LINE-1 retrotransposons and Let-7 miRNA: partners in the pathogenesis of cancer?
LINE-1 retrotransposons are insertional mutagens capable of altering the genomic landscape in many ways. Activation of the normally silent LINE-1 retrotransposon is associated with a high level of cancer-associated DNA damage and genomic instability. Studies of LINE-1 have so far focused mainly on c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-10-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00338/full |
| _version_ | 1818931167887360000 |
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| author | Stephen eOhms Sung-Hun eLee Danny eRangasamy |
| author_facet | Stephen eOhms Sung-Hun eLee Danny eRangasamy |
| author_sort | Stephen eOhms |
| collection | DOAJ |
| description | LINE-1 retrotransposons are insertional mutagens capable of altering the genomic landscape in many ways. Activation of the normally silent LINE-1 retrotransposon is associated with a high level of cancer-associated DNA damage and genomic instability. Studies of LINE-1 have so far focused mainly on changes in gene expression, and our knowledge of its impact on functional noncoding RNAs is in its infancy. However, current evidence suggests that a significant number of human miRNAs originate from retrotransposon sequences. Furthermore, LINE-1 is generally not expressed in normal tissues while its expression is widespread in epithelial cancers. Based on our recent studies, we demonstrate a functional link between aberrant LINE-1 expression and deregulation of let-7 miRNA expression. Since the expression of let-7 is modulated by LINE-1 activity, we discuss possible mechanisms for this effect and how the silencing of LINE-1 activation could provide new therapeutic options for cancer treatment. Based on the deep sequencing of small RNAs in parallel with gene expression profiling in breast cancer cells, we have identified potential pathways linking L1 activity to let-7 processing and maturation and ultimately to the control of stemness in |
| first_indexed | 2024-12-20T04:12:18Z |
| format | Article |
| id | doaj.art-b1418b498edc4a259db76854f38e879f |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-20T04:12:18Z |
| publishDate | 2014-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-b1418b498edc4a259db76854f38e879f2022-12-21T19:53:51ZengFrontiers Media S.A.Frontiers in Genetics1664-80212014-10-01510.3389/fgene.2014.00338114712LINE-1 retrotransposons and Let-7 miRNA: partners in the pathogenesis of cancer?Stephen eOhms0Sung-Hun eLee1Danny eRangasamy2Australian National UniversityThe University of Texas MD Anderson Cancer CenterAustralian National UniversityLINE-1 retrotransposons are insertional mutagens capable of altering the genomic landscape in many ways. Activation of the normally silent LINE-1 retrotransposon is associated with a high level of cancer-associated DNA damage and genomic instability. Studies of LINE-1 have so far focused mainly on changes in gene expression, and our knowledge of its impact on functional noncoding RNAs is in its infancy. However, current evidence suggests that a significant number of human miRNAs originate from retrotransposon sequences. Furthermore, LINE-1 is generally not expressed in normal tissues while its expression is widespread in epithelial cancers. Based on our recent studies, we demonstrate a functional link between aberrant LINE-1 expression and deregulation of let-7 miRNA expression. Since the expression of let-7 is modulated by LINE-1 activity, we discuss possible mechanisms for this effect and how the silencing of LINE-1 activation could provide new therapeutic options for cancer treatment. Based on the deep sequencing of small RNAs in parallel with gene expression profiling in breast cancer cells, we have identified potential pathways linking L1 activity to let-7 processing and maturation and ultimately to the control of stemness inhttp://journal.frontiersin.org/Journal/10.3389/fgene.2014.00338/fullCancerLINE-1retrotransposonlong noncoding RNAgene modulationlet-7 microRNA |
| spellingShingle | Stephen eOhms Sung-Hun eLee Danny eRangasamy LINE-1 retrotransposons and Let-7 miRNA: partners in the pathogenesis of cancer? Frontiers in Genetics Cancer LINE-1 retrotransposon long noncoding RNA gene modulation let-7 microRNA |
| title | LINE-1 retrotransposons and Let-7 miRNA: partners in the pathogenesis of cancer? |
| title_full | LINE-1 retrotransposons and Let-7 miRNA: partners in the pathogenesis of cancer? |
| title_fullStr | LINE-1 retrotransposons and Let-7 miRNA: partners in the pathogenesis of cancer? |
| title_full_unstemmed | LINE-1 retrotransposons and Let-7 miRNA: partners in the pathogenesis of cancer? |
| title_short | LINE-1 retrotransposons and Let-7 miRNA: partners in the pathogenesis of cancer? |
| title_sort | line 1 retrotransposons and let 7 mirna partners in the pathogenesis of cancer |
| topic | Cancer LINE-1 retrotransposon long noncoding RNA gene modulation let-7 microRNA |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00338/full |
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