Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum

The skin offers an accessible and convenient site for the administration of medications. To this end, the field of transdermal drug delivery, aimed at developing safe and efficacious means of delivering medications across the skin, has in the past and continues to garner much time and investment wit...

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Main Authors: Ahlam Zaid Alkilani, Maelíosa T. C. McCrudden, Ryan F. Donnelly
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Pharmaceutics
Subjects:
Online Access:http://www.mdpi.com/1999-4923/7/4/438
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author Ahlam Zaid Alkilani
Maelíosa T. C. McCrudden
Ryan F. Donnelly
author_facet Ahlam Zaid Alkilani
Maelíosa T. C. McCrudden
Ryan F. Donnelly
author_sort Ahlam Zaid Alkilani
collection DOAJ
description The skin offers an accessible and convenient site for the administration of medications. To this end, the field of transdermal drug delivery, aimed at developing safe and efficacious means of delivering medications across the skin, has in the past and continues to garner much time and investment with the continuous advancement of new and innovative approaches. This review details the progress and current status of the transdermal drug delivery field and describes numerous pharmaceutical developments which have been employed to overcome limitations associated with skin delivery systems. Advantages and disadvantages of the various approaches are detailed, commercially marketed products are highlighted and particular attention is paid to the emerging field of microneedle technologies.
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spelling doaj.art-b149c7c132cb4d74b72a306c3644b26e2022-12-22T02:06:32ZengMDPI AGPharmaceutics1999-49232015-10-017443847010.3390/pharmaceutics7040438pharmaceutics7040438Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum CorneumAhlam Zaid Alkilani0Maelíosa T. C. McCrudden1Ryan F. Donnelly2School of Pharmacy, 97 Lisburn Road, Queens University Belfast, Belfast BT9 7BL, Northern Ireland, UKSchool of Pharmacy, 97 Lisburn Road, Queens University Belfast, Belfast BT9 7BL, Northern Ireland, UKSchool of Pharmacy, 97 Lisburn Road, Queens University Belfast, Belfast BT9 7BL, Northern Ireland, UKThe skin offers an accessible and convenient site for the administration of medications. To this end, the field of transdermal drug delivery, aimed at developing safe and efficacious means of delivering medications across the skin, has in the past and continues to garner much time and investment with the continuous advancement of new and innovative approaches. This review details the progress and current status of the transdermal drug delivery field and describes numerous pharmaceutical developments which have been employed to overcome limitations associated with skin delivery systems. Advantages and disadvantages of the various approaches are detailed, commercially marketed products are highlighted and particular attention is paid to the emerging field of microneedle technologies.http://www.mdpi.com/1999-4923/7/4/438transdermaldrug deliveryvelocity based deviceultrasoundthermal ablationmechanical and electrical approachesmicroneedle
spellingShingle Ahlam Zaid Alkilani
Maelíosa T. C. McCrudden
Ryan F. Donnelly
Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum
Pharmaceutics
transdermal
drug delivery
velocity based device
ultrasound
thermal ablation
mechanical and electrical approaches
microneedle
title Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum
title_full Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum
title_fullStr Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum
title_full_unstemmed Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum
title_short Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum
title_sort transdermal drug delivery innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum
topic transdermal
drug delivery
velocity based device
ultrasound
thermal ablation
mechanical and electrical approaches
microneedle
url http://www.mdpi.com/1999-4923/7/4/438
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