Phthalates exposure and pubertal development in a 15-year follow-up birth cohort study in Taiwan
PurposePhthalates are ubiquitous endocrine disruptors that can affect pubertal development in children. The association of fetal and childhood levels of phthalates with pubertal development were explored.MethodsWe conduct a population-based birth cohort study to investigate the association between p...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1065918/full |
| _version_ | 1797822010311573504 |
|---|---|
| author | Pen-Hua Su Pen-Hua Su Jing-Yang Huang Jing-Yang Huang Shu-Li Julie Wang Shu-Li Julie Wang Hua-Pin Chang |
| author_facet | Pen-Hua Su Pen-Hua Su Jing-Yang Huang Jing-Yang Huang Shu-Li Julie Wang Shu-Li Julie Wang Hua-Pin Chang |
| author_sort | Pen-Hua Su |
| collection | DOAJ |
| description | PurposePhthalates are ubiquitous endocrine disruptors that can affect pubertal development in children. The association of fetal and childhood levels of phthalates with pubertal development were explored.MethodsWe conduct a population-based birth cohort study to investigate the association between prenatal and childhood exposure to phthalates and pubertal development. Initially, a total of 445 children were recruited from 2000 to 2001, of which 90 children were followed for 15 years which measurements of urine and development assessed at 2, 5, 8, 11, and 14 years. We defined higher Tanner stage as the 14-year-old Tanner stage ≥ 4 and 5 for boys and girls, respectively. A logistic regression analysis was conducted to estimate the crude and adjusted odds ratio of a higher Tanner stage at 14 years old. The Pearson correlation coefficient and multiple linear regression were used to estimate the association of testicular volume, uterine volume, ovarian volume, and blood hormones at 14 years of age with the log-transformed concentration of phthalates at 2, 5, 8, 11, and 14 years.ResultsIn boys, a significantly different geometric mean of mono-benzyl phthalate (MBzP) was observed in 11-year-olds; 6.82 and 2.96 in the lower Tanner stage group and higher Tanner stage group. In girls, a significant difference in the geometric mean of mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) in 11-year-olds and mono-ethyl phthalate (MEP) in 2-year-olds was observed; MEHHP was 32.97 and 18.13 in the lower Tanner stage group and higher Tanner stage group, and MEP was 26.54 and 65.74 in the lower Tanner stage group and higher Tanner stage group, respectively. Uterine volume at 14 years old was negatively associated with several phthalate metabolites (MEHP at 8 years old, MnBP at 8 years old, MBzP at 14 years old, MMP prenatally, MMP at 8 years old, and MEP at 8 years old) after adjusting for covariates. However, no significant correlations were found between phthalate metabolites and ovarian or testicular volume.ConclusionPhthalate exposure at certain time points may influence the reproductive development of children during puberty; however, further studies should be conducted to determine the causal nature of this association. |
| first_indexed | 2024-03-13T10:02:27Z |
| format | Article |
| id | doaj.art-b1410d05e9e94ab6ad349d271c576b54 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-13T10:02:27Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-b1410d05e9e94ab6ad349d271c576b542023-05-23T05:04:52ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-05-011410.3389/fendo.2023.10659181065918Phthalates exposure and pubertal development in a 15-year follow-up birth cohort study in TaiwanPen-Hua Su0Pen-Hua Su1Jing-Yang Huang2Jing-Yang Huang3Shu-Li Julie Wang4Shu-Li Julie Wang5Hua-Pin Chang6Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Medical Research, Chung Shan Medical University Hospital, Taichung, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung, TaiwanNational Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, TaiwanDepartment of Public Health, National Defense Medical Center, Taipei, TaiwanDepartment of Nursing, Asia University, Taichung, TaiwanPurposePhthalates are ubiquitous endocrine disruptors that can affect pubertal development in children. The association of fetal and childhood levels of phthalates with pubertal development were explored.MethodsWe conduct a population-based birth cohort study to investigate the association between prenatal and childhood exposure to phthalates and pubertal development. Initially, a total of 445 children were recruited from 2000 to 2001, of which 90 children were followed for 15 years which measurements of urine and development assessed at 2, 5, 8, 11, and 14 years. We defined higher Tanner stage as the 14-year-old Tanner stage ≥ 4 and 5 for boys and girls, respectively. A logistic regression analysis was conducted to estimate the crude and adjusted odds ratio of a higher Tanner stage at 14 years old. The Pearson correlation coefficient and multiple linear regression were used to estimate the association of testicular volume, uterine volume, ovarian volume, and blood hormones at 14 years of age with the log-transformed concentration of phthalates at 2, 5, 8, 11, and 14 years.ResultsIn boys, a significantly different geometric mean of mono-benzyl phthalate (MBzP) was observed in 11-year-olds; 6.82 and 2.96 in the lower Tanner stage group and higher Tanner stage group. In girls, a significant difference in the geometric mean of mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) in 11-year-olds and mono-ethyl phthalate (MEP) in 2-year-olds was observed; MEHHP was 32.97 and 18.13 in the lower Tanner stage group and higher Tanner stage group, and MEP was 26.54 and 65.74 in the lower Tanner stage group and higher Tanner stage group, respectively. Uterine volume at 14 years old was negatively associated with several phthalate metabolites (MEHP at 8 years old, MnBP at 8 years old, MBzP at 14 years old, MMP prenatally, MMP at 8 years old, and MEP at 8 years old) after adjusting for covariates. However, no significant correlations were found between phthalate metabolites and ovarian or testicular volume.ConclusionPhthalate exposure at certain time points may influence the reproductive development of children during puberty; however, further studies should be conducted to determine the causal nature of this association.https://www.frontiersin.org/articles/10.3389/fendo.2023.1065918/fullphthalatesendocrine-disrupting chemicalspubertal developmentdevelopment of reproductive organsbirth cohort |
| spellingShingle | Pen-Hua Su Pen-Hua Su Jing-Yang Huang Jing-Yang Huang Shu-Li Julie Wang Shu-Li Julie Wang Hua-Pin Chang Phthalates exposure and pubertal development in a 15-year follow-up birth cohort study in Taiwan Frontiers in Endocrinology phthalates endocrine-disrupting chemicals pubertal development development of reproductive organs birth cohort |
| title | Phthalates exposure and pubertal development in a 15-year follow-up birth cohort study in Taiwan |
| title_full | Phthalates exposure and pubertal development in a 15-year follow-up birth cohort study in Taiwan |
| title_fullStr | Phthalates exposure and pubertal development in a 15-year follow-up birth cohort study in Taiwan |
| title_full_unstemmed | Phthalates exposure and pubertal development in a 15-year follow-up birth cohort study in Taiwan |
| title_short | Phthalates exposure and pubertal development in a 15-year follow-up birth cohort study in Taiwan |
| title_sort | phthalates exposure and pubertal development in a 15 year follow up birth cohort study in taiwan |
| topic | phthalates endocrine-disrupting chemicals pubertal development development of reproductive organs birth cohort |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1065918/full |
| work_keys_str_mv | AT penhuasu phthalatesexposureandpubertaldevelopmentina15yearfollowupbirthcohortstudyintaiwan AT penhuasu phthalatesexposureandpubertaldevelopmentina15yearfollowupbirthcohortstudyintaiwan AT jingyanghuang phthalatesexposureandpubertaldevelopmentina15yearfollowupbirthcohortstudyintaiwan AT jingyanghuang phthalatesexposureandpubertaldevelopmentina15yearfollowupbirthcohortstudyintaiwan AT shulijuliewang phthalatesexposureandpubertaldevelopmentina15yearfollowupbirthcohortstudyintaiwan AT shulijuliewang phthalatesexposureandpubertaldevelopmentina15yearfollowupbirthcohortstudyintaiwan AT huapinchang phthalatesexposureandpubertaldevelopmentina15yearfollowupbirthcohortstudyintaiwan |