LINE-1 retrotransposons and Let-7 miRNA: partners in the pathogenesis of cancer?

LINE-1 retrotransposons and Let-7 miRNA: partners in the pathogenesis of cancer?

LINE-1 retrotransposons are insertional mutagens capable of altering the genomic landscape in many ways. Activation of the normally silent LINE-1 retrotransposon is associated with a high level of cancer-associated DNA damage and genomic instability. Studies of LINE-1 have so far focused mainly on c...

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Bibliographic Details
Main Authors: Stephen eOhms, Sung-Hun eLee, Danny eRangasamy
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Genetics
Subjects:
Cancer
LINE-1
retrotransposon
long noncoding RNA
gene modulation
let-7 microRNA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00338/full

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