A Promising Biomolecule Able to Degrade Neutrophil Extracellular Traps: <i>Cdc</i>PDE, a Rattlesnake Phosphodiesterase

A Promising Biomolecule Able to Degrade Neutrophil Extracellular Traps: <i>Cdc</i>PDE, a Rattlesnake Phosphodiesterase

Neutrophil extracellular traps (NETs) are an important mechanism for defense against pathogens. Their overproduction can be harmful since excessive NET formation promotes inflammation and tissue damage in several diseases. Nucleases are capable to degrade NET on basis of their DNA hydrolysis activit...

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Bibliographic Details
Main Authors: Isadora Oliveira, Victor Costa, Flávio Veras, Isabela Ferreira, Fernando Cunha, Thiago Cunha, Wuelton Monteiro, Eliane Arantes, Manuela Pucca
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Toxins
Subjects:
phosphodiesterase
snake venom
<i>Cdc</i>PDE
svPDE
Online Access:https://www.mdpi.com/2072-6651/15/1/44
Description
Summary:Neutrophil extracellular traps (NETs) are an important mechanism for defense against pathogens. Their overproduction can be harmful since excessive NET formation promotes inflammation and tissue damage in several diseases. Nucleases are capable to degrade NET on basis of their DNA hydrolysis activity, including the <i>Cdc</i>PDE, a nuclease isolated from <i>Crotalus durissus collilineatus</i> snake venom. Here, we report a new finding about <i>Cdc</i>PDE activity, demonstrating its efficiency in degrading cell-free DNA from NETs, being a potential candidate to assist in therapies targeting inflammatory diseases.
ISSN:2072-6651

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