The effect of amixin and agmatine on cytochrome c release from isolated mitochondria
Mitochondrial nicotinic acetylcholine receptors (nAChRs) control permeability transition pore formation and cytochrome c release in the presence of apoptogenic factors. This study demonstrates that pharmacological agents amixin and agmatine affect mitochondrial nAChR functioning: they slightly suppr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2017-02-01
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| Series: | The Ukrainian Biochemical Journal |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2016/03/Uspenska_1_16.pdf |
| _version_ | 1797668856182865920 |
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| author | K. R. Uspenska G. L. Gergalova O. Yu. Lykhmus M. V. Skok |
| author_facet | K. R. Uspenska G. L. Gergalova O. Yu. Lykhmus M. V. Skok |
| author_sort | K. R. Uspenska |
| collection | DOAJ |
| description | Mitochondrial nicotinic acetylcholine receptors (nAChRs) control permeability transition pore formation and cytochrome c release in the presence of apoptogenic factors. This study demonstrates that pharmacological agents amixin and agmatine affect mitochondrial nAChR functioning: they slightly suppress cytochrome c release from mouse brain and liver mitochondria stimulated with apoptogenic dose of Са2+ and prevent the effect of α7 nAChR agonist PNU282987. We conclude that mitochondria may be one of therapeutic targets of amixin and agmatine. |
| first_indexed | 2024-03-11T20:34:34Z |
| format | Article |
| id | doaj.art-b1377d47e83b469ba2304b8146cb3f00 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-11T20:34:34Z |
| publishDate | 2017-02-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-b1377d47e83b469ba2304b8146cb3f002023-10-02T07:19:12ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032017-02-0188151010.15407/ubj88.01.005The effect of amixin and agmatine on cytochrome c release from isolated mitochondriaK. R. Uspenska0G. L. Gergalova1O. Yu. Lykhmus2M. V. Skok3Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, KyivPalladin Institute of Biochemistry, National Academy of Sciences of Ukraine, KyivPalladin Institute of Biochemistry, National Academy of Sciences of Ukraine, KyivPalladin Institute of Biochemistry, National Academy of Sciences of Ukraine, KyivMitochondrial nicotinic acetylcholine receptors (nAChRs) control permeability transition pore formation and cytochrome c release in the presence of apoptogenic factors. This study demonstrates that pharmacological agents amixin and agmatine affect mitochondrial nAChR functioning: they slightly suppress cytochrome c release from mouse brain and liver mitochondria stimulated with apoptogenic dose of Са2+ and prevent the effect of α7 nAChR agonist PNU282987. We conclude that mitochondria may be one of therapeutic targets of amixin and agmatine.http://ukrbiochemjournal.org/wp-content/uploads/2016/03/Uspenska_1_16.pdf |
| spellingShingle | K. R. Uspenska G. L. Gergalova O. Yu. Lykhmus M. V. Skok The effect of amixin and agmatine on cytochrome c release from isolated mitochondria The Ukrainian Biochemical Journal |
| title | The effect of amixin and agmatine on cytochrome c release from isolated mitochondria |
| title_full | The effect of amixin and agmatine on cytochrome c release from isolated mitochondria |
| title_fullStr | The effect of amixin and agmatine on cytochrome c release from isolated mitochondria |
| title_full_unstemmed | The effect of amixin and agmatine on cytochrome c release from isolated mitochondria |
| title_short | The effect of amixin and agmatine on cytochrome c release from isolated mitochondria |
| title_sort | effect of amixin and agmatine on cytochrome c release from isolated mitochondria |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2016/03/Uspenska_1_16.pdf |
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