Effects of maternal iodine nutritional status on neurodevelopmental and cognitive function of rat offspring
ObjectivesThis study aimed to explore the effect of maternal iodine status on the brain development of offspring in rats. Since in human studies, the interference of environmental factors and other nutrients cannot be removed.Materials and methodsA total of 48 female Wistar rats were randomly divide...
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.996092/full |
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| author | Min Fu Min Fu Wen Wu Wen Wu Wenxing Guo Wenxing Guo Qi Jin Qi Jin Qi Meng Qi Meng Yuanpeng Gao Yuanpeng Gao Rui Yang Rui Yang Ying Yang Ying Yang Zihao Wang Wanqi Zhang Wanqi Zhang Wanqi Zhang |
| author_facet | Min Fu Min Fu Wen Wu Wen Wu Wenxing Guo Wenxing Guo Qi Jin Qi Jin Qi Meng Qi Meng Yuanpeng Gao Yuanpeng Gao Rui Yang Rui Yang Ying Yang Ying Yang Zihao Wang Wanqi Zhang Wanqi Zhang Wanqi Zhang |
| author_sort | Min Fu |
| collection | DOAJ |
| description | ObjectivesThis study aimed to explore the effect of maternal iodine status on the brain development of offspring in rats. Since in human studies, the interference of environmental factors and other nutrients cannot be removed.Materials and methodsA total of 48 female Wistar rats were randomly divided into four groups: low iodine (LI), normal iodine (NI), 10-fold high iodine (10HI), and 50-fold high iodine (50HI). The rats were killed on the 15th day of pregnancy and lactation after collecting 24-h urine. The iodine concentration in 24-h urine, blood, and placenta of pregnant rats, and 24-h urine, milk, blood, and mammary glands of lactating rats was determined by inductively coupled plasma mass spectrometry. The thyroid hormone of pregnant and lactating rats was detected by chemiluminescence. The offspring were subjected to the Morris water maze on the 10th day after birth. Serum was collected to detect the thyroid hormone of offspring. The protein expression of neuroendocrine-specific protein (NSP)-A and brain-derived neurotrophic factor (BDNF) in the offspring brain were studied.ResultsIodine storage in the placenta during pregnancy and mammary glands during lactation was positively correlated with iodine intake, and iodine storage in the placenta and mammary glands in the 50HI group was significantly higher than that in the NI group (P = 0.045 and P = 0.040). Compared with the NI group, the offspring thyroid-stimulating hormone (TSH) level was significantly higher in the 10HI group (P = 0.046), and the FT4 level was significantly lower in the 50HI group (P = 0.032). The Morris water maze showed that LI and 50HI groups required longer time and distance to find the platform than the NI group (P < 0.001). The platform crossing numbers in the LI and 50HI groups decreased significantly (P < 0.001). The expression of NSP-A in offspring brain was lower in the 10HI and 50HI groups than in the NI group (P = 0.026 and P = 0,008). BDNF expression levels were significantly lower in the LI, 10HI, and 50HI groups than in the NI group (P < 0.001).ConclusionMaternal iodine intake affects iodine storage in the placenta and lactating mammary gland, which in turn affects thyroid function and BDNF and NSP-A expression in the offspring. |
| first_indexed | 2024-04-12T12:21:20Z |
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| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-12T12:21:20Z |
| publishDate | 2022-10-01 |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-b141e7e0151f4ca4b187c5638861817d2022-12-22T03:33:17ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-10-01910.3389/fnut.2022.996092996092Effects of maternal iodine nutritional status on neurodevelopmental and cognitive function of rat offspringMin Fu0Min Fu1Wen Wu2Wen Wu3Wenxing Guo4Wenxing Guo5Qi Jin6Qi Jin7Qi Meng8Qi Meng9Yuanpeng Gao10Yuanpeng Gao11Rui Yang12Rui Yang13Ying Yang14Ying Yang15Zihao Wang16Wanqi Zhang17Wanqi Zhang18Wanqi Zhang19Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, ChinaTianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, ChinaDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, ChinaTianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, ChinaDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, ChinaTianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, ChinaDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, ChinaTianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, ChinaDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, ChinaTianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, ChinaDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, ChinaTianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, ChinaDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, ChinaTianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, ChinaDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, ChinaTianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, ChinaDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, ChinaDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, ChinaTianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, ChinaDepartment of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, ChinaObjectivesThis study aimed to explore the effect of maternal iodine status on the brain development of offspring in rats. Since in human studies, the interference of environmental factors and other nutrients cannot be removed.Materials and methodsA total of 48 female Wistar rats were randomly divided into four groups: low iodine (LI), normal iodine (NI), 10-fold high iodine (10HI), and 50-fold high iodine (50HI). The rats were killed on the 15th day of pregnancy and lactation after collecting 24-h urine. The iodine concentration in 24-h urine, blood, and placenta of pregnant rats, and 24-h urine, milk, blood, and mammary glands of lactating rats was determined by inductively coupled plasma mass spectrometry. The thyroid hormone of pregnant and lactating rats was detected by chemiluminescence. The offspring were subjected to the Morris water maze on the 10th day after birth. Serum was collected to detect the thyroid hormone of offspring. The protein expression of neuroendocrine-specific protein (NSP)-A and brain-derived neurotrophic factor (BDNF) in the offspring brain were studied.ResultsIodine storage in the placenta during pregnancy and mammary glands during lactation was positively correlated with iodine intake, and iodine storage in the placenta and mammary glands in the 50HI group was significantly higher than that in the NI group (P = 0.045 and P = 0.040). Compared with the NI group, the offspring thyroid-stimulating hormone (TSH) level was significantly higher in the 10HI group (P = 0.046), and the FT4 level was significantly lower in the 50HI group (P = 0.032). The Morris water maze showed that LI and 50HI groups required longer time and distance to find the platform than the NI group (P < 0.001). The platform crossing numbers in the LI and 50HI groups decreased significantly (P < 0.001). The expression of NSP-A in offspring brain was lower in the 10HI and 50HI groups than in the NI group (P = 0.026 and P = 0,008). BDNF expression levels were significantly lower in the LI, 10HI, and 50HI groups than in the NI group (P < 0.001).ConclusionMaternal iodine intake affects iodine storage in the placenta and lactating mammary gland, which in turn affects thyroid function and BDNF and NSP-A expression in the offspring.https://www.frontiersin.org/articles/10.3389/fnut.2022.996092/fullmaternal iodine excessmaternal iodine deficiencyoffspring neurodevelopmentplacentamammary gland |
| spellingShingle | Min Fu Min Fu Wen Wu Wen Wu Wenxing Guo Wenxing Guo Qi Jin Qi Jin Qi Meng Qi Meng Yuanpeng Gao Yuanpeng Gao Rui Yang Rui Yang Ying Yang Ying Yang Zihao Wang Wanqi Zhang Wanqi Zhang Wanqi Zhang Effects of maternal iodine nutritional status on neurodevelopmental and cognitive function of rat offspring Frontiers in Nutrition maternal iodine excess maternal iodine deficiency offspring neurodevelopment placenta mammary gland |
| title | Effects of maternal iodine nutritional status on neurodevelopmental and cognitive function of rat offspring |
| title_full | Effects of maternal iodine nutritional status on neurodevelopmental and cognitive function of rat offspring |
| title_fullStr | Effects of maternal iodine nutritional status on neurodevelopmental and cognitive function of rat offspring |
| title_full_unstemmed | Effects of maternal iodine nutritional status on neurodevelopmental and cognitive function of rat offspring |
| title_short | Effects of maternal iodine nutritional status on neurodevelopmental and cognitive function of rat offspring |
| title_sort | effects of maternal iodine nutritional status on neurodevelopmental and cognitive function of rat offspring |
| topic | maternal iodine excess maternal iodine deficiency offspring neurodevelopment placenta mammary gland |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.996092/full |
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