Safety studies with the oral rabies virus vaccine strain SPBN GASGAS in the small Indian mongoose (Herpestes auropunctatus)
Abstract Background Oral vaccination of the small Indian mongoose against rabies has been suggested as a potential tool to eliminate mongoose-mediated rabies on several Caribbean islands. A recently developed oral rabies virus vaccine strain, SPBN GASGAS, has already been shown to be efficacious in...
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| Format: | Article |
| Language: | English |
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BMC
2018-03-01
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| Series: | BMC Veterinary Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12917-018-1417-0 |
| _version_ | 1811278628205363200 |
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| author | Steffen Ortmann Ad Vos Antje Kretzschmar Nomusa Walther Christiane Kaiser Conrad Freuling Ivana Lojkic Thomas Müller |
| author_facet | Steffen Ortmann Ad Vos Antje Kretzschmar Nomusa Walther Christiane Kaiser Conrad Freuling Ivana Lojkic Thomas Müller |
| author_sort | Steffen Ortmann |
| collection | DOAJ |
| description | Abstract Background Oral vaccination of the small Indian mongoose against rabies has been suggested as a potential tool to eliminate mongoose-mediated rabies on several Caribbean islands. A recently developed oral rabies virus vaccine strain, SPBN GASGAS, has already been shown to be efficacious in this reservoir species. Since, all available oral rabies vaccines are based on replication-competent viruses and vaccine baits are distributed unsupervised in the environment, enhanced safety standards for such vaccine types are required. Results The results of safety studies, including overdose, repeated doses, dissemination and different routes of administration, in the target species are presented. It was shown that the construct was apathogenic, irrespective of dose and route of administration. Even when it was inoculated directly in the brain, it did not induce rabies infection. Furthermore, the vaccine strain did not spread within the target species after direct oral instillation beyond the site of entry. Conclusion The vaccine strain SPBN GASGAS meets the safety requirements for live rabies virus vaccines in this target species, the small Indian mongoose. |
| first_indexed | 2024-04-13T00:39:15Z |
| format | Article |
| id | doaj.art-b13d28be55a54ae589ecd468406a6ae8 |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-04-13T00:39:15Z |
| publishDate | 2018-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-b13d28be55a54ae589ecd468406a6ae82022-12-22T03:10:15ZengBMCBMC Veterinary Research1746-61482018-03-011411710.1186/s12917-018-1417-0Safety studies with the oral rabies virus vaccine strain SPBN GASGAS in the small Indian mongoose (Herpestes auropunctatus)Steffen Ortmann0Ad Vos1Antje Kretzschmar2Nomusa Walther3Christiane Kaiser4Conrad Freuling5Ivana Lojkic6Thomas Müller7IDT Biologika GmbHIDT Biologika GmbHIDT Biologika GmbHIDT Biologika GmbHIDT Biologika GmbHInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-InstituteDepartment of Virology, Croatian Veterinary InstituteInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-InstituteAbstract Background Oral vaccination of the small Indian mongoose against rabies has been suggested as a potential tool to eliminate mongoose-mediated rabies on several Caribbean islands. A recently developed oral rabies virus vaccine strain, SPBN GASGAS, has already been shown to be efficacious in this reservoir species. Since, all available oral rabies vaccines are based on replication-competent viruses and vaccine baits are distributed unsupervised in the environment, enhanced safety standards for such vaccine types are required. Results The results of safety studies, including overdose, repeated doses, dissemination and different routes of administration, in the target species are presented. It was shown that the construct was apathogenic, irrespective of dose and route of administration. Even when it was inoculated directly in the brain, it did not induce rabies infection. Furthermore, the vaccine strain did not spread within the target species after direct oral instillation beyond the site of entry. Conclusion The vaccine strain SPBN GASGAS meets the safety requirements for live rabies virus vaccines in this target species, the small Indian mongoose.http://link.springer.com/article/10.1186/s12917-018-1417-0RabiesMongooseOral vaccinationSafetySPBN GASGAS |
| spellingShingle | Steffen Ortmann Ad Vos Antje Kretzschmar Nomusa Walther Christiane Kaiser Conrad Freuling Ivana Lojkic Thomas Müller Safety studies with the oral rabies virus vaccine strain SPBN GASGAS in the small Indian mongoose (Herpestes auropunctatus) BMC Veterinary Research Rabies Mongoose Oral vaccination Safety SPBN GASGAS |
| title | Safety studies with the oral rabies virus vaccine strain SPBN GASGAS in the small Indian mongoose (Herpestes auropunctatus) |
| title_full | Safety studies with the oral rabies virus vaccine strain SPBN GASGAS in the small Indian mongoose (Herpestes auropunctatus) |
| title_fullStr | Safety studies with the oral rabies virus vaccine strain SPBN GASGAS in the small Indian mongoose (Herpestes auropunctatus) |
| title_full_unstemmed | Safety studies with the oral rabies virus vaccine strain SPBN GASGAS in the small Indian mongoose (Herpestes auropunctatus) |
| title_short | Safety studies with the oral rabies virus vaccine strain SPBN GASGAS in the small Indian mongoose (Herpestes auropunctatus) |
| title_sort | safety studies with the oral rabies virus vaccine strain spbn gasgas in the small indian mongoose herpestes auropunctatus |
| topic | Rabies Mongoose Oral vaccination Safety SPBN GASGAS |
| url | http://link.springer.com/article/10.1186/s12917-018-1417-0 |
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