Early prediction of spontaneous Patent Ductus Arteriosus (PDA) closure and PDA-associated outcomes: a prospective cohort investigation
Abstract Background Patent ductus arteriosus (PDA), the most commonly diagnosed cardiovascular condition in preterm infants, is associated with increased mortality and harmful long-term outcomes (chronic lung disease, neurodevelopmental delay). Although pharmacologic and/or interventional treatments...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-09-01
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| Series: | BMC Pediatrics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12887-019-1708-z |
| _version_ | 1818359299202613248 |
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| author | Jonathan L. Slaughter Clifford L. Cua Jennifer L. Notestine Brian K. Rivera Laura Marzec Erinn M. Hade Nathalie L. Maitre Mark A. Klebanoff Megan Ilgenfritz Vi T. Le Dennis J. Lewandowski Carl H. Backes |
| author_facet | Jonathan L. Slaughter Clifford L. Cua Jennifer L. Notestine Brian K. Rivera Laura Marzec Erinn M. Hade Nathalie L. Maitre Mark A. Klebanoff Megan Ilgenfritz Vi T. Le Dennis J. Lewandowski Carl H. Backes |
| author_sort | Jonathan L. Slaughter |
| collection | DOAJ |
| description | Abstract Background Patent ductus arteriosus (PDA), the most commonly diagnosed cardiovascular condition in preterm infants, is associated with increased mortality and harmful long-term outcomes (chronic lung disease, neurodevelopmental delay). Although pharmacologic and/or interventional treatments to close PDA likely benefit some infants, widespread routine treatment of all preterm infants with PDA may not improve outcomes. Most PDAs close spontaneously by 44-weeks postmenstrual age; treatment is increasingly controversial, varying markedly between institutions and providers. Because treatment detriments may outweigh benefits, especially in infants destined for early, spontaneous PDA closure, the relevant unanswered clinical question is not whether to treat all preterm infants with PDA, but whom to treat (and when). Clinicians cannot currently predict in the first month which infants are at highest risk for persistent PDA, nor which combination of clinical risk factors, echocardiographic measurements, and biomarkers best predict PDA-associated harm. Methods Prospective cohort of untreated infants with PDA (n=450) will be used to predict spontaneous ductal closure timing. Clinical measures, serum (brain natriuretic peptide, N-terminal pro-brain natriuretic peptide) and urine (neutrophil gelatinase-associated lipocalin, heart-type fatty acid-binding protein) biomarkers, and echocardiographic variables collected during each of first 4 postnatal weeks will be analyzed to identify those associated with long-term impairment. Myocardial deformation imaging and tissue Doppler imaging, innovative echocardiographic techniques, will facilitate quantitative evaluation of myocardial performance. Aim1 will estimate probability of spontaneous PDA closure and predict timing of ductal closure using echocardiographic, biomarker, and clinical predictors. Aim2 will specify which echocardiographic predictors and biomarkers are associated with mortality and respiratory illness severity at 36-weeks postmenstrual age. Aim3 will identify which echocardiographic predictors and biomarkers are associated with 22 to 26-month neurodevelopmental delay. Models will be validated in a separate cohort of infants (n=225) enrolled subsequent to primary study cohort. Discussion The current study will make significant contributions to scientific knowledge and effective PDA management. Study results will reduce unnecessary and harmful overtreatment of infants with a high probability of early spontaneous PDA closure and facilitate development of outcomes-focused trials to examine effectiveness of PDA closure in “high-risk” infants most likely to receive benefit. Trial registration ClinicalTrials.gov NCT03782610. Registered 20 December 2018. |
| first_indexed | 2024-12-13T20:42:41Z |
| format | Article |
| id | doaj.art-b149b69017404daf8099b892b452e40c |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-12-13T20:42:41Z |
| publishDate | 2019-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-b149b69017404daf8099b892b452e40c2022-12-21T23:32:07ZengBMCBMC Pediatrics1471-24312019-09-0119111710.1186/s12887-019-1708-zEarly prediction of spontaneous Patent Ductus Arteriosus (PDA) closure and PDA-associated outcomes: a prospective cohort investigationJonathan L. Slaughter0Clifford L. Cua1Jennifer L. Notestine2Brian K. Rivera3Laura Marzec4Erinn M. Hade5Nathalie L. Maitre6Mark A. Klebanoff7Megan Ilgenfritz8Vi T. Le9Dennis J. Lewandowski10Carl H. Backes11Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children’s HospitalDepartment of Pediatrics, Nationwide Children’s HospitalCenter for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children’s HospitalCenter for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children’s HospitalCenter for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children’s HospitalDepartment of Biomedical Informatics, Center for Biostatistics, The Ohio State UniversityCenter for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children’s HospitalCenter for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children’s HospitalDepartment of Pediatrics, Nationwide Children’s HospitalCenter for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children’s HospitalCenter for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children’s HospitalCenter for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children’s HospitalAbstract Background Patent ductus arteriosus (PDA), the most commonly diagnosed cardiovascular condition in preterm infants, is associated with increased mortality and harmful long-term outcomes (chronic lung disease, neurodevelopmental delay). Although pharmacologic and/or interventional treatments to close PDA likely benefit some infants, widespread routine treatment of all preterm infants with PDA may not improve outcomes. Most PDAs close spontaneously by 44-weeks postmenstrual age; treatment is increasingly controversial, varying markedly between institutions and providers. Because treatment detriments may outweigh benefits, especially in infants destined for early, spontaneous PDA closure, the relevant unanswered clinical question is not whether to treat all preterm infants with PDA, but whom to treat (and when). Clinicians cannot currently predict in the first month which infants are at highest risk for persistent PDA, nor which combination of clinical risk factors, echocardiographic measurements, and biomarkers best predict PDA-associated harm. Methods Prospective cohort of untreated infants with PDA (n=450) will be used to predict spontaneous ductal closure timing. Clinical measures, serum (brain natriuretic peptide, N-terminal pro-brain natriuretic peptide) and urine (neutrophil gelatinase-associated lipocalin, heart-type fatty acid-binding protein) biomarkers, and echocardiographic variables collected during each of first 4 postnatal weeks will be analyzed to identify those associated with long-term impairment. Myocardial deformation imaging and tissue Doppler imaging, innovative echocardiographic techniques, will facilitate quantitative evaluation of myocardial performance. Aim1 will estimate probability of spontaneous PDA closure and predict timing of ductal closure using echocardiographic, biomarker, and clinical predictors. Aim2 will specify which echocardiographic predictors and biomarkers are associated with mortality and respiratory illness severity at 36-weeks postmenstrual age. Aim3 will identify which echocardiographic predictors and biomarkers are associated with 22 to 26-month neurodevelopmental delay. Models will be validated in a separate cohort of infants (n=225) enrolled subsequent to primary study cohort. Discussion The current study will make significant contributions to scientific knowledge and effective PDA management. Study results will reduce unnecessary and harmful overtreatment of infants with a high probability of early spontaneous PDA closure and facilitate development of outcomes-focused trials to examine effectiveness of PDA closure in “high-risk” infants most likely to receive benefit. Trial registration ClinicalTrials.gov NCT03782610. Registered 20 December 2018.http://link.springer.com/article/10.1186/s12887-019-1708-zpatent ductus arteriosuspreterm infantechocardiogramprospective cohortprediction modeling |
| spellingShingle | Jonathan L. Slaughter Clifford L. Cua Jennifer L. Notestine Brian K. Rivera Laura Marzec Erinn M. Hade Nathalie L. Maitre Mark A. Klebanoff Megan Ilgenfritz Vi T. Le Dennis J. Lewandowski Carl H. Backes Early prediction of spontaneous Patent Ductus Arteriosus (PDA) closure and PDA-associated outcomes: a prospective cohort investigation BMC Pediatrics patent ductus arteriosus preterm infant echocardiogram prospective cohort prediction modeling |
| title | Early prediction of spontaneous Patent Ductus Arteriosus (PDA) closure and PDA-associated outcomes: a prospective cohort investigation |
| title_full | Early prediction of spontaneous Patent Ductus Arteriosus (PDA) closure and PDA-associated outcomes: a prospective cohort investigation |
| title_fullStr | Early prediction of spontaneous Patent Ductus Arteriosus (PDA) closure and PDA-associated outcomes: a prospective cohort investigation |
| title_full_unstemmed | Early prediction of spontaneous Patent Ductus Arteriosus (PDA) closure and PDA-associated outcomes: a prospective cohort investigation |
| title_short | Early prediction of spontaneous Patent Ductus Arteriosus (PDA) closure and PDA-associated outcomes: a prospective cohort investigation |
| title_sort | early prediction of spontaneous patent ductus arteriosus pda closure and pda associated outcomes a prospective cohort investigation |
| topic | patent ductus arteriosus preterm infant echocardiogram prospective cohort prediction modeling |
| url | http://link.springer.com/article/10.1186/s12887-019-1708-z |
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