004, respectively) after adjusting for age and fasting serum glucose concentration.Conclusion: In this adult Chinese population recruited on a community basis, the prevalence of any RVO (mean: 0.96) was associated with older age, higher eCSFP and higher fasting serum glucose concentration. Higher eCSFP may play an etiologic role in RVOs.Keywords: retinal vein occlusion, blood pressure, arterial hypertension, glaucoma, intraocular pressure, cerebrospinal fluid pressure
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spelling doaj.art-b13636256d1948668f22b59d0f34d8dc2022-12-21T18:43:53ZengDove Medical PressEye and Brain1179-27442021-05-01Volume 1314715665013Prevalence of Retinal Vein Occlusions and Estimated Cerebrospinal Fluid Pressure: The Kailuan Eye StudyWang QYang JJonas JBShi XWu SChen SYan YZhou WDong LWei WWang YXQian Wang,1,* Jingyan Yang,1,* Jost B Jonas,2 Xuehui Shi,1 Shouling Wu,3 Shuohua Chen,4 Yanni Yan,1 Wenjia Zhou,1 Li Dong,1 Wenbin Wei,1 Ya Xing Wang5 1Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karis-University, Mannheim, Germany; 3Cardiology Department, Kailuan General Hospital, Tangshan, People’s Republic of China; 4Health Care Center, Kailuan Group, Tangshan, People’s Republic of China; 5Beijing Institute of Ophthalmology and Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenbin WeiBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Dong Cheng District, Beijing, 100730, People’s Republic of ChinaTel +86-10-58269516Fax +86-10-6512 5617Email weiwenbintr@163.comPurpose: To investigate the prevalence of retinal vein occlusions (RVOs) and associated factors in a Chinese population.Patients and Methods: The cross-sectional community-based Kailuan Eye Study included individuals who participated in the Kailuan Study. RVOs were diagnosed on the fundus photographs. Estimated cerebrospinal fluid pressure (eCSFP) was calculated as “eCSFP=0.44*Body Mass Index+0.16*Diastolic Blood Pressure-0.18*Age”.Results: The study included 12,499 participants with a mean age of 52.9± 13.1 years. The overall prevalence of RVO was 120/12,499 or 0.96%, with branch RVOs observed in 116/12,499 individuals and central RVOs in 4/12,499 individuals. RVOs started at the optic disc in 19 participants (15.8% of all RVOs), and in 101 (84.2%) individuals arterio-venous crossings outside the optic disc. In multivariable analysis, a higher RVO prevalence was associated with older age (P< 0.001), higher eCSFP (P< 0.001), and higher fasting serum glucose concentration (P< 0.001). Differentiating between RVOs at arterio-venous crossings and RVOs at the optic disc revealed that the prevalence of both RVO types was associated with higher eCSFP (P< 0.001 and P=0.004, respectively) after adjusting for age and fasting serum glucose concentration.Conclusion: In this adult Chinese population recruited on a community basis, the prevalence of any RVO (mean: 0.96) was associated with older age, higher eCSFP and higher fasting serum glucose concentration. Higher eCSFP may play an etiologic role in RVOs.Keywords: retinal vein occlusion, blood pressure, arterial hypertension, glaucoma, intraocular pressure, cerebrospinal fluid pressurehttps://www.dovepress.com/prevalence-of-retinal-vein-occlusions-and-estimated-cerebrospinal-flui-peer-reviewed-fulltext-article-EBretinal vein occlusionblood pressurearterial hypertensionglaucomaintraocular pressurecerebrospinal fluid pressure
spellingShingle Wang Q
Yang J
Jonas JB
Shi X
Wu S
Chen S
Yan Y
Zhou W
Dong L
Wei W
Wang YX
Prevalence of Retinal Vein Occlusions and Estimated Cerebrospinal Fluid Pressure: The Kailuan Eye Study
Eye and Brain
retinal vein occlusion
blood pressure
arterial hypertension
glaucoma
intraocular pressure
cerebrospinal fluid pressure
title Prevalence of Retinal Vein Occlusions and Estimated Cerebrospinal Fluid Pressure: The Kailuan Eye Study
title_full Prevalence of Retinal Vein Occlusions and Estimated Cerebrospinal Fluid Pressure: The Kailuan Eye Study
title_fullStr Prevalence of Retinal Vein Occlusions and Estimated Cerebrospinal Fluid Pressure: The Kailuan Eye Study
title_full_unstemmed Prevalence of Retinal Vein Occlusions and Estimated Cerebrospinal Fluid Pressure: The Kailuan Eye Study
title_short Prevalence of Retinal Vein Occlusions and Estimated Cerebrospinal Fluid Pressure: The Kailuan Eye Study
title_sort prevalence of retinal vein occlusions and estimated cerebrospinal fluid pressure the kailuan eye study
topic retinal vein occlusion
blood pressure
arterial hypertension
glaucoma
intraocular pressure
cerebrospinal fluid pressure
url https://www.dovepress.com/prevalence-of-retinal-vein-occlusions-and-estimated-cerebrospinal-flui-peer-reviewed-fulltext-article-EB
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