Quality of life in patients with achalasia: Associations with Eckardt score and objective treatment outcomes after peroral endoscopic myotomy
Background and study aims Knowledge on self-reported quality of life (QoL) in achalasia and QoL improvements after peroral endoscopic myotomy (POEM) is limited. Furthermore, the clinical role of QoL in achalasia follow-up has not been evaluated. The present study aimed to examine QoL in achalasia pa...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Georg Thieme Verlag KG
2022-12-01
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| Series: | Endoscopy International Open |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1968-7682 |
| _version_ | 1811195701754855424 |
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| author | Helge Evensen Marianne Jensen Hjermstad Milada Cvancarova Vendel Kristensen Lene Larssen Jorunn Skattum Truls Hauge Olav Sandstad Asle W. Medhus |
| author_facet | Helge Evensen Marianne Jensen Hjermstad Milada Cvancarova Vendel Kristensen Lene Larssen Jorunn Skattum Truls Hauge Olav Sandstad Asle W. Medhus |
| author_sort | Helge Evensen |
| collection | DOAJ |
| description | Background and study aims Knowledge on self-reported quality of life (QoL) in achalasia and QoL improvements after peroral endoscopic myotomy (POEM) is limited. Furthermore, the clinical role of QoL in achalasia follow-up has not been evaluated. The present study aimed to examine QoL in achalasia patients before and after POEM and assess associations between QoL, Eckardt score (ES) and objective results.
Patients and methods This was a single-center prospective study of treatment-naïve achalasia patients with 12-month follow-up after POEM including manometry, upper endoscopy, 24-hour pH registration, and timed barium esophagogram. QoL data were registered using European Organisation for Research and Treatment of Cancer core questionnaire (QLQ-C30) and esophageal module (QLQ-OES18). Comparison with a reference population was performed to assess impact of achalasia on QoL and effect of therapy. Mixed models for repeated measures were applied.
Results Fifty patients (26 females) with a median age of 47 years (18–76) were included. Before treatment, all QoL domains were significantly impaired compared with an age- and gender-adjusted reference population (P < 0.05). No significant QoL-differences were found after POEM, except for fatigue and nausea/vomiting. Clinically relevant QoL improvement was observed in ≥ 50 % of the patients in all QoL domains, except for physical and role functioning. QoL was significantly associated with ES (P < 0.05) but not with objective results.
Conclusions Achalasia is associated with severe QoL impairment. Following POEM, a significant and clinically relevant QoL improvement is observed. QoL is associated with ES, but not with objective results after POEM. |
| first_indexed | 2024-04-12T00:47:25Z |
| format | Article |
| id | doaj.art-b146ccf4002e4a778216f4a1dffde69d |
| institution | Directory Open Access Journal |
| issn | 2364-3722 2196-9736 |
| language | English |
| last_indexed | 2024-04-12T00:47:25Z |
| publishDate | 2022-12-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Endoscopy International Open |
| spelling | doaj.art-b146ccf4002e4a778216f4a1dffde69d2022-12-22T03:54:51ZengGeorg Thieme Verlag KGEndoscopy International Open2364-37222196-97362022-12-011012E1570E157610.1055/a-1968-7682Quality of life in patients with achalasia: Associations with Eckardt score and objective treatment outcomes after peroral endoscopic myotomyHelge Evensen0Marianne Jensen Hjermstad1Milada Cvancarova2Vendel Kristensen3Lene Larssen4Jorunn Skattum5Truls Hauge6Olav Sandstad7Asle W. Medhus8Department of Gastroenterology, Oslo University Hospital, NorwayRegional Advisory Unit for Palliative Care, Dept. of Oncology, Oslo University Hospital, NorwayDepartment of Gastroenterology, Oslo University Hospital, NorwayDepartment of Gastroenterology, Oslo University Hospital, NorwayDepartment of Gastroenterology, Oslo University Hospital, NorwayDepartment of Abdominal Surgery, Innlandet Hospital Trust, Hamar, NorwayDepartment of Gastroenterology, Oslo University Hospital, NorwayDepartment of Gastroenterology, Oslo University Hospital, NorwayDepartment of Gastroenterology, Oslo University Hospital, NorwayBackground and study aims Knowledge on self-reported quality of life (QoL) in achalasia and QoL improvements after peroral endoscopic myotomy (POEM) is limited. Furthermore, the clinical role of QoL in achalasia follow-up has not been evaluated. The present study aimed to examine QoL in achalasia patients before and after POEM and assess associations between QoL, Eckardt score (ES) and objective results. Patients and methods This was a single-center prospective study of treatment-naïve achalasia patients with 12-month follow-up after POEM including manometry, upper endoscopy, 24-hour pH registration, and timed barium esophagogram. QoL data were registered using European Organisation for Research and Treatment of Cancer core questionnaire (QLQ-C30) and esophageal module (QLQ-OES18). Comparison with a reference population was performed to assess impact of achalasia on QoL and effect of therapy. Mixed models for repeated measures were applied. Results Fifty patients (26 females) with a median age of 47 years (18–76) were included. Before treatment, all QoL domains were significantly impaired compared with an age- and gender-adjusted reference population (P < 0.05). No significant QoL-differences were found after POEM, except for fatigue and nausea/vomiting. Clinically relevant QoL improvement was observed in ≥ 50 % of the patients in all QoL domains, except for physical and role functioning. QoL was significantly associated with ES (P < 0.05) but not with objective results. Conclusions Achalasia is associated with severe QoL impairment. Following POEM, a significant and clinically relevant QoL improvement is observed. QoL is associated with ES, but not with objective results after POEM.http://www.thieme-connect.de/DOI/DOI?10.1055/a-1968-7682 |
| spellingShingle | Helge Evensen Marianne Jensen Hjermstad Milada Cvancarova Vendel Kristensen Lene Larssen Jorunn Skattum Truls Hauge Olav Sandstad Asle W. Medhus Quality of life in patients with achalasia: Associations with Eckardt score and objective treatment outcomes after peroral endoscopic myotomy Endoscopy International Open |
| title | Quality of life in patients with achalasia: Associations with Eckardt score and objective treatment outcomes after peroral endoscopic myotomy |
| title_full | Quality of life in patients with achalasia: Associations with Eckardt score and objective treatment outcomes after peroral endoscopic myotomy |
| title_fullStr | Quality of life in patients with achalasia: Associations with Eckardt score and objective treatment outcomes after peroral endoscopic myotomy |
| title_full_unstemmed | Quality of life in patients with achalasia: Associations with Eckardt score and objective treatment outcomes after peroral endoscopic myotomy |
| title_short | Quality of life in patients with achalasia: Associations with Eckardt score and objective treatment outcomes after peroral endoscopic myotomy |
| title_sort | quality of life in patients with achalasia associations with eckardt score and objective treatment outcomes after peroral endoscopic myotomy |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1968-7682 |
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