INFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODEL
Abstract. Mediators of inflammation may play a sufficient role in destabilization of atherosclerotic plaque, disturbing the balance between collagen formation and its degradation in fibrotic capsule. Using a transgenic murine model, the effects of induced inflammation upon expression of factors dete...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/254 |
| _version_ | 1797198110531780608 |
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| author | E. V. Shlyakhto N. A. Gavrisheva O. A. Ovchinnikova G. K. Hansson |
| author_facet | E. V. Shlyakhto N. A. Gavrisheva O. A. Ovchinnikova G. K. Hansson |
| author_sort | E. V. Shlyakhto |
| collection | DOAJ |
| description | Abstract. Mediators of inflammation may play a sufficient role in destabilization of atherosclerotic plaque, disturbing the balance between collagen formation and its degradation in fibrotic capsule. Using a transgenic murine model, the effects of induced inflammation upon expression of factors determining posttranslational modification and degradation of collagen, i.e., prolyl-4-hydroxylase, matrix metalloproteinases-2, -9 (MMP-2, -9), and tissue inhibitor of metalloproteinases (TIMP-1) were evaluated. It has been shown that, under significant increase of interferon-γ and interleukin-1β, the synthesis of prolyl-4-hydroxylase and MMP - 9 is decreased, whereas expression of collagen, MMP-2 and TIMP-1 genes was not changed. (Med. Immunol., vol. 10, N 6, pp 507-512). |
| first_indexed | 2024-03-08T05:51:53Z |
| format | Article |
| id | doaj.art-b14599d6e8bd46ada8b3b15770e9cd40 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:54:39Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-b14599d6e8bd46ada8b3b15770e9cd402024-04-22T13:07:35ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0110650751210.15789/1563-0625-2008-6-507-512251INFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODELE. V. Shlyakhto0N. A. Gavrisheva1O. A. Ovchinnikova2G. K. Hansson3Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова, Санкт-ПетербургСанкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова, Санкт-ПетербургСанкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова, Санкт-ПетербургКаролинский институт, СтокгольмAbstract. Mediators of inflammation may play a sufficient role in destabilization of atherosclerotic plaque, disturbing the balance between collagen formation and its degradation in fibrotic capsule. Using a transgenic murine model, the effects of induced inflammation upon expression of factors determining posttranslational modification and degradation of collagen, i.e., prolyl-4-hydroxylase, matrix metalloproteinases-2, -9 (MMP-2, -9), and tissue inhibitor of metalloproteinases (TIMP-1) were evaluated. It has been shown that, under significant increase of interferon-γ and interleukin-1β, the synthesis of prolyl-4-hydroxylase and MMP - 9 is decreased, whereas expression of collagen, MMP-2 and TIMP-1 genes was not changed. (Med. Immunol., vol. 10, N 6, pp 507-512).https://www.mimmun.ru/mimmun/article/view/254atherosclerotic plaqueinflammationcollagenmetalloproteinasesmurine model |
| spellingShingle | E. V. Shlyakhto N. A. Gavrisheva O. A. Ovchinnikova G. K. Hansson INFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODEL Медицинская иммунология atherosclerotic plaque inflammation collagen metalloproteinases murine model |
| title | INFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODEL |
| title_full | INFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODEL |
| title_fullStr | INFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODEL |
| title_full_unstemmed | INFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODEL |
| title_short | INFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODEL |
| title_sort | influence of induced inflammation upon collagen metabolism of unstable atherosclerotic plaque in murine model |
| topic | atherosclerotic plaque inflammation collagen metalloproteinases murine model |
| url | https://www.mimmun.ru/mimmun/article/view/254 |
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