Nitric Oxide Synthase Type 1 Methylation Is Associated With White Matter Microstructure in the Corpus Callosum and Greater Panic Disorder Severity Among Panic Disorder Patients

Nitric Oxide Synthase Type 1 Methylation Is Associated With White Matter Microstructure in the Corpus Callosum and Greater Panic Disorder Severity Among Panic Disorder Patients

Objectives: Methylation of the neuronal nitric oxide synthase (NOS1/nNOS) gene has recently been identified as a promising biomarker of psychiatric disorders. NOS1 plays an essential role in neurite outgrowth and may thus affect the microstructure development of white matter (WM) in the corpus callo...

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Bibliographic Details
Main Authors: Huazhen Xu, Yuan Zhong, Shiting Yuan, Yun Wu, Zijuan Ma, Ziyu Hao, Huachen Ding, Huiqing Wu, Gang Liu, Manlong Pang, Na Liu, Chun Wang, Ning Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Neurology
Subjects:
panic disorder (PD)
nitric oxide synthase type I
corpus callosum (CC)
DNA methylation
diffusion tensor imaging
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.755270/full

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