CHRONIC MYELOMONOCYTIC LEUKEMIA - REVIEW AND CLINICAL EXPERIENCE OF THE HEMATOLOGY DEPARTMENT UMHAT "ST. MARINA" - VARNA
Chronic myelomonocytic leukemia (CMML) is a rare de novo myeloid neoplasm that exhibits dysplastic and proliferative features at presentation. The diagnosis is problematic with several specific controversial issues. Aim: To analyze the cases with CMML diagnosed in the Hematology clinic, UMHAT “St....
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| Format: | Article |
| Language: | English |
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Peytchinski Publishing
2016-03-01
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| Series: | Journal of IMAB |
| Subjects: | |
| Online Access: | http://www.journal-imab-bg.org/issues-2016/issue1/JofIMAB_2016-22-1p1091-1095.pdf |
| _version_ | 1818318952532541440 |
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| author | Ilina Micheva Trifon Chervenkov Canka Ruseva Liana Gercheva |
| author_facet | Ilina Micheva Trifon Chervenkov Canka Ruseva Liana Gercheva |
| author_sort | Ilina Micheva |
| collection | DOAJ |
| description | Chronic myelomonocytic leukemia (CMML) is a rare de novo myeloid neoplasm that exhibits dysplastic and proliferative features at presentation. The diagnosis is problematic with several specific controversial issues.
Aim: To analyze the cases with CMML diagnosed in the Hematology clinic, UMHAT “St. Marina”, Varna with assessment of risk, prognosis and survival.
Materials and methods: The results from cytology, flow cytometry, histology, and genetics are re-estimated. For the risk stratification the CPSS was used. The statistical analysis is performed using SPSS 19.
Results: Fifteen patients with CMML, 12 men and 3 women, with median age of 69,8 years were included in the study. According to the leukocyte count 12 were myeloproliferative (CMML/MP) and 3 myelodysplastic CMML (CMML/MD). The flow cytometry of peripheral blood and bone marrow was characterized by CD14, CD64, CD16 and CD56 expression. According to the histology of the bone marrow 2 cases were described as MDS, 1 as MDS/MPN, the rest as MPN with fibrosis in two of the cases. The cytogenetic risk was high in 5 patients and low in 10. According to CPSS one patient was with low risk, 3 with intermediate 1, 9 with intermediate 2 and 2 with high risk. Acute myeloid leukemia transformation occurred in 9 patients within median period of 13.1 months. The median survival after transformation was 2,5 months. The median survival in the whole group was 21.4 months. Conclusion: CMML is an aggressive disease. The prognosis of patients with CMML is poor, with low survival and high risk of transformation. The therapeutic options are limited. |
| first_indexed | 2024-12-13T10:01:24Z |
| format | Article |
| id | doaj.art-b1422a3b8e8b4ac481c61b7ed5a92545 |
| institution | Directory Open Access Journal |
| issn | 1312-773X |
| language | English |
| last_indexed | 2024-12-13T10:01:24Z |
| publishDate | 2016-03-01 |
| publisher | Peytchinski Publishing |
| record_format | Article |
| series | Journal of IMAB |
| spelling | doaj.art-b1422a3b8e8b4ac481c61b7ed5a925452022-12-21T23:51:40ZengPeytchinski PublishingJournal of IMAB1312-773X2016-03-012211091109510.5272/jimab.2016221.1091CHRONIC MYELOMONOCYTIC LEUKEMIA - REVIEW AND CLINICAL EXPERIENCE OF THE HEMATOLOGY DEPARTMENT UMHAT "ST. MARINA" - VARNAIlina Micheva0Trifon Chervenkov1Canka Ruseva2Liana Gercheva3Clinic of Hematology, Medical University, Varna, University Hospital “St. Marina“, Varna, BulgariaLaboratory of Clinical Immunology, Medical University, Varna, University Hospital “St. Marina“, Varna, BulgariaLaboratory of Medical Genetics, Medical University, Varna, University Hospital “St. Marina“, Varna, Bulgaria.Clinic of Hematology, Medical University, Varna, University Hospital “St. Marina“, Varna, BulgariaChronic myelomonocytic leukemia (CMML) is a rare de novo myeloid neoplasm that exhibits dysplastic and proliferative features at presentation. The diagnosis is problematic with several specific controversial issues. Aim: To analyze the cases with CMML diagnosed in the Hematology clinic, UMHAT “St. Marina”, Varna with assessment of risk, prognosis and survival. Materials and methods: The results from cytology, flow cytometry, histology, and genetics are re-estimated. For the risk stratification the CPSS was used. The statistical analysis is performed using SPSS 19. Results: Fifteen patients with CMML, 12 men and 3 women, with median age of 69,8 years were included in the study. According to the leukocyte count 12 were myeloproliferative (CMML/MP) and 3 myelodysplastic CMML (CMML/MD). The flow cytometry of peripheral blood and bone marrow was characterized by CD14, CD64, CD16 and CD56 expression. According to the histology of the bone marrow 2 cases were described as MDS, 1 as MDS/MPN, the rest as MPN with fibrosis in two of the cases. The cytogenetic risk was high in 5 patients and low in 10. According to CPSS one patient was with low risk, 3 with intermediate 1, 9 with intermediate 2 and 2 with high risk. Acute myeloid leukemia transformation occurred in 9 patients within median period of 13.1 months. The median survival after transformation was 2,5 months. The median survival in the whole group was 21.4 months. Conclusion: CMML is an aggressive disease. The prognosis of patients with CMML is poor, with low survival and high risk of transformation. The therapeutic options are limited.http://www.journal-imab-bg.org/issues-2016/issue1/JofIMAB_2016-22-1p1091-1095.pdfChronic myelomonocytic leukemiarisk stratificationsurvival |
| spellingShingle | Ilina Micheva Trifon Chervenkov Canka Ruseva Liana Gercheva CHRONIC MYELOMONOCYTIC LEUKEMIA - REVIEW AND CLINICAL EXPERIENCE OF THE HEMATOLOGY DEPARTMENT UMHAT "ST. MARINA" - VARNA Journal of IMAB Chronic myelomonocytic leukemia risk stratification survival |
| title | CHRONIC MYELOMONOCYTIC LEUKEMIA - REVIEW AND CLINICAL EXPERIENCE OF THE HEMATOLOGY DEPARTMENT UMHAT "ST. MARINA" - VARNA |
| title_full | CHRONIC MYELOMONOCYTIC LEUKEMIA - REVIEW AND CLINICAL EXPERIENCE OF THE HEMATOLOGY DEPARTMENT UMHAT "ST. MARINA" - VARNA |
| title_fullStr | CHRONIC MYELOMONOCYTIC LEUKEMIA - REVIEW AND CLINICAL EXPERIENCE OF THE HEMATOLOGY DEPARTMENT UMHAT "ST. MARINA" - VARNA |
| title_full_unstemmed | CHRONIC MYELOMONOCYTIC LEUKEMIA - REVIEW AND CLINICAL EXPERIENCE OF THE HEMATOLOGY DEPARTMENT UMHAT "ST. MARINA" - VARNA |
| title_short | CHRONIC MYELOMONOCYTIC LEUKEMIA - REVIEW AND CLINICAL EXPERIENCE OF THE HEMATOLOGY DEPARTMENT UMHAT "ST. MARINA" - VARNA |
| title_sort | chronic myelomonocytic leukemia review and clinical experience of the hematology department umhat st marina varna |
| topic | Chronic myelomonocytic leukemia risk stratification survival |
| url | http://www.journal-imab-bg.org/issues-2016/issue1/JofIMAB_2016-22-1p1091-1095.pdf |
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