The effect of Lactobacillus casei and Bifidobacterium breve on antibiotic-associated diarrhea treatment: randomized double-blind clinical trial
INTRODUCTION: Antibiotic-associated diarrhea (AAD) is an important side effect of this specific class of drugs. The objective of this study was to investigate the effect of the use of probiotics in the treatment of AAD. METHODS: A group of hospitalized patients, who contracted diarrhea during or aft...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Medicina Tropical (SBMT)
2012-02-01
|
| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000100021&lng=en&tlng=en |
| _version_ | 1817977197766377472 |
|---|---|
| author | Daniela Nogueira Prado de Souza Miguel Tanús Jorge |
| author_facet | Daniela Nogueira Prado de Souza Miguel Tanús Jorge |
| author_sort | Daniela Nogueira Prado de Souza |
| collection | DOAJ |
| description | INTRODUCTION: Antibiotic-associated diarrhea (AAD) is an important side effect of this specific class of drugs. The objective of this study was to investigate the effect of the use of probiotics in the treatment of AAD. METHODS: A group of hospitalized patients, who contracted diarrhea during or after 7 days of suspension of antimicrobial medication, was blindly randomized to receive a standardized diet associated with the use of the probiotics (Lactobacillus casei and Bifidobacterium breve) or its corresponding placebo, three times a day. RESULTS: Seventy patients were studied. For the experimental (n=35) and control (n=35) groups, respectively, the average time of treatment was 5.06±2.18 and 5.49±3.17 days (p=0.95), and the average duration of diarrhea, among those who were healed, was 4.87±2.13 and 4.52±2.55 days (p=0.36). Four (11.4%) patients who received probiotics and ten (28.6%) who received the placebo were not cured (p=0.13), and relapse rates were similar between both groups. Seven patients from each group, in addition to diarrhea, presented cases of bloating and/or abdominal cramps and/or vomiting (p=1.00). CONCLUSIONS: In this light, it is concluded that L. casei associated with B. breve, in the administered dosage and frequency, has no effect on the antibiotic-associated diarrhea. Similar studies need to be conducted with higher doses of these or other probiotics. |
| first_indexed | 2024-04-13T22:13:02Z |
| format | Article |
| id | doaj.art-b146a517d53a4382b917eff94e8d7970 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-13T22:13:02Z |
| publishDate | 2012-02-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-b146a517d53a4382b917eff94e8d79702022-12-22T02:27:39ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492012-02-0145111211610.1590/S0037-86822012000100021S0037-86822012000100021The effect of Lactobacillus casei and Bifidobacterium breve on antibiotic-associated diarrhea treatment: randomized double-blind clinical trialDaniela Nogueira Prado de Souza0Miguel Tanús Jorge1Universidade Federal de UberlândiaUniversidade Federal de UberlândiaINTRODUCTION: Antibiotic-associated diarrhea (AAD) is an important side effect of this specific class of drugs. The objective of this study was to investigate the effect of the use of probiotics in the treatment of AAD. METHODS: A group of hospitalized patients, who contracted diarrhea during or after 7 days of suspension of antimicrobial medication, was blindly randomized to receive a standardized diet associated with the use of the probiotics (Lactobacillus casei and Bifidobacterium breve) or its corresponding placebo, three times a day. RESULTS: Seventy patients were studied. For the experimental (n=35) and control (n=35) groups, respectively, the average time of treatment was 5.06±2.18 and 5.49±3.17 days (p=0.95), and the average duration of diarrhea, among those who were healed, was 4.87±2.13 and 4.52±2.55 days (p=0.36). Four (11.4%) patients who received probiotics and ten (28.6%) who received the placebo were not cured (p=0.13), and relapse rates were similar between both groups. Seven patients from each group, in addition to diarrhea, presented cases of bloating and/or abdominal cramps and/or vomiting (p=1.00). CONCLUSIONS: In this light, it is concluded that L. casei associated with B. breve, in the administered dosage and frequency, has no effect on the antibiotic-associated diarrhea. Similar studies need to be conducted with higher doses of these or other probiotics.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000100021&lng=en&tlng=enProbióticosBifidobacterium breveDiarréia associada ao uso de antimicrobiano |
| spellingShingle | Daniela Nogueira Prado de Souza Miguel Tanús Jorge The effect of Lactobacillus casei and Bifidobacterium breve on antibiotic-associated diarrhea treatment: randomized double-blind clinical trial Revista da Sociedade Brasileira de Medicina Tropical Probióticos Bifidobacterium breve Diarréia associada ao uso de antimicrobiano |
| title | The effect of Lactobacillus casei and Bifidobacterium breve on antibiotic-associated diarrhea treatment: randomized double-blind clinical trial |
| title_full | The effect of Lactobacillus casei and Bifidobacterium breve on antibiotic-associated diarrhea treatment: randomized double-blind clinical trial |
| title_fullStr | The effect of Lactobacillus casei and Bifidobacterium breve on antibiotic-associated diarrhea treatment: randomized double-blind clinical trial |
| title_full_unstemmed | The effect of Lactobacillus casei and Bifidobacterium breve on antibiotic-associated diarrhea treatment: randomized double-blind clinical trial |
| title_short | The effect of Lactobacillus casei and Bifidobacterium breve on antibiotic-associated diarrhea treatment: randomized double-blind clinical trial |
| title_sort | effect of lactobacillus casei and bifidobacterium breve on antibiotic associated diarrhea treatment randomized double blind clinical trial |
| topic | Probióticos Bifidobacterium breve Diarréia associada ao uso de antimicrobiano |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000100021&lng=en&tlng=en |
| work_keys_str_mv | AT danielanogueirapradodesouza theeffectoflactobacilluscaseiandbifidobacteriumbreveonantibioticassociateddiarrheatreatmentrandomizeddoubleblindclinicaltrial AT migueltanusjorge theeffectoflactobacilluscaseiandbifidobacteriumbreveonantibioticassociateddiarrheatreatmentrandomizeddoubleblindclinicaltrial AT danielanogueirapradodesouza effectoflactobacilluscaseiandbifidobacteriumbreveonantibioticassociateddiarrheatreatmentrandomizeddoubleblindclinicaltrial AT migueltanusjorge effectoflactobacilluscaseiandbifidobacteriumbreveonantibioticassociateddiarrheatreatmentrandomizeddoubleblindclinicaltrial |