Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents
Background: Pregnant women are simultaneously exposed to several non-persistent endocrine-disrupting chemicals, which may influence the risk of childhood obesity and cardiovascular diseases later in life. Previous prospective studies have mostly examined single-chemical effects, with inconsistent fi...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Environment International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412022004548 |
| _version_ | 1797996856134860800 |
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| author | Nuria Güil-Oumrait German Cano-Sancho Parisa Montazeri Nikos Stratakis Charline Warembourg Maria-Jose Lopez-Espinosa Jesús Vioque Loreto Santa-Marina Alba Jimeno-Romero Rosa Ventura Nuria Monfort Martine Vrijheid Maribel Casas |
| author_facet | Nuria Güil-Oumrait German Cano-Sancho Parisa Montazeri Nikos Stratakis Charline Warembourg Maria-Jose Lopez-Espinosa Jesús Vioque Loreto Santa-Marina Alba Jimeno-Romero Rosa Ventura Nuria Monfort Martine Vrijheid Maribel Casas |
| author_sort | Nuria Güil-Oumrait |
| collection | DOAJ |
| description | Background: Pregnant women are simultaneously exposed to several non-persistent endocrine-disrupting chemicals, which may influence the risk of childhood obesity and cardiovascular diseases later in life. Previous prospective studies have mostly examined single-chemical effects, with inconsistent findings. We assessed the association between prenatal exposure to phthalates and phenols, individually and as a mixture, and body mass index (BMI) and blood pressure (BP) in preadolescents. Methods: We used data from the Spanish INMA birth cohort study (n = 1,015), where the 1st and 3rd- trimester maternal urinary concentrations of eight phthalate metabolites and six phenols were quantified. At 11 years of age, we calculated BMI z-scores and measured systolic and diastolic BP. We estimated individual chemical effects with linear mixed models and joint effects of the chemical mixture with hierarchical Bayesian kernel machine regression (BKMR). Analyses were stratified by sex and by puberty status. Results: In single-exposure models, benzophenone-3 (BP3) was nonmonotonically associated with higher BMI z-score (e.g. Quartile (Q) 3: β = 0.23 [95% CI = 0.03, 0.44] vs Q1) and higher diastolic BP (Q2: β = 1.27 [0.00, 2.53] mmHg vs Q1). Methyl paraben (MEPA) was associated with lower systolic BP (Q4: β = −1.67 [−3.31, −0.04] mmHg vs Q1). No consistent associations were observed for the other compounds. Results from the BKMR confirmed the single-exposure results and showed similar patterns of associations, with BP3 having the highest importance in the mixture models, especially among preadolescents who reached puberty status. No overall mixture effect was found, except for a tendency of higher BMI z-score and lower systolic BP in girls. Conclusions: Prenatal exposure to UV-filter BP3 may be associated with higher BMI and diastolic BP during preadolescence, but there is little evidence for an overall phthalate and phenol mixture effect. |
| first_indexed | 2024-04-11T10:24:08Z |
| format | Article |
| id | doaj.art-b140745398d1456e94fd7f5fff61a58d |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-04-11T10:24:08Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-b140745398d1456e94fd7f5fff61a58d2022-12-22T04:29:40ZengElsevierEnvironment International0160-41202022-11-01169107527Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescentsNuria Güil-Oumrait0German Cano-Sancho1Parisa Montazeri2Nikos Stratakis3Charline Warembourg4Maria-Jose Lopez-Espinosa5Jesús Vioque6Loreto Santa-Marina7Alba Jimeno-Romero8Rosa Ventura9Nuria Monfort10Martine Vrijheid11Maribel Casas12ISGlobal, Barcelona, Spain; Pompeu Fabra University (UPF), Barcelona, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, SpainLABERCA, UMR1329, Oniris, INRAE, Nantes, FranceISGlobal, Barcelona, Spain; Pompeu Fabra University (UPF), Barcelona, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, SpainISGlobal, Barcelona, Spain; Pompeu Fabra University (UPF), Barcelona, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, SpainUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, FranceCIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; FISABIO–Universitat Jaume I–Universitat de Valencia, Valencia, Spain; Faculty of Nursing and Chiropody, University of Valencia, Valencia, SpainCIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Universidad Miguel Hernández, Alicante, SpainCIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Biodonostia, Health Research Institute, Donostia, Gipuzkoa, Spain; Department of Health of the Basque Government, Subdirectorate of Public Health of Gipuzkoa, SpainCIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Biodonostia, Health Research Institute, Donostia, Gipuzkoa, Spain; Preventive Medicine and Public Health Department, University of the Basque Country, Leioa, Bizkaia, SpainCatalonian Antidoping Laboratory, Doping Control Research Group, IMIM, Barcelona, SpainCatalonian Antidoping Laboratory, Doping Control Research Group, IMIM, Barcelona, SpainISGlobal, Barcelona, Spain; Pompeu Fabra University (UPF), Barcelona, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, SpainISGlobal, Barcelona, Spain; Pompeu Fabra University (UPF), Barcelona, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Corresponding author at: Barcelona Institute for Global Health (ISGlobal), 88 Dr. Aiguader St., 08003 Barcelona, Spain.Background: Pregnant women are simultaneously exposed to several non-persistent endocrine-disrupting chemicals, which may influence the risk of childhood obesity and cardiovascular diseases later in life. Previous prospective studies have mostly examined single-chemical effects, with inconsistent findings. We assessed the association between prenatal exposure to phthalates and phenols, individually and as a mixture, and body mass index (BMI) and blood pressure (BP) in preadolescents. Methods: We used data from the Spanish INMA birth cohort study (n = 1,015), where the 1st and 3rd- trimester maternal urinary concentrations of eight phthalate metabolites and six phenols were quantified. At 11 years of age, we calculated BMI z-scores and measured systolic and diastolic BP. We estimated individual chemical effects with linear mixed models and joint effects of the chemical mixture with hierarchical Bayesian kernel machine regression (BKMR). Analyses were stratified by sex and by puberty status. Results: In single-exposure models, benzophenone-3 (BP3) was nonmonotonically associated with higher BMI z-score (e.g. Quartile (Q) 3: β = 0.23 [95% CI = 0.03, 0.44] vs Q1) and higher diastolic BP (Q2: β = 1.27 [0.00, 2.53] mmHg vs Q1). Methyl paraben (MEPA) was associated with lower systolic BP (Q4: β = −1.67 [−3.31, −0.04] mmHg vs Q1). No consistent associations were observed for the other compounds. Results from the BKMR confirmed the single-exposure results and showed similar patterns of associations, with BP3 having the highest importance in the mixture models, especially among preadolescents who reached puberty status. No overall mixture effect was found, except for a tendency of higher BMI z-score and lower systolic BP in girls. Conclusions: Prenatal exposure to UV-filter BP3 may be associated with higher BMI and diastolic BP during preadolescence, but there is little evidence for an overall phthalate and phenol mixture effect.http://www.sciencedirect.com/science/article/pii/S0160412022004548PhthalatesPhenolsParabensBenzophenone-3Body mass index (BMI)Blood pressure (BP) |
| spellingShingle | Nuria Güil-Oumrait German Cano-Sancho Parisa Montazeri Nikos Stratakis Charline Warembourg Maria-Jose Lopez-Espinosa Jesús Vioque Loreto Santa-Marina Alba Jimeno-Romero Rosa Ventura Nuria Monfort Martine Vrijheid Maribel Casas Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents Environment International Phthalates Phenols Parabens Benzophenone-3 Body mass index (BMI) Blood pressure (BP) |
| title | Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents |
| title_full | Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents |
| title_fullStr | Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents |
| title_full_unstemmed | Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents |
| title_short | Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents |
| title_sort | prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in spanish preadolescents |
| topic | Phthalates Phenols Parabens Benzophenone-3 Body mass index (BMI) Blood pressure (BP) |
| url | http://www.sciencedirect.com/science/article/pii/S0160412022004548 |
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