Novel subtypes of NPM1-mutated AML with distinct outcome
Acute myeloid leukemia (AML) is heterogeneous with one common subtype recognized by the presence of recurrent mutation of nucleophosmin-1 (NPM1). Emerging evidence indicates that within NPM1 mutated AML there is variation in outcome which challenges how best to characterize and treat the individual...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-07-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2021.1924600 |
| _version_ | 1827809361976623104 |
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| author | Arvind Singh Mer Mark D. Minden Benjamin Haibe-Kains Aaron D. Schimmer |
| author_facet | Arvind Singh Mer Mark D. Minden Benjamin Haibe-Kains Aaron D. Schimmer |
| author_sort | Arvind Singh Mer |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML) is heterogeneous with one common subtype recognized by the presence of recurrent mutation of nucleophosmin-1 (NPM1). Emerging evidence indicates that within NPM1 mutated AML there is variation in outcome which challenges how best to characterize and treat the individual patient. Our recent findings show that there are two distinct (primitive and committed) subtypes within NPM1 mutated AML patients. These subtypes exhibit specific molecular characteristics, disease differentiation states, patient survival, and differential drug responses. |
| first_indexed | 2024-03-11T22:40:08Z |
| format | Article |
| id | doaj.art-b14aa391fd0d47b1a9701abe91233208 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:08Z |
| publishDate | 2021-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-b14aa391fd0d47b1a9701abe912332082023-09-22T09:19:43ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562021-07-018410.1080/23723556.2021.19246001924600Novel subtypes of NPM1-mutated AML with distinct outcomeArvind Singh Mer0Mark D. Minden1Benjamin Haibe-Kains2Aaron D. Schimmer3University Health NetworkUniversity Health NetworkUniversity Health NetworkUniversity Health NetworkAcute myeloid leukemia (AML) is heterogeneous with one common subtype recognized by the presence of recurrent mutation of nucleophosmin-1 (NPM1). Emerging evidence indicates that within NPM1 mutated AML there is variation in outcome which challenges how best to characterize and treat the individual patient. Our recent findings show that there are two distinct (primitive and committed) subtypes within NPM1 mutated AML patients. These subtypes exhibit specific molecular characteristics, disease differentiation states, patient survival, and differential drug responses.http://dx.doi.org/10.1080/23723556.2021.1924600acute myeloid leukemiabiomarkerssubtypemachine learningsystems biology |
| spellingShingle | Arvind Singh Mer Mark D. Minden Benjamin Haibe-Kains Aaron D. Schimmer Novel subtypes of NPM1-mutated AML with distinct outcome Molecular & Cellular Oncology acute myeloid leukemia biomarkers subtype machine learning systems biology |
| title | Novel subtypes of NPM1-mutated AML with distinct outcome |
| title_full | Novel subtypes of NPM1-mutated AML with distinct outcome |
| title_fullStr | Novel subtypes of NPM1-mutated AML with distinct outcome |
| title_full_unstemmed | Novel subtypes of NPM1-mutated AML with distinct outcome |
| title_short | Novel subtypes of NPM1-mutated AML with distinct outcome |
| title_sort | novel subtypes of npm1 mutated aml with distinct outcome |
| topic | acute myeloid leukemia biomarkers subtype machine learning systems biology |
| url | http://dx.doi.org/10.1080/23723556.2021.1924600 |
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