African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations
While recent advances in genetics make it possible to follow the genetic exchanges between populations and their phenotypic consequences, the impact of the genetic exchanges on the sensory perception of populations has yet to be explored. From this perspective, the present study investigated the con...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/11/1405 |
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| author | Harilanto Razafindrazaka Veronica Pereda-Loth Camille Ferdenzi Margit Heiske Omar Alva Minah Randriamialisoa Caroline Costedoat Michel Signoli Thierry Talou Monique Courtade-Saidi Anne Boland Jean-François Deleuze Catherine Rouby Chantal Radimilahy Thierry Letellier Moustafa Bensafi Denis Pierron |
| author_facet | Harilanto Razafindrazaka Veronica Pereda-Loth Camille Ferdenzi Margit Heiske Omar Alva Minah Randriamialisoa Caroline Costedoat Michel Signoli Thierry Talou Monique Courtade-Saidi Anne Boland Jean-François Deleuze Catherine Rouby Chantal Radimilahy Thierry Letellier Moustafa Bensafi Denis Pierron |
| author_sort | Harilanto Razafindrazaka |
| collection | DOAJ |
| description | While recent advances in genetics make it possible to follow the genetic exchanges between populations and their phenotypic consequences, the impact of the genetic exchanges on the sensory perception of populations has yet to be explored. From this perspective, the present study investigated the consequences of African gene flow on odor perception in a Malagasy population with a predominantly East Asian genetic background. To this end, we combined psychophysical tests with genotype data of 235 individuals who were asked to smell the odorant molecule beta-ionone (βI). Results showed that in this population the ancestry of the OR5A1 gene significantly influences the ability to detect βI. At the individual level, African ancestry significantly protects against specific anosmia/hyposmia due to the higher frequency of the functional gene (OR ratios = 14, CI: 1.8–110, <i>p</i>-value = 0.012). At the population level, African introgression decreased the prevalence of specific anosmia/hyposmia to this odorous compound. Taken together, these findings validate the conjecture that in addition to cultural exchanges, genetic transfer may also influence the sensory perception of the population in contact. |
| first_indexed | 2024-03-10T05:39:35Z |
| format | Article |
| id | doaj.art-b13ca22dfc514911bb12a5b4e7c89aa8 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T05:39:35Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-b13ca22dfc514911bb12a5b4e7c89aa82023-11-22T22:37:11ZengMDPI AGBrain Sciences2076-34252021-10-011111140510.3390/brainsci11111405African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy PopulationsHarilanto Razafindrazaka0Veronica Pereda-Loth1Camille Ferdenzi2Margit Heiske3Omar Alva4Minah Randriamialisoa5Caroline Costedoat6Michel Signoli7Thierry Talou8Monique Courtade-Saidi9Anne Boland10Jean-François Deleuze11Catherine Rouby12Chantal Radimilahy13Thierry Letellier14Moustafa Bensafi15Denis Pierron16Aix Marseille University, CNRS, EFS, ADES, 13344 Marseille, FranceEquipe de Médecine Evolutive, URU EVOLSAN, Faculté de Chirurgie Dentaire, Université de Toulouse III, 31073 Toulouse, FranceCNRS, UMR5292, Lyon Neuroscience Research Center, University Lyon, 69000 Lyon, FranceEquipe de Médecine Evolutive, URU EVOLSAN, Faculté de Chirurgie Dentaire, Université de Toulouse III, 31073 Toulouse, FranceEquipe de Médecine Evolutive, URU EVOLSAN, Faculté de Chirurgie Dentaire, Université de Toulouse III, 31073 Toulouse, FranceDépartement Histoire, Faculté des Lettres et des Sciences Humaines, Université d’Antananarivo, Antananarivo 101, MadagascarAix Marseille University, CNRS, EFS, ADES, 13344 Marseille, FranceAix Marseille University, CNRS, EFS, ADES, 13344 Marseille, FranceLaboratoire de Chimie Agro-Industrielle, Université de Toulouse, INP-ENSIACET, 31030 Toulouse, FranceLaboratoire d’Histologie-Embryologie, Faculté de Médecine Rangueil, 31062 Toulouse, FranceCentre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, 91057 Evry, FranceCentre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, 91057 Evry, FranceCNRS, UMR5292, Lyon Neuroscience Research Center, University Lyon, 69000 Lyon, FranceInstitut de Civilisations/Musée d’Art et d’Archéologie, Université d’Antananarivo, Isoraka, Antananarivo 101, MadagascarEquipe de Médecine Evolutive, URU EVOLSAN, Faculté de Chirurgie Dentaire, Université de Toulouse III, 31073 Toulouse, FranceCNRS, UMR5292, Lyon Neuroscience Research Center, University Lyon, 69000 Lyon, FranceEquipe de Médecine Evolutive, URU EVOLSAN, Faculté de Chirurgie Dentaire, Université de Toulouse III, 31073 Toulouse, FranceWhile recent advances in genetics make it possible to follow the genetic exchanges between populations and their phenotypic consequences, the impact of the genetic exchanges on the sensory perception of populations has yet to be explored. From this perspective, the present study investigated the consequences of African gene flow on odor perception in a Malagasy population with a predominantly East Asian genetic background. To this end, we combined psychophysical tests with genotype data of 235 individuals who were asked to smell the odorant molecule beta-ionone (βI). Results showed that in this population the ancestry of the OR5A1 gene significantly influences the ability to detect βI. At the individual level, African ancestry significantly protects against specific anosmia/hyposmia due to the higher frequency of the functional gene (OR ratios = 14, CI: 1.8–110, <i>p</i>-value = 0.012). At the population level, African introgression decreased the prevalence of specific anosmia/hyposmia to this odorous compound. Taken together, these findings validate the conjecture that in addition to cultural exchanges, genetic transfer may also influence the sensory perception of the population in contact.https://www.mdpi.com/2076-3425/11/11/1405admixturebeta-iononeolfactionspecific anosmiaMadagascar |
| spellingShingle | Harilanto Razafindrazaka Veronica Pereda-Loth Camille Ferdenzi Margit Heiske Omar Alva Minah Randriamialisoa Caroline Costedoat Michel Signoli Thierry Talou Monique Courtade-Saidi Anne Boland Jean-François Deleuze Catherine Rouby Chantal Radimilahy Thierry Letellier Moustafa Bensafi Denis Pierron African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations Brain Sciences admixture beta-ionone olfaction specific anosmia Madagascar |
| title | African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations |
| title_full | African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations |
| title_fullStr | African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations |
| title_full_unstemmed | African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations |
| title_short | African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations |
| title_sort | african gene flow reduces beta ionone anosmia hyposmia prevalence in admixed malagasy populations |
| topic | admixture beta-ionone olfaction specific anosmia Madagascar |
| url | https://www.mdpi.com/2076-3425/11/11/1405 |
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