Senataxin Ortholog Sen1 Limits DNA:RNA Hybrid Accumulation at DNA Double-Strand Breaks to Control End Resection and Repair Fidelity

Senataxin Ortholog Sen1 Limits DNA:RNA Hybrid Accumulation at DNA Double-Strand Breaks to Control End Resection and Repair Fidelity

Summary: An important but still enigmatic function of DNA:RNA hybrids is their role in DNA double-strand break (DSB) repair. Here, we show that Sen1, the budding yeast ortholog of the human helicase Senataxin, is recruited at an HO endonuclease-induced DSB and limits the local accumulation of DNA:RN...

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Bibliographic Details
Main Authors: Chetan C. Rawal, Luca Zardoni, Matteo Di Terlizzi, Elena Galati, Alessandra Brambati, Federico Lazzaro, Giordano Liberi, Achille Pellicioli
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
DSB resection
DSB repair
Sen1/Senataxin
DNA:RNA hybrid
Mre11
Dna2
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720305520

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