Mechanisms of Homeostatic Synaptic Plasticity in vivo
Synapses undergo rapid activity-dependent plasticity to store information, which when left uncompensated can lead to destabilization of neural function. It has been well documented that homeostatic changes, which operate at a slower time scale, are required to maintain stability of neural networks....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-12-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2019.00520/full |
| _version_ | 1818486174548754432 |
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| author | Hey-Kyoung Lee Hey-Kyoung Lee Alfredo Kirkwood |
| author_facet | Hey-Kyoung Lee Hey-Kyoung Lee Alfredo Kirkwood |
| author_sort | Hey-Kyoung Lee |
| collection | DOAJ |
| description | Synapses undergo rapid activity-dependent plasticity to store information, which when left uncompensated can lead to destabilization of neural function. It has been well documented that homeostatic changes, which operate at a slower time scale, are required to maintain stability of neural networks. While there are many mechanisms that can endow homeostatic control, sliding threshold and synaptic scaling are unique in that they operate by providing homeostatic control of synaptic strength. The former mechanism operates by adjusting the threshold for synaptic plasticity, while the latter mechanism directly alters the gain of synapses. Both modes of homeostatic synaptic plasticity have been studied across various preparations from reduced in vitro systems, such as neuronal cultures, to in vivo intact circuitry. While most of the cellular and molecular mechanisms of homeostatic synaptic plasticity have been worked out using reduced preparations, there are unique challenges present in intact circuitry in vivo, which deserve further consideration. For example, in an intact circuit, neurons receive distinct set of inputs across their dendritic tree which carry unique information. Homeostatic synaptic plasticity in vivo needs to operate without compromising processing of these distinct set of inputs to preserve information processing while maintaining network stability. In this mini review, we will summarize unique features of in vivo homeostatic synaptic plasticity, and discuss how sliding threshold and synaptic scaling may act across different activity regimes to provide homeostasis. |
| first_indexed | 2024-12-10T16:19:23Z |
| format | Article |
| id | doaj.art-b13db1bc3fa5462c9d85b52639d9475a |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-10T16:19:23Z |
| publishDate | 2019-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-b13db1bc3fa5462c9d85b52639d9475a2022-12-22T01:41:53ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-12-011310.3389/fncel.2019.00520494579Mechanisms of Homeostatic Synaptic Plasticity in vivoHey-Kyoung Lee0Hey-Kyoung Lee1Alfredo Kirkwood2Department of Neuroscience, Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, United StatesKavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, United StatesDepartment of Neuroscience, Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, United StatesSynapses undergo rapid activity-dependent plasticity to store information, which when left uncompensated can lead to destabilization of neural function. It has been well documented that homeostatic changes, which operate at a slower time scale, are required to maintain stability of neural networks. While there are many mechanisms that can endow homeostatic control, sliding threshold and synaptic scaling are unique in that they operate by providing homeostatic control of synaptic strength. The former mechanism operates by adjusting the threshold for synaptic plasticity, while the latter mechanism directly alters the gain of synapses. Both modes of homeostatic synaptic plasticity have been studied across various preparations from reduced in vitro systems, such as neuronal cultures, to in vivo intact circuitry. While most of the cellular and molecular mechanisms of homeostatic synaptic plasticity have been worked out using reduced preparations, there are unique challenges present in intact circuitry in vivo, which deserve further consideration. For example, in an intact circuit, neurons receive distinct set of inputs across their dendritic tree which carry unique information. Homeostatic synaptic plasticity in vivo needs to operate without compromising processing of these distinct set of inputs to preserve information processing while maintaining network stability. In this mini review, we will summarize unique features of in vivo homeostatic synaptic plasticity, and discuss how sliding threshold and synaptic scaling may act across different activity regimes to provide homeostasis.https://www.frontiersin.org/article/10.3389/fncel.2019.00520/fullsliding thresholdmetaplasticityBCM theorysynaptic scalingcortical plasticityhomeostasis |
| spellingShingle | Hey-Kyoung Lee Hey-Kyoung Lee Alfredo Kirkwood Mechanisms of Homeostatic Synaptic Plasticity in vivo Frontiers in Cellular Neuroscience sliding threshold metaplasticity BCM theory synaptic scaling cortical plasticity homeostasis |
| title | Mechanisms of Homeostatic Synaptic Plasticity in vivo |
| title_full | Mechanisms of Homeostatic Synaptic Plasticity in vivo |
| title_fullStr | Mechanisms of Homeostatic Synaptic Plasticity in vivo |
| title_full_unstemmed | Mechanisms of Homeostatic Synaptic Plasticity in vivo |
| title_short | Mechanisms of Homeostatic Synaptic Plasticity in vivo |
| title_sort | mechanisms of homeostatic synaptic plasticity in vivo |
| topic | sliding threshold metaplasticity BCM theory synaptic scaling cortical plasticity homeostasis |
| url | https://www.frontiersin.org/article/10.3389/fncel.2019.00520/full |
| work_keys_str_mv | AT heykyounglee mechanismsofhomeostaticsynapticplasticityinvivo AT heykyounglee mechanismsofhomeostaticsynapticplasticityinvivo AT alfredokirkwood mechanismsofhomeostaticsynapticplasticityinvivo |